Tnfsf8 MGI Mouse Gene Detail - MGI:88328 - tumor necrosis factor (ligand) superfamily, member 8

Tnfsf8 Gene Detail

Symbol

Tnfsf8
Name

tumor necrosis factor (ligand) superfamily, member 8
Synonyms

CD153, Cd30L, CD30LG

Feature Type

protein coding gene
IDs

MGI:88328
NCBI Gene: 21949

Sequence Map

Chr4:63831308-63861347 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

30040 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 34.06 cM
Mapping Data

7 experiments

Human Ortholog

TNFSF8, TNF superfamily member 8

Vertebrate Orthologs

8

Human Ortholog

TNFSF8, TNF superfamily member 8
Orthology source: HomoloGene, HGNC
Synonyms

CD153, CD30L, CD30LG, TNLG3A
Links

HGNC:11938

NCBI Gene ID: 944

neXtProt AC: NX_P32971

UniProt: P32971
Chr Location

9q32-q33.1; chr9:114893343-114930595 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 950
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 macaque, rhesus
HCOP

human homology predictions: TNFSF8
Protein SuperFamily

tumour necrosis factor family protein, CD30 ligand type
Gene Tree

Tnfsf8

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available

Homozygous null mice diplay decreased susceptibility to graft versus host disease.

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All GO Annotations

11
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

24
Tissues

15
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Tnfsf8 interacts with 317 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

22
RefSeq

4
UniProt

3
CCDS

CCDS18264.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000000301	VEGA Gene Model \| MGI Sequence Detail	30040	C57BL/6J	± kb
transcript	OTTMUST00000000772	VEGA \| MGI Sequence Detail	3807	Not Applicable
polypeptide	OTTMUSP00000000340	VEGA \| MGI Sequence Detail	239	Not Applicable

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SNPs within 2kb

222 from dbSNP Build 142

PCR

1
RFLP

4

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UniProt

3 Sequences
Protein Ontology

PR:000001404 tumor necrosis factor ligand superfamily member 8

(term hierarchy)
InterPro Domains

IPR021184 Tumour necrosis factor, conserved site

IPR006052 Tumour necrosis factor domain

IPR021185 Tumour necrosis factor family protein, CD30 ligand type

IPR008983 Tumour necrosis factor-like domain

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All nucleic 14

cDNA 12

Primer pair 1

Other 1

Microarray probesets 5

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MGD-MRK-1847

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 7
Earliest

J:12921 Smith CA, et al., CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell. 1993 Jul 2;73(7):1349-60
Latest

J:200593 Guo Y, et al., CD30 Is Required for Activation of a Unique Subset of Interleukin-17A-Producing gammadelta T Cells in Innate Immunity against Mycobacterium bovis Bacillus Calmette-Guerin Infection. Infect Immun. 2013 Oct;81(10):3923-34

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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