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Tnfsf8 Gene Detail
Summary
  • Symbol
    Tnfsf8
  • Name
    tumor necrosis factor (ligand) superfamily, member 8
  • Synonyms
    CD153, Cd30L, CD30LG
  • Feature Type
    protein coding gene
  • IDs
    MGI:88328
    NCBI Gene: 21949
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:63831308-63861347 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 34.06 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88328
 protein coding gene Chr4:63831202-63861508 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028374
 protein coding gene Chr4:62862217-62896110 (-)
A/J MGP_AJ_G0028335
 protein coding gene Chr4:60601653-60633747 (-)
AKR/J MGP_AKRJ_G0028284
 protein coding gene Chr4:62258774-62288591 (-)
BALB/cJ MGP_BALBcJ_G0028355
 protein coding gene Chr4:60788561-60818380 (-)
C3H/HeJ MGP_C3HHeJ_G0028070
 protein coding gene Chr4:62770619-62800402 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028795
 protein coding gene Chr4:65001739-65034197 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026098
 protein coding gene Chr4:57941134-57970763 (-)
CAST/EiJ MGP_CASTEiJ_G0027509
 protein coding gene Chr4:60774315-60804848 (-)
CBA/J MGP_CBAJ_G0028039
 protein coding gene Chr4:67295650-67329242 (-)
DBA/2J MGP_DBA2J_G0028188
 protein coding gene Chr4:60443338-60473955 (-)
FVB/NJ MGP_FVBNJ_G0028154
 protein coding gene Chr4:59728383-59757162 (-)
LP/J MGP_LPJ_G0028287
 protein coding gene Chr4:63156771-63187030 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028183
 protein coding gene Chr4:70376199-70406602 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028831
 protein coding gene Chr4:62365061-62399057 (-)
PWK/PhJ MGP_PWKPhJ_G0027238
 protein coding gene Chr4:59006093-59038303 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027064
 protein coding gene Chr4:59834247-59870300 (-)
WSB/EiJ MGP_WSBEiJ_G0027588
 protein coding gene Chr4:62400261-62431713 (-)



Homology
more
  • Human Ortholog
    TNFSF8, TNF superfamily member 8
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TNFSF8, TNF superfamily member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD153, CD30L, CD30LG, TNLG3A
  • Links
    NCBI Gene ID: 944
    neXtProt AC: NX_P32971
    UniProt: P32971

  • Chr Location
    9q32-q33.1; chr9:114893343-114930595 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice diplay decreased susceptibility to graft versus host disease.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    655
  • Tissues
    15
  • cDNA Data
    13
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028362 Ensembl Gene Model | MGI Sequence Detail 30040 C57BL/6J ±  kb
transcript ENSMUST00000030047 Ensembl | MGI Sequence Detail 3807 Not Applicable  
polypeptide ENSMUSP00000030047 Ensembl | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001404 tumor necrosis factor ligand superfamily member 8
    (term hierarchy)
  • InterPro Domains
    IPR021184 Tumour necrosis factor, conserved site
    IPR006052 Tumour necrosis factor domain
    IPR021185 Tumour necrosis factor family protein, CD30 ligand type
    IPR008983 Tumour necrosis factor-like domain superfamily
Molecular
Reagents
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  • All nucleic 15
    cDNA 13
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-1847
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:12921 Smith CA, et al., CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell. 1993 Jul 2;73(7):1349-60
  • Latest
    J:290693 Duan J, et al., CD30 ligand deficiency accelerates glioma progression by promoting the formation of tumor immune microenvironment. Int Immunopharmacol. 2019 Jun;71:350-360
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
01/05/2021
MGI 6.16 		The Jackson Laboratory