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Tnfsf8 Gene Detail
Summary
  • Symbol
    Tnfsf8
  • Name
    tumor necrosis factor (ligand) superfamily, member 8
  • Synonyms
    CD153, Cd30L, CD30LG
  • Feature Type
    protein coding gene
  • IDs
    MGI:88328
    NCBI Gene: 21949
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:63749545-63779584 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 34.06 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    950 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88328
 protein coding gene Chr4:63749439-63779745 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028374
 protein coding gene Chr4:62862217-62896110 (-)
A/J MGP_AJ_G0028335
 protein coding gene Chr4:60601653-60633747 (-)
AKR/J MGP_AKRJ_G0028284
 protein coding gene Chr4:62258774-62288591 (-)
BALB/cJ MGP_BALBcJ_G0028355
 protein coding gene Chr4:60788561-60818380 (-)
C3H/HeJ MGP_C3HHeJ_G0028070
 protein coding gene Chr4:62770619-62800402 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028795
 protein coding gene Chr4:65001739-65034197 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026098
 protein coding gene Chr4:57941134-57970763 (-)
CAST/EiJ MGP_CASTEiJ_G0027509
 protein coding gene Chr4:60774315-60804848 (-)
CBA/J MGP_CBAJ_G0028039
 protein coding gene Chr4:67295650-67329242 (-)
DBA/2J MGP_DBA2J_G0028188
 protein coding gene Chr4:60443338-60473955 (-)
FVB/NJ MGP_FVBNJ_G0028154
 protein coding gene Chr4:59728383-59757162 (-)
LP/J MGP_LPJ_G0028287
 protein coding gene Chr4:63156771-63187030 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028183
 protein coding gene Chr4:70376199-70406602 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028831
 protein coding gene Chr4:62365061-62399057 (-)
PWK/PhJ MGP_PWKPhJ_G0027238
 protein coding gene Chr4:59006093-59038303 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027064
 protein coding gene Chr4:59834247-59870300 (-)
WSB/EiJ MGP_WSBEiJ_G0027588
 protein coding gene Chr4:62400261-62431713 (-)



Homology
more
  • Human Ortholog
    TNFSF8, TNF superfamily member 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFSF8, TNF superfamily member 8
  • Synonyms
    CD153, CD30L, CD30LG, TNLG3A
  • Links
    NCBI Gene ID: 944
    UniProt: P32971

  • Chr Location
    9q32-q33.1; chr9:114893343-114930595 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice diplay decreased susceptibility to graft versus host disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028362 Ensembl Gene Model | MGI Sequence Detail 30040 C57BL/6J ±  kb
    transcript ENSMUST00000030047 Ensembl | MGI Sequence Detail 3807 Not Applicable  
    polypeptide ENSMUSP00000030047 Ensembl | MGI Sequence Detail 239 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000001404 tumor necrosis factor ligand superfamily member 8
      (term hierarchy)
    • InterPro Domains
      IPR053104 Tumor Necrosis Factor Ligand Superfamily Member 8
      IPR021184 Tumour necrosis factor, conserved site
      IPR006052 Tumour necrosis factor domain
      IPR021185 Tumour necrosis factor family protein, CD30 ligand type
      IPR008983 Tumour necrosis factor-like domain superfamily
    • GlyGen
      P32972 6 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1847
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:12921 Smith CA, et al., CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell. 1993 Jul 2;73(7):1349-60
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory