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Cd27 Gene Detail
Summary
  • Symbol
    Cd27
  • Name
    CD27 antigen
  • Synonyms
    Cd27, S152, Tnfrsf7, Tp55
  • Feature Type
    protein coding gene
  • IDs
    MGI:88326
    NCBI Gene: 21940
  • Gene Overview
    MyGene.info: CD27
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125232622-125237010 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.32 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88326
protein coding gene Chr6:125232620-125237027 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031293
protein coding gene Chr6:128573572-128577949 (-)
A/J MGP_AJ_G0031263
protein coding gene Chr6:123718567-123722974 (-)
AKR/J MGP_AKRJ_G0031191
protein coding gene Chr6:127098586-127102941 (-)
BALB/cJ MGP_BALBcJ_G0031271
protein coding gene Chr6:123315947-123320299 (-)
C3H/HeJ MGP_C3HHeJ_G0030994
protein coding gene Chr6:127167498-127171849 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031727
protein coding gene Chr6:131962700-131967079 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028876
protein coding gene Chr6:120928764-120933203 (-)
CAST/EiJ MGP_CASTEiJ_G0030375
protein coding gene Chr6:127374726-127380902 (-)
CBA/J MGP_CBAJ_G0030955
protein coding gene Chr6:137009190-137013544 (-)
DBA/2J MGP_DBA2J_G0031111
protein coding gene Chr6:122650455-122654817 (-)
FVB/NJ MGP_FVBNJ_G0031061
protein coding gene Chr6:121563781-121568136 (-)
LP/J MGP_LPJ_G0031191
protein coding gene Chr6:128731653-128736003 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031099
protein coding gene Chr6:141040636-141044996 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031762
protein coding gene Chr6:127000349-127004727 (-)
PWK/PhJ MGP_PWKPhJ_G0030090
protein coding gene Chr6:120894340-120898776 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029919
protein coding gene Chr6:125074932-125079808 (-)
WSB/EiJ MGP_WSBEiJ_G0030460
protein coding gene Chr6:127368414-127372804 (-)



Homology
more
  • Human Ortholog
    CD27, CD27 molecule
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CD27, CD27 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    S152, S152. LPFS2, T14, TNFRSF7, Tp55
  • Links
    NCBI Gene ID: 939
    neXtProt AC: NX_P26842
    UniProt: P26842

  • Chr Location
    12p13.31; chr12:6444867-6451718 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CD27 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a normal phenotype. However, T-cell development immune responses are abnormal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030336 Ensembl Gene Model | MGI Sequence Detail 4389 C57BL/6J ±  kb
transcript ENSMUST00000032486 Ensembl | MGI Sequence Detail 1559 Not Applicable  
polypeptide ENSMUSP00000032486 Ensembl | MGI Sequence Detail 250 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    Genomic 8
    cDNA 20
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1844
References
more
  • Summaries
    All 95
    Developmental Gene Expression 2
    Gene Ontology 12
    Phenotypes 42
  • Earliest
    J:4937 Gravestein LA, et al., Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family. Eur J Immunol. 1993 Apr;23(4):943-50
  • Latest
    J:233774 Mathieu C, et al., IL-2 and IL-15 regulate CD8+ memory T-cell differentiation but are dispensable for protective recall responses. Eur J Immunol. 2015 Dec;45(12):3324-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory