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Cd27
Gene Detail
Symbol

Name
ID
Cd27
CD27 antigen
MGI:88326
Synonyms
Cd27, S152, Tnfrsf7, Tp55
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:125232622-125237010 bp, - strand
From VEGA annotation of GRCm38

  4389 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74386  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CD27
Protein SuperFamily: tumor necrosis factor receptor superfamily member, CD40 type
Gene Tree: Cd27

Human
homologs
CD27, CD27 molecule
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 939
neXtProt AC: NX_P26842

Human Synonyms: S152, S152. LPFS2, T14, TNFRSF7, Tp55

Human Chr (Location): 12p13; chr12:6444885-6451718 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CD27

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
 
Mice homozygous for disruptions in this gene have a normal phenotype. However, T-cell development immune responses are abnormal.
 
Interactions
Cd27 interacts with 92 markers (Mir19a, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process apoptotic process, B cell proliferation, ...
Component cell, cell surface, ...
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (57)    Tissues (47)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
RT-PCR 46
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(8) cDNA(19) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024478 (Evidence)
Ensembl Gene Model ENSMUSG00000030336 (Evidence)
Entrez Gene 21940 (Evidence)
UniGene 367714
DFCI TC1583799, TC1657266, TC1665077
DoTS DT.40158786, DT.483987, DT.87070722
NIA Mouse Gene Index U027865
Consensus CDS Project CCDS39638.1, CCDS39639.1, CCDS71839.1
International Mouse Phenotyping Consortium Status Cd27
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024478 VEGA Gene Model | MGI Sequence Detail 4389 C57BL/6J ±  kb
transcript OTTMUST00000060042 VEGA | MGI Sequence Detail 1559 Not Applicable 
polypeptide OTTMUSP00000029268 VEGA | MGI Sequence Detail 250 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(14) UniProt(4)
Polymorphisms
SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR022328 Tumour necrosis factor receptor 7
Protein Ontology PR:000001963 CD27 molecule
References
(Earliest) J:4937 Gravestein LA, et al., Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family. Eur J Immunol. 1993 Apr;23(4):943-50
(Latest) J:221039 Dhainaut M, et al., Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells. EMBO J. 2015 May 12;34(10):1336-48
All references(86)
Other
accession IDs
MGD-MRK-1844

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory