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Cd27
Gene Detail
 Symbol
Name
ID
Cd27
CD27 antigen
MGI:88326
Synonyms Cd27, S152, Tnfrsf7, Tp55
Feature Type protein coding gene
Genetic Map
Chromosome 6
59.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:125232622-125237010 bp, - strand
From VEGA annotation of GRCm38

  4389 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74386  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tumor necrosis factor receptor superfamily member, CD40 type
Gene Tree: Cd27

Human
homologs
Human Homolog CD27, CD27 molecule
NCBI Gene ID 939
neXtProt AC  NX_P26842
Human Synonyms  S152, S152. LPFS2, T14, TNFRSF7, Tp55
Human Chr (Location)  12p13; chr12:6444885-6451718 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD27
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
 
Mice homozygous for disruptions in this gene have a normal phenotype. However, T-cell development immune responses are abnormal.
 
Interactions
Cd27 interacts with 92 markers (Mir19a, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process apoptotic process, B cell proliferation, ...
Component cell, cell surface, ...
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (57)    Tissues (47)    Images (10)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 11
RT-PCR 46
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(8) cDNA(19) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024478 (Evidence)
Ensembl Gene ModelENSMUSG00000030336 (Evidence)
Entrez Gene21940 (Evidence)
UniGene367714
DFCITC1583799, TC1657266, TC1665077
DoTSDT.40158786, DT.483987, DT.87070722
NIA Mouse Gene IndexU027865
Consensus CDS ProjectCCDS39638.1, CCDS39639.1, CCDS71839.1
International Mouse Knockout Project StatusCd27
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024478 VEGA Gene Model | MGI Sequence Detail 4389 C57BL/6J ±  kb
transcript OTTMUST00000060042 VEGA | MGI Sequence Detail 1559 Not Applicable 
polypeptide OTTMUSP00000029268 VEGA | MGI Sequence Detail 250 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(18) UniProt(4)
Polymorphisms SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR022328 Tumour necrosis factor receptor 7
Protein Ontology PR:000001963 CD27 molecule
References (Earliest) J:4937 Gravestein LA, et al., Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family. Eur J Immunol. 1993 Apr;23(4):943-50
(Latest) J:205807 Kuka M, et al., CD70 is downregulated by interaction with CD27. J Immunol. 2013 Sep 1;191(5):2282-9
All references(86)
Other
accession IDs
MGD-MRK-1844

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory