Ms4a1
Gene Detail

Symbol Name ID

Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 MGI:88321

Synonyms

Cd20, Ly-44

Feature Type

protein coding gene

Genetic Map

Chromosome 19

8.19 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr19:11250603-11266151 bp, - strand From NCBI annotation of GRCm38   15549 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7259  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: B-cell surface antigen CD20
Gene Tree: Ms4a1

Human homologs

Human Homolog		MS4A1, membrane-spanning 4-domains, subfamily A, member 1
NCBI Gene ID		931
neXtProt AC		NX_P11836
Human Synonyms		B1, Bp35, CD20, CVID5, LEU-16, MS4A2, S7
Human Chr (Location)		11q12; chr11:60223282-60238225 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MS4A1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous inactivation of this locus affects B cell physiology but does not impair B cell development or overall immune function.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	B cell activation
Component	external side of plasma membrane, integral to membrane, ...
Function	epidermal growth factor receptor binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (101)    Tissues (73)    Images (14)
Theiler Stages: 1, 2, 3, 5, 19, 23, 28

Assay Type	Results
RNA in situ	41
RT-PCR	60

cDNA source data(94)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(96) cDNA(94) Primer pair(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000024673 (Evidence)
Entrez Gene	12482 (Evidence)
UniGene	4046
DFCI	TC1572040, TC1662039
DoTS	DT.101380995, DT.101724724, DT.110856595, DT.91327133, DT.94188090, DT.97363320
NIA Mouse Gene Index	U038824
Consensus CDS Project	CCDS37923.1
International Mouse Knockout Project Status	Ms4a1

Sequences

Length	Strain/Species
genomic	12482	NCBI Gene Model | MGI Sequence Detail	15549	C57BL/6J
transcript	NM_007641	RefSeq | MGI Sequence Detail	2057	C57BL/6
polypeptide	P19437	UniProt | EBI | MGI Sequence Detail	291	Not Applicable

All sequences(39) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(6) : SNPs(104 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007237	CD20-like
Protein Ontology	PR:000001289	membrane-spanning 4-domains subfamily A member 1

Graphical View of Protein Domain Structure

References

(Earliest) J:9496 Tedder TF, et al., Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19. J Immunol. 1988 Dec 15;141(12):4388-94
(Latest) J:193035 Horikawa M, et al., Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. J Immunol. 2013 Feb 1;190(3):1158-68
All references(51)

Other accession IDs

MGD-MRK-11986, MGD-MRK-1838, MGI:2147465