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Ms4a1
Gene Detail
Symbol

Name
ID
Member of
Ms4a1
membrane-spanning 4-domains, subfamily A, member 1
MGI:88321
Ms4ac cluster
Synonyms
Cd20, Ly-44
Feature Type
protein coding gene
Genetic Map
Chromosome 19
8.19 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr19:11249675-11266241 bp, - strand
From VEGA annotation of GRCm38

  16567 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7259  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: MS4A1
Protein SuperFamily: B-cell surface antigen CD20
Gene Tree: Ms4a1

Human
homologs
MS4A1, membrane-spanning 4-domains, subfamily A, member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 931
neXtProt AC: NX_P11836

Human Synonyms: B1, Bp35, CD20, CVID5, LEU-16, MS4A2, S7

Human Chr (Location): 11q12; chr11:60455809-60470752 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MS4A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous inactivation of this locus affects B cell physiology but does not impair B cell development or overall immune function.
 
Interactions
Ms4a1 interacts with 196 markers (Mir7b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process B cell activation
Component external side of plasma membrane, extracellular exosome, ...
Function epidermal growth factor receptor binding, MHC class II protein complex binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (97)    Tissues (71)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
RT-PCR 56
cDNA source data(95)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ms4a1    NEW 
Molecular
reagents
All nucleic(97) cDNA(95) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000047066 (Evidence)
Ensembl Gene Model ENSMUSG00000024673 (Evidence)
Entrez Gene 12482 (Evidence)
UniGene 4046
DFCI TC1572040, TC1662039
DoTS DT.101380995, DT.101724724, DT.110856595, DT.91327133, DT.94188090, DT.97363320
NIA Mouse Gene Index U038824
Consensus CDS Project CCDS37923.1
International Mouse Phenotyping Consortium Status Ms4a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047066 VEGA Gene Model | MGI Sequence Detail 16567 C57BL/6J ±  kb
transcript OTTMUST00000121853 VEGA | MGI Sequence Detail 3075 Not Applicable 
polypeptide OTTMUSP00000067018 VEGA | MGI Sequence Detail 291 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(6) : SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007237 CD20-like
Protein Ontology PR:000001289 membrane-spanning 4-domains subfamily A member 1
References
(Earliest) J:9496 Tedder TF, et al., Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19. J Immunol. 1988 Dec 15;141(12):4388-94
(Latest) J:220497 Klasener K, et al., B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk. Elife. 2014;3:e02069
All references(51)
Other
accession IDs
MGD-MRK-11986, MGD-MRK-1838, MGI:2147465

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory