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Cd19 Gene Detail
Summary
  • Symbol
    Cd19
  • Name
    CD19 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:88319
    NCBI Gene: 12478
  • Gene Overview
    MyGene.info: CD19
Location & Maps
more
  • Sequence Map
    Chr7:126408450-126414889 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6440 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.01 cM, cytoband F3-F4
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CD19, CD19 molecule
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CD19, CD19 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B4, CVID3
  • Links
    NCBI Gene ID: 930
    neXtProt AC: NX_P15391

  • Chr Location
    16p11.2; chr16:28931916-28939347 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human CD19 associations

Human Disease Mouse Models
       Immunodeficiency, Common Variable, 2; CVID2   OMIM: 240500
Immunodeficiency, Common Variable, 3; CVID3   OMIM: 613493
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 3 alleles in 6 genetic backgrounds
    214 phenotypes from multigenic genotypes
    5 images
    391 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal B lymphocyte development, activation and differentiation, altered mast cell activation in a model for acute septic peritonitis, inhibition of bleomycin-induced fibrosis and autoantibody production, and increased susceptibility to EAE.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058214 VEGA Gene Model | MGI Sequence Detail 6440 C57BL/6J ±  kb
transcript OTTMUST00000142955 VEGA | MGI Sequence Detail 2452 Not Applicable  
polypeptide OTTMUSP00000074547 VEGA | MGI Sequence Detail 547 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    49 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
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  • All nucleic 51
    Genomic 6
    cDNA 42
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1833, MGI:2142241
References
more
  • Summaries
    All 451
    Developmental Gene Expression 7
    Diseases 3
    Gene Ontology 18
    Phenotypes 391
  • Earliest
    J:7105 Nadler LM, et al., B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. J Immunol. 1983 Jul;131(1):244-50
  • Latest
    J:235578 Kong S, et al., Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10394-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory