Cd19
Gene Detail

Symbol Name ID

Cd19 CD19 antigen MGI:88319

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.01 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:126408450-126414870 bp, - strand From Ensembl annotation of GRCm38   6421 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1341  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: CD19
Gene Tree: Cd19

Human homologs

Human Homolog		CD19, CD19 molecule
NCBI Gene ID		930
neXtProt AC		NX_P15391
Human Synonyms		B4, CVID3
Human Chr (Location)		16p11.2; chr16:28943260-28950668 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CD19

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit abnormal B lymphocyte development, activation and differentiation, altered mast cell activation in a model for acute septic peritonitis, inhibition of bleomycin-induced fibrosis and autoantibody production, and increased susceptibility to EAE.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	B cell receptor signaling pathway
Component	external side of plasma membrane, integral to membrane, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (9)    Tissues (2)    Images (1)
Theiler Stages: 23, 28

Assay Type	Results
Immunohistochemistry	1
RT-PCR	8

cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(51) Genomic(6) cDNA(42) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030724 (Evidence)
Entrez Gene	12478 (Evidence)
UniGene	4360
DFCI	TC1582696, TC1657221
DoTS	DT.101710289, DT.490402
NIA Mouse Gene Index	U029242
Consensus CDS Project	CCDS21828.1
International Mouse Knockout Project Status	Cd19

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030724	Ensembl Gene Model | MGI Sequence Detail	6421	C57BL/6J
transcript	ENSMUST00000032968	Ensembl | MGI Sequence Detail	2434	Not Applicable
polypeptide	ENSMUSP00000032968	Ensembl | MGI Sequence Detail	547	Not Applicable

All sequences(28) RefSeq(2) UniProt(4)

Polymorphisms

PCR(1) : SNPs(42 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
Protein Ontology	PR:000001002	CD19 molecule

References

(Earliest) J:7105 Nadler LM, et al., B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. J Immunol. 1983 Jul;131(1):244-50
(Latest) J:193035 Horikawa M, et al., Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. J Immunol. 2013 Feb 1;190(3):1158-68
All references(343)

Other accession IDs

MGD-MRK-1833, MGI:2142241