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Cd19
Gene Detail
Symbol

Name
ID
Cd19
CD19 antigen
MGI:88319
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.01 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:126408450-126414870 bp, - strand
From Ensembl annotation of GRCm38

  6421 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1341  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CD19
Protein SuperFamily: CD19
Gene Tree: Cd19

Human
homologs
CD19, CD19 molecule
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 930
neXtProt AC: NX_P15391

Human Synonyms: B4, CVID3

Human Chr (Location): 16p11.2; chr16:28931916-28939347 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CD19

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit abnormal B lymphocyte development, activation and differentiation, altered mast cell activation in a model for acute septic peritonitis, inhibition of bleomycin-induced fibrosis and autoantibody production, and increased susceptibility to EAE.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Cd19 interacts with 132 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (9)    Tissues (2)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RT-PCR 8
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) Genomic(6) cDNA(42) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000030724 (Evidence)
Entrez Gene 12478 (Evidence)
UniGene 4360
DFCI TC1582696, TC1657221
DoTS DT.101710289, DT.490402
NIA Mouse Gene Index U029242
Consensus CDS Project CCDS21828.1
International Mouse Phenotyping Consortium Status Cd19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030724 Ensembl Gene Model | MGI Sequence Detail 6421 C57BL/6J ±  kb
transcript ENSMUST00000032968 Ensembl | MGI Sequence Detail 2434 Not Applicable 
polypeptide ENSMUSP00000032968 Ensembl | MGI Sequence Detail 547 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000001002 CD19 molecule
References
(Earliest) J:7105 Nadler LM, et al., B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. J Immunol. 1983 Jul;131(1):244-50
(Latest) J:223138 Thompson BJ, et al., DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3. J Exp Med. 2015 Jun 1;212(6):953-70
All references(417)
Other
accession IDs
MGD-MRK-1833, MGI:2142241

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory