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Cd19 Gene Detail
Summary
  • Symbol
    Cd19
  • Name
    CD19 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:88319
    NCBI Gene: 12478
  • Gene Overview
    MyGene.info: CD19
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126408450-126414889 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.01 cM, cytoband F3-F4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    49 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88319
protein coding gene Chr7:126408448-126415143 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032978
protein coding gene Chr7:130676601-130683005 (-)
A/J MGP_AJ_G0032961
protein coding gene Chr7:127228109-127234513 (-)
AKR/J MGP_AKRJ_G0032893
protein coding gene Chr7:130443667-130450106 (-)
BALB/cJ MGP_BALBcJ_G0032966
protein coding gene Chr7:126883905-126890344 (-)
C3H/HeJ MGP_C3HHeJ_G0032676
protein coding gene Chr7:130370564-130377003 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033472
protein coding gene Chr7:135768310-135774749 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030444
protein coding gene Chr7:128424059-128430482 (-)
CAST/EiJ MGP_CASTEiJ_G0032004
protein coding gene Chr7:122156705-122163118 (-)
CBA/J MGP_CBAJ_G0032649
protein coding gene Chr7:140342935-140349374 (-)
DBA/2J MGP_DBA2J_G0032801
protein coding gene Chr7:125201241-125207680 (-)
FVB/NJ MGP_FVBNJ_G0032754
protein coding gene Chr7:125049387-125055791 (-)
LP/J MGP_LPJ_G0032895
protein coding gene Chr7:132146677-132153081 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032786
protein coding gene Chr7:141532909-141539319 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033492
protein coding gene Chr7:129464087-129470491 (-)
PWK/PhJ MGP_PWKPhJ_G0031712
protein coding gene Chr7:118186754-118193193 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031558
protein coding gene Chr7:116280609-116287010 (-)
WSB/EiJ MGP_WSBEiJ_G0032117
protein coding gene Chr7:130424679-130431083 (-)



Homology
more
  • Human Ortholog
    CD19, CD19 molecule
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CD19, CD19 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B4, CVID3
  • Links
    NCBI Gene ID: 930
    neXtProt AC: NX_P15391
    UniProt: P15391

  • Chr Location
    16p11.2; chr16:28931735-28939347 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CD19 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 3 alleles in 6 genetic backgrounds
    226 phenotypes from multigenic genotypes
    8 images
    459 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal B lymphocyte development, activation and differentiation, altered mast cell activation in a model for acute septic peritonitis, inhibition of bleomycin-induced fibrosis and autoantibody production, and increased susceptibility to EAE.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030724 Ensembl Gene Model | MGI Sequence Detail 6440 C57BL/6J ±  kb
    transcript ENSMUST00000206325 Ensembl | MGI Sequence Detail 2452 Not Applicable  
    polypeptide ENSMUSP00000145803 Ensembl | MGI Sequence Detail 547 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 6
      cDNA 43
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1833, MGI:2142241
    References
    more
    • Summaries
      All 537
      Developmental Gene Expression 8
      Diseases 6
      Gene Ontology 17
      Phenotypes 459
    • Earliest
      J:7105 Nadler LM, et al., B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. J Immunol. 1983 Jul;131(1):244-50
    • Latest
      J:264362 Yu J, et al., Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis. Am J Pathol. 2018 Jun;188(6):1430-1446

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory