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Cd19
Gene Detail
Symbol

Name
ID
Cd19
CD19 antigen
MGI:88319
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.01 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:126408450-126414870 bp, - strand
From Ensembl annotation of GRCm38

  6421 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1341  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: CD19
Gene Tree: Cd19

Human
homologs
Human Homolog CD19, CD19 molecule
NCBI Gene ID 930
neXtProt AC  NX_P15391
Human Synonyms  B4, CVID3
Human Chr (Location)  16p11.2; chr16:28931761-28939347 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CD19
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal B lymphocyte development, activation and differentiation, altered mast cell activation in a model for acute septic peritonitis, inhibition of bleomycin-induced fibrosis and autoantibody production, and increased susceptibility to EAE.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Cd19 interacts with 132 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (9)    Tissues (2)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RT-PCR 8
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) Genomic(6) cDNA(42) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030724 (Evidence)
Entrez Gene12478 (Evidence)
UniGene4360
DFCITC1582696, TC1657221
DoTSDT.101710289, DT.490402
NIA Mouse Gene IndexU029242
Consensus CDS ProjectCCDS21828.1
International Mouse Knockout Project StatusCd19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030724 Ensembl Gene Model | MGI Sequence Detail 6421 C57BL/6J ±  kb
transcript ENSMUST00000032968 Ensembl | MGI Sequence Detail 2434 Not Applicable 
polypeptide ENSMUSP00000032968 Ensembl | MGI Sequence Detail 547 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(8) UniProt(7)
Polymorphisms
PCR(1) : SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000001002 CD19 molecule
References
(Earliest) J:7105 Nadler LM, et al., B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. J Immunol. 1983 Jul;131(1):244-50
(Latest) J:214446 Kim TJ, et al., Innate lymphoid cells facilitate NK cell development through a lymphotoxin-mediated stromal microenvironment. J Exp Med. 2014 Jun 30;211(7):1421-31
All references(397)
Other
accession IDs
MGD-MRK-1833, MGI:2142241

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory