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Ccne1
Gene Detail
 Symbol
Name
ID
Ccne1
cyclin E1
MGI:88316
Synonyms CycE1, cyclin E
Feature Type protein coding gene
Genetic Map
Chromosome 7
25.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr7:38097984-38107534 bp, - strand
From VEGA annotation of GRCm38

  9551 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14452  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cyclin, A/B/D/E types
Gene Tree: Ccne1

Human
homologs
Human Homolog CCNE1, cyclin E1
NCBI Gene ID 898
neXtProt AC  NX_P24864
Human Synonyms  CCNE
Human Chr (Location)  19q12; chr19:29811898-29824317 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(18) Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display no abnormal phenotype.
 
Interactions
Ccne1 interacts with 119 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell cycle, cell division, ...
Component centrosome, cyclin-dependent protein kinase holoenzyme complex, ...
Function cyclin-dependent protein serine/threonine kinase regulator activity, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (81 records)
Data Summary: Results (173)    Tissues (65)    Images (85)
Theiler Stages: 1, 2, 3, 4, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 69
RNA in situ 39
Western blot 16
RT-PCR 49
cDNA source data(62)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) Genomic(1) cDNA(63) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022262 (Evidence)
Ensembl Gene ModelENSMUSG00000002068 (Evidence)
Entrez Gene12447 (Evidence)
UniGene16110
DFCITC1579342, TC1726923
DoTSDT.55100395
NIA Mouse Gene IndexU028449
Consensus CDS ProjectCCDS39914.1
International Mouse Knockout Project StatusCcne1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022262 VEGA Gene Model | MGI Sequence Detail 9551 C57BL/6J ±  kb
transcript OTTMUST00000053001 VEGA | MGI Sequence Detail 2000 Not Applicable 
polypeptide OTTMUSP00000025179 VEGA | MGI Sequence Detail 408 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014400 Cyclin A/B/D/E
InterPro IPR004367 Cyclin, C-terminal domain
InterPro IPR013763 Cyclin-like
InterPro IPR006671 Cyclin, N-terminal
Protein Ontology PR:000005125 G1/S-specific cyclin-E1
References (Earliest) J:18661 Damjanov I, et al., Molecular cloning and characterization of murine cyclin E. Biochem Biophys Res Commun. 1994 Jun 15;201(2):994-1000
(Latest) J:205333 Otero JJ, et al., Cerebellar cortical lamination and foliation require cyclin A2. Dev Biol. 2014 Jan 15;385(2):328-39
All references(149)
Other
accession IDs
MGD-MRK-1828, MGI:2142245

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory