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Ccne1 Gene Detail
Summary
  • Symbol
    Ccne1
  • Name
    cyclin E1
  • Synonyms
    CycE1, cyclin E
  • Feature Type
    protein coding gene
  • IDs
    MGI:88316
    NCBI Gene: 12447
  • Gene Overview
    MyGene.info: CCNE1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:38097984-38107490 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 25.35 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88316
protein coding gene Chr7:38097984-38107534 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032100
protein coding gene Chr7:37642475-37654388 (-)
A/J MGP_AJ_G0032080
protein coding gene Chr7:36592618-36602462 (-)
AKR/J MGP_AKRJ_G0032013
protein coding gene Chr7:37503955-37515649 (-)
BALB/cJ MGP_BALBcJ_G0032087
protein coding gene Chr7:36905572-36915299 (-)
C3H/HeJ MGP_C3HHeJ_G0031804
protein coding gene Chr7:38387727-38398497 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032564
protein coding gene Chr7:39470989-39481229 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029597
protein coding gene Chr7:37303772-37313640 (-)
CAST/EiJ MGP_CASTEiJ_G0031139
protein coding gene Chr7:29638463-29665619 (-)
CBA/J MGP_CBAJ_G0031772
protein coding gene Chr7:40721061-40730596 (-)
DBA/2J MGP_DBA2J_G0031924
protein coding gene Chr7:36426167-36435715 (-)
FVB/NJ MGP_FVBNJ_G0031877
protein coding gene Chr7:36349896-36359557 (-)
LP/J MGP_LPJ_G0032001
protein coding gene Chr7:37992919-38002485 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031917
protein coding gene Chr7:39525472-39537145 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032579
protein coding gene Chr7:37111018-37120565 (-)
PWK/PhJ MGP_PWKPhJ_G0030861
protein coding gene Chr7:29806978-29822616 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030696
protein coding gene Chr7:26668739-26678140 (-)
WSB/EiJ MGP_WSBEiJ_G0031249
protein coding gene Chr7:37625128-37635242 (-)



Homology
more
  • Human Ortholog
    CCNE1, cyclin E1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CCNE1, cyclin E1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CCNE, pCCNE1
  • Links
    NCBI Gene ID: 898
    neXtProt AC: NX_P24864
    UniProt: P24864

  • Chr Location
    19q12; chr19:29811994-29824317 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 4 genetic backgrounds
    40 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display no abnormal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12447 NCBI Gene Model | MGI Sequence Detail 9507 C57BL/6J ±  kb
    transcript NM_007633 RefSeq | MGI Sequence Detail 2022 Not Specified  
    polypeptide Q61457 UniProt | EBI | MGI Sequence Detail 408 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      Genomic 1
      cDNA 64
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1828, MGI:2142245
    References
    more
    • Summaries
      All 210
      Developmental Gene Expression 116
      Gene Ontology 21
      Phenotypes 23
    • Earliest
      J:18661 Damjanov I, et al., Molecular cloning and characterization of murine cyclin E. Biochem Biophys Res Commun. 1994 Jun 15;201(2):994-1000
    • Latest
      J:265935 Sonntag R, et al., Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9282-9287

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory