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Ccnb2 Gene Detail
Summary
  • Symbol
    Ccnb2
  • Name
    cyclin B2
  • Synonyms
    CycB2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88311
    NCBI Gene: 12442
  • Gene Overview
    MyGene.info: CCNB2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:70407692-70421547 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13856 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 39.53 cM, cytoband D
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CCNB2, cyclin B2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CCNB2, cyclin B2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HsT17299
  • Links
    NCBI Gene ID: 9133
    neXtProt AC: NX_O95067
    UniProt: O95067

  • Chr Location
    15q22.2; chr15:59105085-59125045 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in reduced body weight and reduced litter size. Homozygous pups are underrepresented in litters from a heterozygous intercross.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032218 Ensembl Gene Model | MGI Sequence Detail 13856 C57BL/6J ±  kb
    transcript ENSMUST00000034742 Ensembl | MGI Sequence Detail 1531 Not Applicable  
    polypeptide ENSMUSP00000034742 Ensembl | MGI Sequence Detail 398 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      48 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 94
      cDNA 91
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1823
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 17
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:1694 Hanley-Hyde J, et al., Expression of murine cyclin B1 mRNAs and genetic mapping of related genomic sequences. Genomics. 1992 Aug;13(4):1018-30
    • Latest
      J:255493 Strauss B, et al., Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis. J Cell Biol. 2018 Jan 2;217(1):179-193

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory