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Cck Gene Detail
Summary
  • Symbol
    Cck
  • Name
    cholecystokinin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88297
    NCBI Gene: 12424
  • Gene Overview
    MyGene.info: CCK
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:121489824-121495694 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 72.43 cM, cytoband F4
  • Mapping Data
    38 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88297
protein coding gene Chr9:121489824-121495694 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035442
protein coding gene Chr9:124428447-124434715 (-)
A/J MGP_AJ_G0035423
protein coding gene Chr9:119690574-119696406 (-)
AKR/J MGP_AKRJ_G0035356
protein coding gene Chr9:122869087-122874835 (-)
BALB/cJ MGP_BALBcJ_G0035419
protein coding gene Chr9:119599235-119605065 (-)
C3H/HeJ MGP_C3HHeJ_G0035126
protein coding gene Chr9:123333940-123339798 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035942
protein coding gene Chr9:127834460-127840320 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032824
protein coding gene Chr9:116851593-116857539 (-)
CAST/EiJ MGP_CASTEiJ_G0034431
protein coding gene Chr9:123370918-123376739 (-)
CBA/J MGP_CBAJ_G0035094
protein coding gene Chr9:132513829-132519613 (-)
DBA/2J MGP_DBA2J_G0035253
protein coding gene Chr9:119129092-119134866 (-)
FVB/NJ MGP_FVBNJ_G0035200
protein coding gene Chr9:118050748-118056577 (-)
LP/J MGP_LPJ_G0035332
protein coding gene Chr9:124763348-124769190 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035241
protein coding gene Chr9:133468061-133473913 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035961
protein coding gene Chr9:123320199-123326039 (-)
PWK/PhJ MGP_PWKPhJ_G0034135
protein coding gene Chr9:119589627-119595557 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033972
protein coding gene Chr9:123430269-123435724 (-)
WSB/EiJ MGP_WSBEiJ_G0034551
protein coding gene Chr9:123162858-123168610 (-)



Homology
more
  • Human Ortholog
    CCK, cholecystokinin
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CCK, cholecystokinin
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 885
    neXtProt AC: NX_P06307
    UniProt: P06307

  • Chr Location
    3p22.1; chr3:42257824-42266195 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice for one allele exhibit a significant decrease in prepulse inhibition while mice for another mutation appear normal but have increased enzyme levels of pancreatic amylase.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12424 NCBI Gene Model | MGI Sequence Detail 5871 C57BL/6J ±  kb
    transcript NM_001284508 RefSeq | MGI Sequence Detail 870 C57BL/6  
    polypeptide P09240 UniProt | EBI | MGI Sequence Detail 115 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 8
      cDNA 43
      Primer pair 4
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1804
    References
    more
    • Summaries
      All 202
      Developmental Gene Expression 64
      Gene Ontology 9
      Phenotypes 56
    • Earliest
      J:8001 Friedman J, et al., Differential expression of the mouse cholecystokinin gene during brain and gut development. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5593-7
    • Latest
      J:267059 Liu Y, et al., Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature. 2018 Sep 12;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory