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Cck Gene Detail
Summary
  • Symbol
    Cck
  • Name
    cholecystokinin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88297
    NCBI Gene: 12424
  • Gene Overview
    MyGene.info: CCK
Location & Maps
more
  • Sequence Map
    Chr9:121489825-121495689 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5865 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CCK, cholecystokinin
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CCK, cholecystokinin
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 885
    neXtProt AC: NX_P06307

  • Chr Location
    3p22.1; chr3:42257826-42266170 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    1
  • Targeted
    12
  • Incidental Mutations
    APF
Homozygous mice for one allele exhibit a significant decrease in prepulse inhibition while mice for another mutation appear normal but have increased enzyme levels of pancreatic amylase.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032532 Ensembl Gene Model | MGI Sequence Detail 5865 C57BL/6J ±  kb
transcript ENSMUST00000035120 Ensembl | MGI Sequence Detail 685 Not Applicable  
polypeptide ENSMUSP00000035120 Ensembl | MGI Sequence Detail 115 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    125 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005110 cholecystokinin
  • InterPro Domains
    IPR015499 Cholecystokinin-like
    IPR013152 Gastrin/cholecystokinin, conserved site
    IPR001651 Gastrin/cholecystokinin peptide hormone
Molecular
Reagents
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  • All nucleic 55
    Genomic 8
    cDNA 40
    Primer pair 4
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1804
References
more
  • Summaries
    All 150
    Developmental Gene Expression 57
    Gene Ontology 6
    Phenotypes 33
  • Earliest
    J:8001 Friedman J, et al., Differential expression of the mouse cholecystokinin gene during brain and gut development. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5593-7
  • Latest
    J:228422 Basu J, et al., Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition. Science. 2016 Jan 8;351(6269):aaa5694

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory