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Cck
Gene Detail
Symbol

Name
ID
Cck
cholecystokinin
MGI:88297
Feature Type
protein coding gene
Genetic Map
Chromosome 9
72.43 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(38)
Sequence Map
Chr9:121489825-121495689 bp, - strand
From Ensembl annotation of GRCm38

  5865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:583  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: cholecystokinin
Gene Tree: Cck

Human
homologs
Human Homolog CCK, cholecystokinin
NCBI Gene ID 885
neXtProt AC  NX_P06307
Human Chr (Location)  3p22.1; chr3:42257826-42266170 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(1) Targeted(12)
Incidental mutations (data from APF )
 
Homozygous mice for one allele exhibit a significant decrease in prepulse inhibition while mice for another mutation appear normal but have increased enzyme levels of pancreatic amylase.
 
Interactions
Cck interacts with 54 markers (Mir23a, Mir23b, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component axon, axon hillock, ...
Function hormone activity, neuropeptide hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (55 records)
Data Summary: Results (420)    Tissues (196)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 251
In situ reporter (knock in) 36
RT-PCR 86
RNase protection 45
cDNA source data(39)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) Genomic(8) cDNA(40) Primer pair(4) Other(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032532 (Evidence)
Entrez Gene12424 (Evidence)
UniGene2619
DFCITC1579955, TC1593494
DoTSDT.534519, DT.91432003, DT.94229104
NIA Mouse Gene IndexU031447
Consensus CDS ProjectCCDS23631.1
International Mouse Knockout Project StatusCck
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032532 Ensembl Gene Model | MGI Sequence Detail 5865 C57BL/6J ±  kb
transcript ENSMUST00000035120 Ensembl | MGI Sequence Detail 685 Not Applicable 
polypeptide ENSMUSP00000035120 Ensembl | MGI Sequence Detail 115 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(9) : SNPs within 2kb(126 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015499 Cholecystokinin
InterPro IPR013152 Gastrin/cholecystokinin, conserved site
InterPro IPR001651 Gastrin/cholecystokinin peptide hormone
Protein Ontology PR:000005110 cholecystokinin
References
(Earliest) J:8001 Friedman J, et al., Differential expression of the mouse cholecystokinin gene during brain and gut development. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5593-7
(Latest) J:213252 Maksimovic S, et al., Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors. Nature. 2014 May 29;509(7502):617-21
All references(149)
Other
accession IDs
MGD-MRK-1804

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory