Cck
Gene Detail

Symbol Name ID

Cck cholecystokinin MGI:88297

Feature Type

protein coding gene

Genetic Map

Chromosome 9

72.43 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(38)

Sequence Map

Chr9:121489825-121495689 bp, - strand From Ensembl annotation of GRCm38   5865 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:583  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: cholecystokinin
Gene Tree: Cck

Human homologs

Human Homolog		CCK, cholecystokinin
NCBI Gene ID		885
neXtProt AC		NX_P06307
Human Chr (Location)		3p22.1; chr3:42299318-42307662 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(11) Gene trapped(1)
 

Homozygous mice for one allele exhibit a significant decrease in prepulse inhibition while mice for another mutation appear normal but have increased enzyme levels of pancreatic amylase.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	axon, axon hillock, ...
Function	DNA binding, hormone activity, ...

External Resources: FuncBase

Expression

Literature Summary: (51 records)
Data Summary: Results (420)    Tissues (194)    Images (64)
Theiler Stages: 17, 19, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	251
In situ reporter (knock in)	36
RT-PCR	86
RNase protection	45

cDNA source data(39)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(56) Genomic(8) cDNA(40) Primer pair(4) Other(4)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032532 (Evidence)
Entrez Gene	12424 (Evidence)
UniGene	2619
DFCI	TC1579955, TC1593494
DoTS	DT.534519, DT.91432003, DT.94229104
NIA Mouse Gene Index	U031447
Consensus CDS Project	CCDS23631.1
International Mouse Knockout Project Status	Cck

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032532	Ensembl Gene Model | MGI Sequence Detail	5865	C57BL/6J
transcript	ENSMUST00000035120	Ensembl | MGI Sequence Detail	685	Not Applicable
polypeptide	ENSMUSP00000035120	Ensembl | MGI Sequence Detail	115	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(9) : SNPs(74 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015499	Cholecystokinin
InterPro	IPR013152	Gastrin/cholecystokinin, conserved site
InterPro	IPR001651	Gastrin/cholecystokinin peptide hormone
InterPro	IPR015893	Tetracycline transcriptional regulator, TetR-like, C-terminal
Protein Ontology	PR:000005110	cholecystokinin

References

(Earliest) J:8001 Friedman J, et al., Differential expression of the mouse cholecystokinin gene during brain and gut development. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5593-7
(Latest) J:192870 Biau S, et al., Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling. Biol Open. 2013;2:144-155
All references(138)

Other accession IDs

MGD-MRK-1804