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Cck
Gene Detail
Symbol

Name
ID
Cck
cholecystokinin
MGI:88297
Feature Type
protein coding gene
Genetic Map
Chromosome 9
72.43 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(38)
Sequence Map
Chr9:121489825-121495689 bp, - strand
From Ensembl annotation of GRCm38

  5865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:583  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CCK
Protein SuperFamily: cholecystokinin
Gene Tree: Cck

Human
homologs
CCK, cholecystokinin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 885
neXtProt AC: NX_P06307

Human Chr (Location): 3p22.1; chr3:42257826-42266170 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(1) Targeted(12)
Incidental mutations (data from APF )
 
Homozygous mice for one allele exhibit a significant decrease in prepulse inhibition while mice for another mutation appear normal but have increased enzyme levels of pancreatic amylase.
 
Interactions
Cck interacts with 54 markers (Mir23a, Mir23b, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component axon, axon hillock, ...
Function hormone activity, neuropeptide hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (57 records)
Data Summary: Results (487)    Tissues (234)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 316
In situ reporter (knock in) 36
RT-PCR 86
RNase protection 45
cDNA source data(39)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100497815 ; ZFIN ccka, cckb    NEW 
Molecular
reagents
All nucleic(55) Genomic(8) cDNA(40) Primer pair(4) Other(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000032532 (Evidence)
Entrez Gene 12424 (Evidence)
UniGene 2619
DFCI TC1579955, TC1593494
DoTS DT.534519, DT.91432003, DT.94229104
NIA Mouse Gene Index U031447
Consensus CDS Project CCDS23631.1
International Mouse Phenotyping Consortium Status Cck
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032532 Ensembl Gene Model | MGI Sequence Detail 5865 C57BL/6J ±  kb
transcript ENSMUST00000035120 Ensembl | MGI Sequence Detail 685 Not Applicable 
polypeptide ENSMUSP00000035120 Ensembl | MGI Sequence Detail 115 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(9) : SNPs within 2kb(126 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015499 Cholecystokinin
InterPro IPR013152 Gastrin/cholecystokinin, conserved site
InterPro IPR001651 Gastrin/cholecystokinin peptide hormone
Protein Ontology PR:000005110 cholecystokinin
References
(Earliest) J:8001 Friedman J, et al., Differential expression of the mouse cholecystokinin gene during brain and gut development. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5593-7
(Latest) J:220523 Harris JA, et al., Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits. 2014;8:76
All references(150)
Other
accession IDs
MGD-MRK-1804

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory