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Cbx2 Gene Detail
Summary
  • Symbol
    Cbx2
  • Name
    chromobox 2
  • Synonyms
    M33
  • Feature Type
    protein coding gene
  • IDs
    MGI:88289
    NCBI Gene: 12416
  • Gene Overview
    MyGene.info: CBX2
Location & Maps
more
  • Sequence Map
    Chr11:119022962-119031270 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8309 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.33 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CBX2, chromobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CBX2, chromobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDCA6, M33, SRXY5
  • Links
    NCBI Gene ID: 84733
    neXtProt AC: NX_Q14781

  • Chr Location
    17q25.3; chr17:79777188-79787650 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7256
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CBX2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CBX2 associations

Human Disease Mouse Models
       46,xy Sex Reversal 5; SRXY5   OMIM: 613080
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations cause malformations of the axial skeletal, reduced viability, poor growth and male to female sex reversal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003981 VEGA Gene Model | MGI Sequence Detail 8309 C57BL/6J ±  kb
transcript OTTMUST00000008845 VEGA | MGI Sequence Detail 3807 Not Applicable  
polypeptide OTTMUSP00000004311 VEGA | MGI Sequence Detail 519 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 81
    Genomic 5
    cDNA 73
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1793
References
more
  • Summaries
    All 63
    Developmental Gene Expression 21
    Gene Ontology 8
    Phenotypes 17
  • Earliest
    J:783 Pearce JJ, et al., The mouse has a Polycomb-like chromobox gene. Development. 1992 Apr;114(4):921-9
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory