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Cbx2
Gene Detail
Symbol

Name
ID
Cbx2
chromobox 2
MGI:88289
Synonyms
M33
Feature Type
protein coding gene
Genetic Map
Chromosome 11
83.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:119022962-119031270 bp, + strand
From VEGA annotation of GRCm38

  8309 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CBX2
Gene Tree: Cbx2

Human
homologs
CBX2, chromobox homolog 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84733
neXtProt AC: NX_Q14781

Human Synonyms: CDCA6, M33, SRXY5

Human Chr (Location): 17q25.3; chr17:79777188-79787650 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CBX2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , CvDC )
 
Mutations cause malformations of the axial skeletal, reduced viability, poor growth and male to female sex reversal.
 
Interactions
Cbx2 interacts with 265 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process chromatin modification, development of primary sexual characteristics, ...
Component euchromatin, heterochromatin, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (83)    Tissues (56)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 44
Western blot 22
RT-PCR 11
cDNA source data(72)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cbx2 ; ZFIN cbx2    NEW 
Molecular
reagents
All nucleic(81) Genomic(5) cDNA(73) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000003981 (Evidence)
Ensembl Gene Model ENSMUSG00000025577 (Evidence)
Entrez Gene 12416 (Evidence)
UniGene 14547
DFCI TC1577340
DoTS DT.97377486
NIA Mouse Gene Index U043249
Consensus CDS Project CCDS25708.1
International Mouse Phenotyping Consortium Status Cbx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003981 VEGA Gene Model | MGI Sequence Detail 8309 C57BL/6J ±  kb
transcript OTTMUST00000008845 VEGA | MGI Sequence Detail 3807 Not Applicable 
polypeptide OTTMUSP00000004311 VEGA | MGI Sequence Detail 519 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017956 AT hook, DNA-binding motif
InterPro IPR000953 Chromo/chromo shadow domain
InterPro IPR023780 Chromo domain
InterPro IPR023779 Chromo domain, conserved site
InterPro IPR016197 Chromo domain-like
Protein Ontology PR:000005083 chromobox protein homolog 2
References
(Earliest) J:783 Pearce JJ, et al., The mouse has a Polycomb-like chromobox gene. Development. 1992 Apr;114(4):921-9
(Latest) J:204987 Isono K, et al., SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing. Dev Cell. 2013 Sep 30;26(6):565-77
All references(67)
Other
accession IDs
MGD-MRK-1793

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory