Cbx2
Gene Detail

Symbol Name ID

Cbx2 chromobox 2 MGI:88289

Synonyms

M33

Feature Type

protein coding gene

Genetic Map

Chromosome 11

83.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:119022962-119031270 bp, + strand From VEGA annotation of GRCm38   8309 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cbx2

Human homologs

Human Homolog		CBX2, chromobox homolog 2
NCBI Gene ID		84733
neXtProt AC		NX_Q14781
Human Synonyms		CDCA6, M33, SRXY5
Human Chr (Location)		17q25.3; chr17:77751977-77761449 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CBX2

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mutations cause malformations of the axial skeletal, reduced viability, poor growth and male to female sex reversal.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	chromatin modification, development of primary sexual characteristics, ...
Component	heterochromatin, nucleus, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (90)    Tissues (59)    Images (22)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 19, 20, 21, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	44
Western blot	22
RT-PCR	18

cDNA source data(72)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(81) Genomic(5) cDNA(73) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000003981 (Evidence)
Ensembl Gene Model	ENSMUSG00000025577 (Evidence)
Entrez Gene	12416 (Evidence)
UniGene	14547
DFCI	TC1577340
DoTS	DT.97377486
NIA Mouse Gene Index	U043249
Consensus CDS Project	CCDS25708.1
International Mouse Knockout Project Status	Cbx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003981	VEGA Gene Model | MGI Sequence Detail	8309	C57BL/6J
transcript	OTTMUST00000008845	VEGA | MGI Sequence Detail	3807	Not Applicable
polypeptide	OTTMUSP00000004311	VEGA | MGI Sequence Detail	519	Not Applicable

All sequences(25) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(3 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017956	AT hook, DNA-binding motif
InterPro	IPR023780	Chromo domain
InterPro	IPR023779	Chromo domain, conserved site
InterPro	IPR016197	Chromo domain-like
InterPro	IPR000953	Chromo domain/shadow
Protein Ontology	PR:000005083	chromobox protein 2

References

(Earliest) J:783 Pearce JJ, et al., The mouse has a Polycomb-like chromobox gene. Development. 1992 Apr;114(4):921-9
(Latest) J:191095 Gierl MS, et al., GADD45G functions in male sex determination by promoting p38 signaling and Sry expression. Dev Cell. 2012 Nov 13;23(5):1032-42
All references(63)

Other accession IDs

MGD-MRK-1793