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Cbx2 Gene Detail
Summary
  • Symbol
    Cbx2
  • Name
    chromobox 2
  • Synonyms
    M33
  • Feature Type
    protein coding gene
  • IDs
    MGI:88289
    NCBI Gene: 12416
  • Gene Overview
    MyGene.info: CBX2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:119023019-119031275 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88289
protein coding gene Chr11:119022962-119031275 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019472
protein coding gene Chr11:123365357-123374748 (+)
A/J MGP_AJ_G0019440
protein coding gene Chr11:117918500-117926808 (+)
AKR/J MGP_AKRJ_G0019410
protein coding gene Chr11:121475261-121483569 (+)
BALB/cJ MGP_BALBcJ_G0019415
protein coding gene Chr11:118278161-118286476 (+)
C3H/HeJ MGP_C3HHeJ_G0019221
protein coding gene Chr11:121789595-121797906 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019864
protein coding gene Chr11:127132792-127142875 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017489
protein coding gene Chr11:114914465-114922792 (+)
CAST/EiJ MGP_CASTEiJ_G0018775
protein coding gene Chr11:123231526-123241475 (+)
CBA/J MGP_CBAJ_G0019192
protein coding gene Chr11:132072290-132080605 (+)
DBA/2J MGP_DBA2J_G0019304
protein coding gene Chr11:117295477-117303787 (+)
FVB/NJ MGP_FVBNJ_G0019296
protein coding gene Chr11:116952759-116961067 (+)
LP/J MGP_LPJ_G0019374
protein coding gene Chr11:123691851-123700182 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019329
protein coding gene Chr11:131035782-131045234 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019903
protein coding gene Chr11:122145966-122154274 (+)
PWK/PhJ MGP_PWKPhJ_G0018541
protein coding gene Chr11:118690716-118699717 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018333
protein coding gene Chr11:121887925-121896231 (+)
WSB/EiJ MGP_WSBEiJ_G0018827
protein coding gene Chr11:122111493-122120955 (+)



Homology
more
  • Human Ortholog
    CBX2, chromobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CBX2, chromobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDCA6, M33, SRXY5
  • Links
    NCBI Gene ID: 84733
    neXtProt AC: NX_Q14781
    UniProt: Q14781

  • Chr Location
    17q25.3; chr17:79776254-79787650 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7256
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CBX2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CBX2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations cause malformations of the axial skeletal, reduced viability, poor growth and male to female sex reversal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12416 NCBI Gene Model | MGI Sequence Detail 8257 C57BL/6J ±  kb
    transcript NM_007623 RefSeq | MGI Sequence Detail 3770 Not Specified  
    polypeptide P30658 UniProt | EBI | MGI Sequence Detail 519 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      Genomic 5
      cDNA 74
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1793
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 22
      Gene Ontology 10
      Phenotypes 19
    • Earliest
      J:783 Pearce JJ, et al., The mouse has a Polycomb-like chromobox gene. Development. 1992 Apr;114(4):921-9
    • Latest
      J:242063 Lau MS, et al., Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning. Science. 2017 Mar 10;355(6329):1081-1084

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory