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Cbx2
Gene Detail
 Symbol
Name
ID
Cbx2
chromobox 2
MGI:88289
Synonyms M33
Feature Type protein coding gene
Genetic Map
Chromosome 11
83.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:119022962-119031270 bp, + strand
From VEGA annotation of GRCm38

  8309 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cbx2

Human
homologs
Human Homolog CBX2, chromobox homolog 2
NCBI Gene ID 84733
neXtProt AC  NX_Q14781
Human Synonyms  CDCA6, M33, SRXY5
Human Chr (Location)  17q25.3; chr17:79778178-79787650 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CBX2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix )
 
Mutations cause malformations of the axial skeletal, reduced viability, poor growth and male to female sex reversal.
 
Interactions
Cbx2 interacts with 265 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process chromatin modification, development of primary sexual characteristics, ...
Component euchromatin, heterochromatin, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (83)    Tissues (56)    Images (22)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 19, 20, 21, 22, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 44
Western blot 22
RT-PCR 11
cDNA source data(72)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(81) Genomic(5) cDNA(73) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000003981 (Evidence)
Ensembl Gene ModelENSMUSG00000025577 (Evidence)
Entrez Gene12416 (Evidence)
UniGene14547
DFCITC1577340
DoTSDT.97377486
NIA Mouse Gene IndexU043249
Consensus CDS ProjectCCDS25708.1
International Mouse Knockout Project StatusCbx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003981 VEGA Gene Model | MGI Sequence Detail 8309 C57BL/6J ±  kb
transcript OTTMUST00000008845 VEGA | MGI Sequence Detail 3807 Not Applicable 
polypeptide OTTMUSP00000004311 VEGA | MGI Sequence Detail 519 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017956 AT hook, DNA-binding motif
InterPro IPR023780 Chromo domain
InterPro IPR023779 Chromo domain, conserved site
InterPro IPR016197 Chromo domain-like
InterPro IPR000953 Chromo domain/shadow
Protein Ontology PR:000005083 chromobox protein homolog 2
References (Earliest) J:783 Pearce JJ, et al., The mouse has a Polycomb-like chromobox gene. Development. 1992 Apr;114(4):921-9
(Latest) J:204987 Isono K, et al., SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing. Dev Cell. 2013 Sep 30;26(6):565-77
All references(68)
Other
accession IDs
MGD-MRK-1793

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory