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Ctnna2
Gene Detail
Symbol

Name
ID
Ctnna2
catenin (cadherin associated protein), alpha 2
MGI:88275
Synonyms
alpha N-catenin, alpha(N)-catenin, Catna, Catna2, chp
Feature Type
protein coding gene
Genetic Map
Chromosome 6
33.54 cM, cytoband B3-D
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr6:76881637-77979699 bp, - strand
From VEGA annotation of GRCm38

  1098063 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68394  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CTNNA2
Protein SuperFamily: alpha-catenin
Gene Tree: Ctnna2

Human
homologs
CTNNA2, catenin (cadherin-associated protein), alpha 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1496
neXtProt AC: NX_P26232

Human Synonyms: CAPR, CAP-R, CT114, CTNR

Human Chr (Location): 2p12-p11.1; chr2:79512934-80648868 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(2) Targeted(2)
Genomic Mutations involving Ctnna2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Animals homozygous for a mutation of this gene exhibit ataxia, reduced body weight, reduced male fertility, and abnormalities of the brain which include a hypoplastic cerebellum, abnormal foliation pattern, ectopic Purkinje cells, and abnormal pyramidal cells in the hippocampus.
 
Phenotype Images(2)
Interactions
Ctnna2 interacts with 323 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process axonogenesis, brain morphogenesis, ...
Component actin cytoskeleton, adherens junction, ...
Function actin filament binding, cadherin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (444)    Tissues (184)    Images (74)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 40
RNA in situ 384
Western blot 14
RT-PCR 6
cDNA source data(60)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CTNNA2 ; Xenbase ctnna2    NEW 
Molecular
reagents
All nucleic(64) cDNA(62) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000034530 (Evidence)
Ensembl Gene Model ENSMUSG00000063063 (Evidence)
Entrez Gene 12386 (Evidence)
UniGene 34637
DoTS DT.101377477, DT.101734789, DT.102545976, DT.110482311, DT.529967, DT.97343227
NIA Mouse Gene Index U027499
PDB 4K1O, 4ONS
Consensus CDS Project CCDS20250.1, CCDS39521.1
International Mouse Phenotyping Consortium Status Ctnna2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034530 VEGA Gene Model | MGI Sequence Detail 1098063 C57BL/6J ±  kb
transcript OTTMUST00000087609 VEGA | MGI Sequence Detail 4162 Not Applicable 
polypeptide OTTMUSP00000047677 VEGA | MGI Sequence Detail 966 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(10) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(6556 from dbSNP Build 137)    SNPs within 2kb including multiple locations(6580)
Protein-related
information
ResourceIDDescription
InterPro IPR001033 Alpha-catenin
InterPro IPR006077 Vinculin/alpha-catenin
InterPro IPR000633 Vinculin, conserved site
Protein Ontology PR:000006007 catenin alpha-2
References
(Earliest) J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
(Latest) J:204591 Yamben IF, et al., Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse. Dev Biol. 2013 Dec 1;384(1):41-52
All references(83)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1772, MGD-MRK-1774, MGD-MRK-1973, MGD-MRK-36040, MGI:107473, MGI:2141432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory