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Ctnna2
Gene Detail
 Symbol
Name
ID
Ctnna2
catenin (cadherin associated protein), alpha 2
MGI:88275
Synonyms alpha N-catenin, alpha(N)-catenin, Catna, Catna2, chp
Feature Type protein coding gene
Genetic Map
Chromosome 6
33.54 cM, cytoband B3-D
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr6:76881637-77979699 bp, - strand
From VEGA annotation of GRCm38

  1098063 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68394  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: alpha-catenin
Gene Tree: Ctnna2

Human
homologs
Human Homolog CTNNA2, catenin (cadherin-associated protein), alpha 2
NCBI Gene ID 1496
neXtProt AC  NX_P26232
Human Synonyms  CAPR, CAP-R, CT114, CTNR
Human Chr (Location)  2p12-p11.1; chr2:79512934-80648868 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a mutation of this gene exhibit ataxia, reduced body weight, reduced male fertility, and abnormalities of the brain which include a hypoplastic cerebellum, abnormal foliation pattern, ectopic Purkinje cells, and abnormal pyramidal cells in the hippocampus.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process axonogenesis, brain morphogenesis, ...
Component actin cytoskeleton, adherens junction, ...
Function cadherin binding, structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (444)    Tissues (183)    Images (74)
Theiler Stages: 13, 15, 16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 40
RNA in situ 384
Western blot 14
RT-PCR 6
cDNA source data(60)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(64) cDNA(62) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000034530 (Evidence)
Ensembl Gene ModelENSMUSG00000063063 (Evidence)
Entrez Gene12386 (Evidence)
UniGene34637
DoTSDT.101377477, DT.101734789, DT.102545976, DT.110482311, DT.529967, DT.97343227
NIA Mouse Gene IndexU027499
PDB4K1O, 4ONS
Consensus CDS ProjectCCDS20250.1, CCDS39521.1
International Mouse Knockout Project StatusCtnna2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034530 VEGA Gene Model | MGI Sequence Detail 1098063 C57BL/6J ±  kb
transcript OTTMUST00000087609 VEGA | MGI Sequence Detail 4162 Not Applicable 
polypeptide OTTMUSP00000047677 VEGA | MGI Sequence Detail 966 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(12) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(6556 from dbSNP Build 137)    SNPs within 2kb including multiple locations(6580)
Protein-related
information
ResourceIDDescription
InterPro IPR001033 Alpha-catenin
InterPro IPR006077 Vinculin/alpha-catenin
InterPro IPR000633 Vinculin, conserved site
Protein Ontology PR:000006007 catenin alpha-2
References (Earliest) J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
(Latest) J:204591 Yamben IF, et al., Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse. Dev Biol. 2013 Dec 1;384(1):41-52
All references(81)
Other
accession IDs
MGD-MRK-1772, MGD-MRK-1774, MGD-MRK-1973, MGD-MRK-36040, MGI:107473, MGI:2141432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory