Ctnna2
Gene Detail

Symbol Name ID

Ctnna2 catenin (cadherin associated protein), alpha 2 MGI:88275

Synonyms

alpha N-catenin, alpha(N)-catenin, Catna, Catna2, chp

Feature Type

protein coding gene

Genetic Map

Chromosome 6

33.54 cM, cytoband B3-D
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr6:76881637-77979699 bp, - strand From VEGA annotation of GRCm38   1098063 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68394  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: alpha-catenin
Gene Tree: Ctnna2

Human homologs

Human Homolog		CTNNA2, catenin (cadherin-associated protein), alpha 2
NCBI Gene ID		1496
neXtProt AC		NX_P26232
Human Synonyms		CAPR, CAP-R, CT114, CTNR
Human Chr (Location)		2p12-p11.1; chr2:79740060-80875993 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Spontaneous(1)
 

Animals homozygous for a mutation of this gene exhibit ataxia, reduced body weight, reduced male fertility, and abnormalities of the brain which include a hypoplastic cerebellum, abnormal foliation pattern, ectopic Purkinje cells, and abnormal pyramidal cells in the hippocampus.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	axonogenesis, brain morphogenesis, ...
Component	actin cytoskeleton, adherens junction, ...
Function	cadherin binding, structural molecule activity

External Resources: FuncBase

Expression

Literature Summary: (25 records)
Data Summary: Results (388)    Tissues (144)    Images (41)
Theiler Stages: 17, 20, 22, 23, 24, 26

Assay Type	Results
Immunohistochemistry	5
RNA in situ	370
Western blot	7
RT-PCR	6

cDNA source data(60)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(63) cDNA(61) Primer pair(1) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000034530 (Evidence)
Ensembl Gene Model	ENSMUSG00000063063 (Evidence)
Entrez Gene	12386 (Evidence)
UniGene	34637
DoTS	DT.101377477, DT.101734789, DT.102545976, DT.110482311, DT.529967, DT.97343227
NIA Mouse Gene Index	U027499
Consensus CDS Project	CCDS20250.1, CCDS39521.1
International Mouse Knockout Project Status	Ctnna2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034530	VEGA Gene Model | MGI Sequence Detail	1098063	C57BL/6J
transcript	OTTMUST00000087609	VEGA | MGI Sequence Detail	4162	Not Applicable
polypeptide	OTTMUSP00000047677	VEGA | MGI Sequence Detail	966	Not Applicable

All sequences(50) RefSeq(6) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(5678 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001033	Alpha-catenin
InterPro	IPR006077	Vinculin/alpha-catenin
InterPro	IPR000633	Vinculin, conserved site
Protein Ontology	PR:000006007	catenin alpha-2

References

(Earliest) J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
(Latest) J:185949 Licatalosi DD, et al., Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev. 2012 Jul 15;26(14):1626-42
All references(76)

Other accession IDs

MGD-MRK-1772, MGD-MRK-1774, MGD-MRK-1973, MGD-MRK-36040, MGI:107473, MGI:2141432