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Ctnna1
Gene Detail
Symbol

Name
ID
Ctnna1
catenin (cadherin associated protein), alpha 1
MGI:88274
Synonyms
2010010M04Rik, alpha E catenin, alpha(E)-catenin, Catna1
Feature Type
protein coding gene
Genetic Map
Chromosome 18
18.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:35118912-35254775 bp, + strand
From NCBI annotation of GRCm38

  135864 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1433  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CTNNA1
Protein SuperFamily: alpha-catenin
Gene Tree: Ctnna1

Human
homologs
CTNNA1, catenin (cadherin-associated protein), alpha 1, 102kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1495
neXtProt AC: NX_P35221

Human Synonyms: CAP102

Human Chr (Location): 5q31.2; chr5:138753396-138935034 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(175) : Gene trapped(173) Spontaneous(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality at the blastocyst stage. A conditional knockout in surface epithelium results in defects in hair follicle development and epidermal morphogenesis.
 
Interactions
Ctnna1 interacts with 156 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process actin filament organization, apical junction assembly, ...
Component acrosomal vesicle, actin cytoskeleton, ...
Function actin filament binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (48 records)
Data Summary: Results (210)    Tissues (197)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 70
RNA in situ 135
Western blot 5
cDNA source data(469)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ctnna1 ; ZFIN ctnna1    NEW 
Molecular
reagents
All nucleic(475) cDNA(474) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000037815 (Evidence)
Entrez Gene 12385 (Evidence)
UniGene 18962
DFCI TC1573949, TC1605261, TC1640468
NIA Mouse Gene Index U018559
PDB 1DOV, 1DOW, 1L7C, 4E17, 4E18, 4K1N
Consensus CDS Project CCDS29139.1
International Mouse Phenotyping Consortium Status Ctnna1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12385 NCBI Gene Model | MGI Sequence Detail 135864 C57BL/6J ±  kb
transcript NM_009818 RefSeq | MGI Sequence Detail 3713 129/Sv 
polypeptide P26231 UniProt | EBI | MGI Sequence Detail 906 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(411 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001033 Alpha-catenin
InterPro IPR006077 Vinculin/alpha-catenin
InterPro IPR000633 Vinculin, conserved site
Protein Ontology PR:000006006 catenin alpha-1
Graphical View of Protein Domain Structure
References
(Earliest) J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
(Latest) J:219824 Hendley AM, et al., p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. Dev Biol. 2015 Mar 1;399(1):41-53
All references(121)
Other
accession IDs
MGD-MRK-1773, MGI:1913796, MGI:2147175, MGI:2147284

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory