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Ctnna1
Gene Detail
Symbol

Name
ID
Ctnna1
catenin (cadherin associated protein), alpha 1
MGI:88274
Synonyms
2010010M04Rik, alpha E catenin, alpha(E)-catenin, Catna1
Feature Type
protein coding gene
Genetic Map
Chromosome 18
18.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:35118912-35254775 bp, + strand
From NCBI annotation of GRCm38

  135864 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1433  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: alpha-catenin
Gene Tree: Ctnna1

Human
homologs
Human Homolog CTNNA1, catenin (cadherin-associated protein), alpha 1, 102kDa
NCBI Gene ID 1495
neXtProt AC  NX_P35221
Human Synonyms  CAP102
Human Chr (Location)  5q31.2; chr5:138753418-138935034 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(175) : Gene trapped(173) Spontaneous(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality at the blastocyst stage. A conditional knockout in surface epithelium results in defects in hair follicle development and epidermal morphogenesis.
 
Interactions
Ctnna1 interacts with 156 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process apical junction assembly, cell adhesion, ...
Component acrosomal vesicle, actin cytoskeleton, ...
Function actin filament binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (44 records)
Data Summary: Results (210)    Tissues (197)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 70
RNA in situ 135
Western blot 5
cDNA source data(469)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(475) cDNA(474) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000037815 (Evidence)
Entrez Gene12385 (Evidence)
UniGene18962
DFCITC1573949, TC1605261, TC1640468
NIA Mouse Gene IndexU018559
PDB1DOV, 1DOW, 1L7C, 4K1N, 4E17, 4E18
Consensus CDS ProjectCCDS29139.1
International Mouse Knockout Project StatusCtnna1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12385 NCBI Gene Model | MGI Sequence Detail 135864 C57BL/6J ±  kb
transcript NM_009818 RefSeq | MGI Sequence Detail 3713 129/Sv 
polypeptide P26231 UniProt | EBI | MGI Sequence Detail 906 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(411 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001033 Alpha-catenin
InterPro IPR006077 Vinculin/alpha-catenin
InterPro IPR000633 Vinculin, conserved site
Protein Ontology PR:000006006 catenin alpha-1
Graphical View of Protein Domain Structure
References
(Earliest) J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
(Latest) J:204591 Yamben IF, et al., Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse. Dev Biol. 2013 Dec 1;384(1):41-52
All references(116)
Other
accession IDs
MGD-MRK-1773, MGI:1913796, MGI:2147175, MGI:2147284

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory