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Ctnna1 Gene Detail
Summary
  • Symbol
    Ctnna1
  • Name
    catenin (cadherin associated protein), alpha 1
  • Synonyms
    2010010M04Rik, alpha E catenin, alpha(E)-catenin, Catna1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88274
    NCBI Gene: 12385
Location & Maps
more
  • Sequence Map
    Chr18:35118912-35254775 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      135864 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 18.89 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CTNNA1, catenin alpha 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CTNNA1, catenin alpha 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAP102, MDPT2
  • Links
    NCBI Gene ID: 1495
    neXtProt AC: NX_P35221

  • Chr Location
    5q31.2; chr5:138753396-138935034 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Ctnna1 mouse models; 1 with human CTNNA1 associations

Human Disease Mouse Models
       Macular Dystrophy, Patterned, 2; MDPT2   OMIM: 608970 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 4 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    177
  • Chemically induced (ENU)
    1
  • Gene trapped
    174
  • Spontaneous
    1
  • Targeted
    1
  • Incidental Mutations
Homozygous mutation of this gene results in embryonic lethality at the blastocyst stage. A conditional knockout in surface epithelium results in defects in hair follicle development and epidermal morphogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12385 NCBI Gene Model | MGI Sequence Detail 135864 C57BL/6J ±  kb
transcript NM_009818 RefSeq | MGI Sequence Detail 3713 129/Sv  
polypeptide P26231 UniProt | EBI | MGI Sequence Detail 906 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    411 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 475
    cDNA 474
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1773, MGI:1913796, MGI:2147175, MGI:2147284
References
more
  • Summaries
    All 125
    Developmental Gene Expression 51
    Diseases 1
    Gene Ontology 22
    Phenotypes 26
  • Earliest
    J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
  • Latest
    J:229014 Marty-Santos L, et al., Pdx1 regulates pancreas tubulogenesis and E-cadherin expression. Development. 2016 Jan 1;143(1):101-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory