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Ctnna1 Gene Detail
Summary
  • Symbol
    Ctnna1
  • Name
    catenin alpha 1
  • Synonyms
    2010010M04Rik, alpha E catenin, alpha(E)-catenin, catenin (cadherin associated protein), alpha 1, Catna1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88274
    NCBI Gene: 12385
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35251955-35387829 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 18.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    411 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88274
 protein coding gene Chr18:35251912-35387832 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024256
 protein coding gene Chr18:33391781-33538181 (+)
A/J MGP_AJ_G0024222
 protein coding gene Chr18:32240211-32376846 (+)
AKR/J MGP_AKRJ_G0024190
 protein coding gene Chr18:33167899-33302888 (+)
BALB/cJ MGP_BALBcJ_G0024222
 protein coding gene Chr18:32300002-32439981 (+)
C3H/HeJ MGP_C3HHeJ_G0023989
 protein coding gene Chr18:33188752-33333515 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024664
 protein coding gene Chr18:34632145-34774874 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022104
 protein coding gene Chr18:32384566-32516134 (+)
CAST/EiJ MGP_CASTEiJ_G0023464
 protein coding gene Chr18:33173620-33316186 (+)
CBA/J MGP_CBAJ_G0023957
 protein coding gene Chr18:35610846-35757401 (+)
DBA/2J MGP_DBA2J_G0024089
 protein coding gene Chr18:31895781-32032404 (+)
FVB/NJ MGP_FVBNJ_G0024056
 protein coding gene Chr18:31582094-31718294 (+)
LP/J MGP_LPJ_G0024171
 protein coding gene Chr18:33467107-33607988 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024084
 protein coding gene Chr18:36851668-36997820 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024712
 protein coding gene Chr18:33000818-33138903 (+)
PWK/PhJ MGP_PWKPhJ_G0023208
 protein coding gene Chr18:32116065-32253822 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023016
 protein coding gene Chr18:33270323-33403467 (+)
WSB/EiJ MGP_WSBEiJ_G0023527
 protein coding gene Chr18:32926816-33068109 (+)



Homology
more
  • Human Ortholog
    CTNNA1, catenin alpha 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTNNA1, catenin alpha 1
  • Synonyms
    CAP102, MDBS2, MDPT2
  • Links
    NCBI Gene ID: 1495
    neXtProt AC: NX_P35221
    UniProt: P35221

  • Chr Location
    5q31.2; chr5:138610967-138935034 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ctnna1 mouse models; 1 with human CTNNA1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 5 alleles in 8 genetic backgrounds
    11 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality at the blastocyst stage. A conditional knockout in surface epithelium results in defects in hair follicle development and epidermal morphogenesis. Inducible KO in endothelial cells reduces lifespan and affects retinal angiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    952
  • Tissues
    214
  • cDNA Data
    471
  • Literature Summary
    83
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12385 NCBI Gene Model | MGI Sequence Detail 135875 C57BL/6J ±  kb
    transcript NM_009818 RefSeq | MGI Sequence Detail 3713 129/Sv  
    polypeptide P26231 UniProt | EBI | MGI Sequence Detail 906 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 478
      cDNA 476
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1773, MGI:1913796, MGI:2147175, MGI:2147284
    References
    more
    • Summaries
      All 186
      Developmental Gene Expression 83
      Diseases 2
      Gene Ontology 24
      Phenotypes 43
    • Earliest
      J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
    • Latest
      J:343674 Dehn AS, et al., Epithelial mechanics are maintained by inhibiting cell fusion with age in Drosophila. J Cell Sci. 2023 Oct 15;136(20)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory