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Car3
Gene Detail
Symbol

Name
ID
Car3
carbonic anhydrase 3
MGI:88270
Synonyms
Car-3
Feature Type
protein coding gene
Genetic Map
Chromosome 3
3.22 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:14863512-14872523 bp, + strand
From VEGA annotation of GRCm38

  9012 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31298  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog

HCOP human homology predictions: CA3
Protein SuperFamily: carbonate dehydratase
Gene Tree: Car3

Human
homologs
CA3, carbonic anhydrase III
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 761
neXtProt AC: NX_P07451

Human Synonyms: CAIII, Car3

Human Chr (Location): 8q21.2; chr8:85438827-85449040 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele are viable and fertile and exhibit a normal life span and a normal response to hyperoxic challenge. Mutant muscles display shorter half-relaxation times for both single and tetanic twitches but show normal fatigability.
 
Interactions
Car3 interacts with 90 markers (Mir1a-1, Mir1a-2, Mir29a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process one-carbon metabolic process, protein dephosphorylation, ...
Component cytoplasm, cytosol
Function carbonate dehydratase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (244)    Tissues (126)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 242
RT-PCR 2
cDNA source data(440)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ca3    NEW 
Molecular
reagents
All nucleic(444) cDNA(441) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000051086 (Evidence)
Ensembl Gene Model ENSMUSG00000027559 (Evidence)
Entrez Gene 12350 (Evidence)
UniGene 300
DFCI TC1573384, TC1587998, TC1609265
DoTS DT.101409189, DT.537790, DT.87049174, DT.87054659, DT.91358431
NIA Mouse Gene Index U003041
EC 4.2.1.1
Consensus CDS Project CCDS17250.1
International Mouse Phenotyping Consortium Status Car3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051086 VEGA Gene Model | MGI Sequence Detail 9012 C57BL/6J ±  kb
transcript OTTMUST00000129481 VEGA | MGI Sequence Detail 1679 Not Applicable 
polypeptide OTTMUSP00000069536 VEGA | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(3) : SNPs within 2kb(206 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR023561 Carbonic anhydrase, alpha-class
InterPro IPR018338 Carbonic anhydrase, alpha-class, conserved site
InterPro IPR018441 Carbonic anhydrase, CA3
Protein Ontology PR:000004919 carbonic anhydrase 3
References
(Earliest) J:62609 Kelly CD, et al., Characterisation of cDNA clones for rat muscle carbonic anhydrase III. Biosci Rep. 1988 Oct;8(5):401-6
(Latest) J:220108 Marotta P, et al., The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells. Mol Cell Endocrinol. 2014 Oct;396(1-2):26-36
All references(61)
Other
accession IDs
MGD-MRK-1761, MGD-MRK-1764, MGI:2140035

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory