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Car3 Gene Detail
Summary
  • Symbol
    Car3
  • Name
    carbonic anhydrase 3
  • Synonyms
    Car-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:88270
    NCBI Gene: 12350
Location & Maps
more
  • Sequence Map
    Chr3:14863512-14872523 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9012 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 3.22 cM, cytoband A2
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CA3, carbonic anhydrase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CA3, carbonic anhydrase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAIII, Car3
  • Links
    NCBI Gene ID: 761
    neXtProt AC: NX_P07451

  • Chr Location
    8q21.2; chr8:85438827-85449040 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile and exhibit a normal life span and a normal response to hyperoxic challenge. Mutant muscles display shorter half-relaxation times for both single and tetanic twitches but show normal fatigability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051086 VEGA Gene Model | MGI Sequence Detail 9012 C57BL/6J ±  kb
transcript OTTMUST00000129481 VEGA | MGI Sequence Detail 1679 Not Applicable  
polypeptide OTTMUSP00000069536 VEGA | MGI Sequence Detail 260 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    203 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 444
    cDNA 441
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-1761, MGD-MRK-1764, MGI:2140035
References
more
  • Summaries
    All 59
    Developmental Gene Expression 20
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:62609 Kelly CD, et al., Characterisation of cDNA clones for rat muscle carbonic anhydrase III. Biosci Rep. 1988 Oct;8(5):401-6
  • Latest
    J:220483 Carter WG, et al., Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury. Biochem Biophys Res Commun. 2015 Mar 13;458(3):626-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory