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Car3
Gene Detail
Symbol

Name
ID
Car3
carbonic anhydrase 3
MGI:88270
Synonyms
Car-3
Feature Type
protein coding gene
Genetic Map
Chromosome 3
3.22 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:14863538-14872351 bp, + strand
From Ensembl annotation of GRCm38

  8814 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31298  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog

Protein SuperFamily: carbonate dehydratase
Gene Tree: Car3

Human
homologs
Human Homolog CA3, carbonic anhydrase III, muscle specific
NCBI Gene ID 761
neXtProt AC  NX_P07451
Human Synonyms  CAIII, Car3
Human Chr (Location)  8q21.2; chr8:85438827-85449040 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and fertile and exhibit a normal life span and a normal response to hyperoxic challenge. Mutant muscles display shorter half-relaxation times for both single and tetanic twitches but show normal fatigability.
 
Interactions
Car3 interacts with 91 markers (Mir1a-1, Mir1a-2, Mir29a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process one-carbon metabolic process, response to oxidative stress
Component cytoplasm, cytosol
Function carbonate dehydratase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (244)    Tissues (126)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 242
RT-PCR 2
cDNA source data(440)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(444) cDNA(441) Primer pair(3)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000027559 (Evidence)
Entrez Gene12350 (Evidence)
UniGene300
DFCITC1573384, TC1587998, TC1609265
DoTSDT.101409189, DT.537790, DT.87049174, DT.87054659, DT.91358431
NIA Mouse Gene IndexU003041
EC4.2.1.1
Consensus CDS ProjectCCDS17250.1
International Mouse Knockout Project StatusCar3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027559 Ensembl Gene Model | MGI Sequence Detail 8814 C57BL/6J ±  kb
transcript ENSMUST00000029076 Ensembl | MGI Sequence Detail 1507 Not Applicable 
polypeptide ENSMUSP00000029076 Ensembl | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(3) : SNPs within 2kb(201 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR023561 Carbonic anhydrase, alpha-class
InterPro IPR018338 Carbonic anhydrase, alpha-class, conserved site
InterPro IPR018441 Carbonic anhydrase, CA-III
Protein Ontology PR:000004919 carbonic anhydrase 3
References
(Earliest) J:62609 Kelly CD, et al., Characterisation of cDNA clones for rat muscle carbonic anhydrase III. Biosci Rep. 1988 Oct;8(5):401-6
(Latest) J:193048 Wu L, et al., A systematic survey of carbonic anhydrase mRNA expression during Mammalian inner ear development. Dev Dyn. 2013 Mar;242(3):269-80
All references(58)
Other
accession IDs
MGD-MRK-1761, MGD-MRK-1764, MGI:2140035

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory