About   Help   FAQ
Car1
Gene Detail
Symbol

Name
ID
Car1
carbonic anhydrase 1
MGI:88268
Synonyms
CA I, Car-1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
3.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr3:14766216-14808368 bp, - strand
From VEGA annotation of GRCm38

  42153 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: carbonate dehydratase
Gene Tree: Car1

Human
homologs
Human Homolog CA1, carbonic anhydrase I
NCBI Gene ID 759
neXtProt AC  NX_P00915
Human Synonyms  CAB, CA-I, Car1, HEL-S-11
Human Chr (Location)  8q21.2; chr8:85328229-85378113 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
This locus controls electrophoretic variation in red blood cells. The a allele determines a slow migrating form in C57BL/6, C3H/He and other strains; the b allele determines a fast form in IS/Cam, WB/Re, SM, M. m. castaneus and M. m. molossinus.
 
Interactions
Car1 interacts with 63 markers (Mir20a, Mir29b-2, Mir34b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process one-carbon metabolic process
Component cytoplasm, extracellular vesicular exosome
Function carbonate dehydratase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (146)    Tissues (145)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 146
cDNA source data(107)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(111) Genomic(3) cDNA(107) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026455 (Evidence)
Ensembl Gene ModelENSMUSG00000027556 (Evidence)
Entrez Gene12346 (Evidence)
UniGene273195
DFCITC1574839
DoTSDT.101385200, DT.494947
EC4.2.1.1
Consensus CDS ProjectCCDS17248.1
International Mouse Knockout Project StatusCar1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026455 VEGA Gene Model | MGI Sequence Detail 42153 C57BL/6J ±  kb
transcript OTTMUST00000112073 VEGA | MGI Sequence Detail 1194 Not Applicable 
polypeptide OTTMUSP00000062899 VEGA | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(382 from dbSNP Build 137)    SNPs within 2kb including multiple locations(406)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR023561 Carbonic anhydrase, alpha-class
InterPro IPR018338 Carbonic anhydrase, alpha-class, conserved site
InterPro IPR018442 Carbonic anhydrase, CA-I
Protein Ontology PR:000004912 carbonic anhydrase 1
References
(Earliest) J:13639 Biddle FG, Pro-1. Mouse News Lett. 1974;50:3
(Latest) J:193048 Wu L, et al., A systematic survey of carbonic anhydrase mRNA expression during Mammalian inner ear development. Dev Dyn. 2013 Mar;242(3):269-80
All references(52)
Other
accession IDs
MGD-MRK-1759, MGD-MRK-1762, MGI:2140006

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory