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Capns1 Gene Detail
Summary
  • Symbol
    Capns1
  • Name
    calpain, small subunit 1
  • Synonyms
    Capa4, Capa-4, Capn4, D7Ertd146e
  • Feature Type
    protein coding gene
  • IDs
    MGI:88266
    NCBI Gene: 12336
  • Gene Overview
    MyGene.info: CAPNS1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:30186936-30198811 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11876 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 17.31 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CAPNS1, calpain small subunit 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CAPNS1, calpain small subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1
  • Links
    NCBI Gene ID: 826
    neXtProt AC: NX_P04632
    UniProt: P04632

  • Chr Location
    19q13.12; chr19:36139926-36150353 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 6 alleles in 5 genetic backgrounds
    2 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality around E11.5. Mutant embryos exhibit cardiac developmental defects, reduced yolk sac vasculature, hemorrhaging in the area between the embryo and amnion, and accumulation of nucleated erythroid cells in the heart chambers, blood vessels, and developing liver.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022203 VEGA Gene Model | MGI Sequence Detail 11876 C57BL/6J ±  kb
    transcript OTTMUST00000052760 VEGA | MGI Sequence Detail 1600 Not Applicable  
    polypeptide OTTMUSP00000025058 VEGA | MGI Sequence Detail 268 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      198 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 318
      Genomic 1
      cDNA 316
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1753, MGD-MRK-1757, MGI:1098835
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 30
    • Earliest
      J:10758 Ohno S, et al., Four genes for the calpain family locate on four distinct human chromosomes. Cytogenet Cell Genet. 1990;53(4):225-9
    • Latest
      J:246551 Ni R, et al., Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy. Diabetes. 2016 Jan;65(1):255-68

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory