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Capns1
Gene Detail
Symbol

Name
ID
Capns1
calpain, small subunit 1
MGI:88266
Synonyms
Capa4, Capa-4, Capn4, D7Ertd146e
Feature Type
protein coding gene
Genetic Map
Chromosome 7
17.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:30186942-30195164 bp, - strand
From VEGA annotation of GRCm38

  8223 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1327  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: calpain, small subunit
Gene Tree: Capns1

Human
homologs
Human Homolog CAPNS1, calpain, small subunit 1
NCBI Gene ID 826
neXtProt AC  NX_P04632
Human Synonyms  CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1
Human Chr (Location)  19q13.12; chr19:36140016-36150353 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(35) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality around E11.5. Mutant embryos exhibit cardiac developmental defects, reduced yolk sac vasculature, hemorrahging in the area between the embryo and amnion, and accumulation of nucleated erythroid cells in the heart chambers, blood vessels, and developing liver.
 
Phenotype Images(2)
Interactions
Capns1 interacts with 83 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process proteolysis
Component cytoplasm, cytosol, ...
Function calcium-dependent cysteine-type endopeptidase activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (15)    Tissues (4)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
cDNA source data(316)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(318) Genomic(1) cDNA(316) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022203 (Evidence)
Ensembl Gene ModelENSMUSG00000001794 (Evidence)
Entrez Gene12336 (Evidence)
UniGene439782
DFCITC1571957
DoTSDT.101408793, DT.40180076
NIA Mouse Gene IndexU028370
Consensus CDS ProjectCCDS21082.1
International Mouse Knockout Project StatusCapns1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022203 VEGA Gene Model | MGI Sequence Detail 8223 C57BL/6J ±  kb
transcript OTTMUST00000052760 VEGA | MGI Sequence Detail 1546 Not Applicable 
polypeptide OTTMUSP00000025058 VEGA | MGI Sequence Detail 268 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(177 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000005022 calpain small subunit 1
References
(Earliest) J:10758 Ohno S, et al., Four genes for the calpain family locate on four distinct human chromosomes. Cytogenet Cell Genet. 1990;53(4):225-9
(Latest) J:209416 Kumar V, et al., Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model. Eur J Immunol. 2014 Mar;44(3):831-41
All references(70)
Other
accession IDs
MGD-MRK-1753, MGD-MRK-1757, MGI:1098835

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory