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Cap1 Gene Detail
Summary
  • Symbol
    Cap1
  • Name
    CAP, adenylate cyclase-associated protein 1 (yeast)
  • Feature Type
    protein coding gene
  • IDs
    MGI:88262
    NCBI Gene: 12331
  • Gene Overview
    MyGene.info: CAP1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:122859047-122886056 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 57.27 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88262
protein coding gene Chr4:122859047-122886071 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028728
protein coding gene Chr4:124239523-124267733 (-)
A/J MGP_AJ_G0028687
protein coding gene Chr4:119395023-119422270 (-)
AKR/J MGP_AKRJ_G0028641
protein coding gene Chr4:122614630-122645775 (-)
BALB/cJ MGP_BALBcJ_G0028710
protein coding gene Chr4:119974724-120001013 (-)
C3H/HeJ MGP_C3HHeJ_G0028425
protein coding gene Chr4:122739693-122769592 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029152
protein coding gene Chr4:129041501-129079488 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026425
protein coding gene Chr4:112640722-112665734 (-)
CAST/EiJ MGP_CASTEiJ_G0027857
protein coding gene Chr4:120731083-120760149 (-)
CBA/J MGP_CBAJ_G0028392
protein coding gene Chr4:132321847-132349642 (-)
DBA/2J MGP_DBA2J_G0028539
protein coding gene Chr4:119913578-119939931 (-)
FVB/NJ MGP_FVBNJ_G0028506
protein coding gene Chr4:118520558-118547176 (-)
LP/J MGP_LPJ_G0028640
protein coding gene Chr4:124517147-124545732 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028534
protein coding gene Chr4:137275957-137306009 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029189
protein coding gene Chr4:122981298-123008289 (-)
PWK/PhJ MGP_PWKPhJ_G0027579
protein coding gene Chr4:116294860-116321552 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027405
protein coding gene Chr4:118811769-118838625 (-)
WSB/EiJ MGP_WSBEiJ_G0027937
protein coding gene Chr4:123083785-123112326 (-)



Homology
more
  • Human Ortholog
    CAP1, cyclase associated actin cytoskeleton regulatory protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CAP1, cyclase associated actin cytoskeleton regulatory protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAP, CAP1-PEN
  • Links
    NCBI Gene ID: 10487
    neXtProt AC: NX_Q01518
    UniProt: Q01518

  • Chr Location
    1p34.2; chr1:40040070-40072649 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028656 Ensembl Gene Model | MGI Sequence Detail 27010 C57BL/6J ±  kb
transcript ENSMUST00000106255 Ensembl | MGI Sequence Detail 2737 Not Applicable  
polypeptide ENSMUSP00000101862 Ensembl | MGI Sequence Detail 474 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000005006 adenylyl cyclase-associated protein 1
  • PDB
  • InterPro Domains
    IPR001837 Adenylate cyclase-associated CAP
    IPR013912 Adenylate cyclase-associated CAP, C-terminal
    IPR036223 Adenylate cyclase-associated CAP, C-terminal superfamily
    IPR013992 Adenylate cyclase-associated CAP, N-terminal
    IPR036222 Adenylate cyclase-associated CAP, N-terminal domain superfamily
    IPR028415 Adenylyl cyclase-associated protein CAP1
    IPR028417 CAP, conserved site, C-terminal
    IPR018106 CAP, conserved site, N-terminal
    IPR006599 CARP motif
    IPR017901 C-CAP/cofactor C-like domain
    IPR016098 Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal
Molecular
Reagents
less
  • All nucleic 163
    cDNA 163

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1749
References
more
  • Summaries
    All 51
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:154091 Gogstad GO, et al., Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981 Sep 29;670(2):150-62
  • Latest
    J:218806 Jansen S, et al., Structure and mechanism of mouse cyclase-associated protein (CAP1) in regulating actin dynamics. J Biol Chem. 2014 Oct 31;289(44):30732-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory