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Cap1 Gene Detail
Summary
  • Symbol
    Cap1
  • Name
    CAP, adenylate cyclase-associated protein 1 (yeast)
  • Feature Type
    protein coding gene
  • IDs
    MGI:88262
    NCBI Gene: 12331
  • Gene Overview
    MyGene.info: CAP1
Location & Maps
more
  • Sequence Map
    Chr4:122859047-122886056 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27010 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 57.27 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CAP1, adenylate cyclase associated protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CAP1, adenylate cyclase associated protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAP, CAP1-PEN
  • Links
    NCBI Gene ID: 10487
    neXtProt AC: NX_Q01518

  • Chr Location
    1p34.2; chr1:40040240-40072649 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    2
  • Gene trapped
    12
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    4 involving Cap1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008872 VEGA Gene Model | MGI Sequence Detail 27010 C57BL/6J ±  kb
transcript OTTMUST00000020185 VEGA | MGI Sequence Detail 2737 Not Applicable  
polypeptide OTTMUSP00000009255 VEGA | MGI Sequence Detail 474 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    159 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000005006 adenylyl cyclase-associated protein 1
  • InterPro Domains
    IPR001837 Adenylate cyclase-associated CAP
    IPR013912 Adenylate cyclase-associated CAP, C-terminal
    IPR013992 Adenylate cyclase-associated CAP, N-terminal
    IPR028415 Adenylyl cyclase-associated protein CAP1
    IPR028417 CAP, conserved site, C-terminal
    IPR018106 CAP, conserved site, N-terminal
    IPR006599 CARP motif
    IPR017901 C-CAP/cofactor C-like domain
    IPR016098 Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal
Molecular
Reagents
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  • All nucleic 162
    cDNA 162

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1749
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:14028 Vojtek AB, et al., Identification and characterization of a cDNA encoding mouse CAP: a homolog of the yeast adenylyl cyclase associated protein. J Cell Sci. 1993 Jul;105(Pt 3):777-85
  • Latest
    J:218806 Jansen S, et al., Structure and mechanism of mouse cyclase-associated protein (CAP1) in regulating actin dynamics. J Biol Chem. 2014 Oct 31;289(44):30732-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory