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Canx Gene Detail
Summary
  • Symbol
    Canx
  • Name
    calnexin
  • Synonyms
    1110069N15Rik, CNX
  • Feature Type
    protein coding gene
  • IDs
    MGI:88261
    NCBI Gene: 12330
  • Gene Overview
    MyGene.info: CANX
Location & Maps
more
  • Sequence Map
    Chr11:50294467-50325673 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31207 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 30.46 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CANX, calnexin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CANX, calnexin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CNX, IP90, P90
  • Links
    NCBI Gene ID: 821
    neXtProt AC: NX_P27824

  • Chr Location
    5q35; chr5:179678646-179731641 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1324
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CANX
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 1 genetic background
    4 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    71
  • Chemically induced (other)
    1
  • Gene trapped
    64
  • Targeted
    6
  • Genomic Mutations
    1 involving Canx
  • Incidental Mutations
    APF
Homozygotes for a targeted null mutation exhibit motor defects, loss of large myelinated nerve fibers, small size, and very high mortality between birth and 4 weeks of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005582 VEGA Gene Model | MGI Sequence Detail 31207 C57BL/6J ±  kb
transcript OTTMUST00000012410 VEGA | MGI Sequence Detail 3779 Not Applicable  
polypeptide OTTMUSP00000005744 VEGA | MGI Sequence Detail 591 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    82 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005005 calnexin
  • InterPro Domains
    IPR001580 Calreticulin/calnexin
    IPR018124 Calreticulin/calnexin, conserved site
    IPR009033 Calreticulin/calnexin, P domain
    IPR013320 Concanavalin A-like lectin/glucanase domain
Molecular
Reagents
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  • All nucleic 428
    cDNA 427
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-1748, MGI:1099814, MGI:1913469, MGI:2144336
References
more
  • Summaries
    All 107
    Developmental Gene Expression 21
    Gene Ontology 27
    Phenotypes 16
  • Earliest
    J:16706 Rajagopalan S, et al., Retention of unassembled components of integral membrane proteins by calnexin. Science. 1994 Jan 21;263(5145):387-90
  • Latest
    J:232424 Prior KK, et al., The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein. J Biol Chem. 2016 Mar 25;291(13):7045-59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory