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Camk2g Gene Detail
Summary
  • Symbol
    Camk2g
  • Name
    calcium/calmodulin-dependent protein kinase II gamma
  • Synonyms
    5930429P18Rik, Ca2+/calmodulin-dependent protein kinase II, Camkg, CaMK II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88259
    NCBI Gene: 12325
  • Gene Overview
    MyGene.info: CAMK2G
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:20734875-20794088 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59214 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CAMK2G, calcium/calmodulin dependent protein kinase II gamma
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAMK2G, calcium/calmodulin dependent protein kinase II gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAMK, CAMKG, CAMK-II
  • Links
    NCBI Gene ID: 818
    neXtProt AC: NX_Q13555
    UniProt: Q13555

  • Chr Location
    10q22.2; chr10:73812501-73874591 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit female infertility and decreased sensitivity of macrophages to ER stress-induced apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021820 Ensembl Gene Model | MGI Sequence Detail 59214 C57BL/6J ±  kb
    transcript ENSMUST00000226630 Ensembl | MGI Sequence Detail 1937 Not Applicable  
    polypeptide ENSMUSP00000154158 Ensembl | MGI Sequence Detail 565 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      126 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 17
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1746, MGI:2442091
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 12
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:16757 Li X, et al., Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14. Cytogenet Cell Genet. 1994;66(2):113-6
    • Latest
      J:261803 Ghorpade DS, et al., Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. Nature. 2018 Mar 29;555(7698):673-677

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory