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Camk2g Gene Detail
Summary
  • Symbol
    Camk2g
  • Name
    calcium/calmodulin-dependent protein kinase II gamma
  • Synonyms
    5930429P18Rik, Ca2+/calmodulin-dependent protein kinase II, Camkg, CaMK II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88259
    NCBI Gene: 12325
  • Gene Overview
    MyGene.info: CAMK2G
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20734875-20794088 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88259
protein coding gene Chr14:20734873-20794129 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021047
protein coding gene Chr14:13503494-13570924 (-)
A/J MGP_AJ_G0020996
protein coding gene Chr14:13191070-13250389 (-)
AKR/J MGP_AKRJ_G0020973
protein coding gene Chr14:13717601-13776661 (-)
BALB/cJ MGP_BALBcJ_G0020999
protein coding gene Chr14:13296257-13359466 (-)
C3H/HeJ MGP_C3HHeJ_G0020783
protein coding gene Chr14:13656103-13716932 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021432
protein coding gene Chr14:14002623-14062364 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019000
protein coding gene Chr14:13507589-13567066 (-)
CAST/EiJ MGP_CASTEiJ_G0020307
protein coding gene Chr14:13420879-13484262 (-)
CBA/J MGP_CBAJ_G0020749
protein coding gene Chr14:14714157-14775238 (-)
DBA/2J MGP_DBA2J_G0020872
protein coding gene Chr14:13015474-13076104 (-)
FVB/NJ MGP_FVBNJ_G0020855
protein coding gene Chr14:12908566-12972540 (-)
LP/J MGP_LPJ_G0020948
protein coding gene Chr14:13729333-13791073 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020881
protein coding gene Chr14:14490052-14549779 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021465
protein coding gene Chr14:13508580-13584430 (-)
PWK/PhJ MGP_PWKPhJ_G0020056
protein coding gene Chr14:12585960-12646016 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019878
protein coding gene Chr14:13303171-13362293 (-)
WSB/EiJ MGP_WSBEiJ_G0020363
protein coding gene Chr14:13491097-13555447 (-)



Homology
more
  • Human Ortholog
    CAMK2G, calcium/calmodulin dependent protein kinase II gamma
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAMK2G, calcium/calmodulin dependent protein kinase II gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAMK, CAMKG, CAMK-II
  • Links
    NCBI Gene ID: 818
    neXtProt AC: NX_Q13555
    UniProt: Q13555

  • Chr Location
    10q22.2; chr10:73812501-73874591 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit female infertility and decreased sensitivity of macrophages to ER stress-induced apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021820 Ensembl Gene Model | MGI Sequence Detail 59214 C57BL/6J ±  kb
    transcript ENSMUST00000226630 Ensembl | MGI Sequence Detail 1937 Not Applicable  
    polypeptide ENSMUSP00000154158 Ensembl | MGI Sequence Detail 565 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000003202 calcium/calmodulin-dependent protein kinase type II subunit gamma
    • EC
    • InterPro Domains
      IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
      IPR039071 Calcium/calmodulin-dependent protein kinase type II
      IPR032710 NTF2-like domain superfamily
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 17
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1746, MGI:2442091
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 12
      Gene Ontology 9
      Phenotypes 21
    • Earliest
      J:16757 Li X, et al., Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14. Cytogenet Cell Genet. 1994;66(2):113-6
    • Latest
      J:264585 Wang Y, et al., Prostaglandin F2alpha Facilitates Hepatic Glucose Production Through CaMKIIgamma/p38/FOXO1 Signaling Pathway in Fasting and Obesity. Diabetes. 2018 Sep;67(9):1748-1760

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory