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Camk2g Gene Detail
Summary
  • Symbol
    Camk2g
  • Name
    calcium/calmodulin-dependent protein kinase II gamma
  • Synonyms
    5930429P18Rik, Ca2+/calmodulin-dependent protein kinase II, Camkg, CaMK II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88259
    NCBI Gene: 12325
  • Gene Overview
    MyGene.info: CAMK2G
Location & Maps
more
  • Sequence Map
    Chr14:20734875-20794088 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59214 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CAMK2G, calcium/calmodulin dependent protein kinase II gamma
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAMK2G, calcium/calmodulin dependent protein kinase II gamma
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAMK, CAMKG, CAMK-II
  • Links
    NCBI Gene ID: 818
    neXtProt AC: NX_Q13555

  • Chr Location
    10q22; chr10:73812501-73874591 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Targeted
    6
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit female infertility and decreased sensitivity of macrophages to ER stress-induced apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021820 Ensembl Gene Model | MGI Sequence Detail 59214 C57BL/6J ±  kb
transcript ENSMUST00000071816 Ensembl | MGI Sequence Detail 3703 Not Applicable  
polypeptide ENSMUSP00000071720 Ensembl | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    126 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003202 calcium/calmodulin-dependent protein kinase type II subunit gamma
  • EC
  • InterPro Domains
    IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
    IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
    IPR032710 NTF2-like domain
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
less
  • All nucleic 19
    Genomic 1
    cDNA 16
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1746, MGI:2442091
References
more
  • Summaries
    All 56
    Developmental Gene Expression 12
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:16757 Li X, et al., Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14. Cytogenet Cell Genet. 1994;66(2):113-6
  • Latest
    J:223139 Ye J, et al., hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3020-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory