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Camk4 Gene Detail
Summary
  • Symbol
    Camk4
  • Name
    calcium/calmodulin-dependent protein kinase IV
  • Synonyms
    A430110E23Rik, Ca2+/calmodulin-dependent protein kinase type IV/Gr, CaMKIV, CaMKIV/Gr, D18Bwg0362e
  • Feature Type
    protein coding gene
  • IDs
    MGI:88258
    NCBI Gene: 12326
  • Gene Overview
    MyGene.info: CAMK4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:32939041-33195767 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      256727 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 18.15 cM
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    CAMK4, calcium/calmodulin dependent protein kinase IV
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAMK4, calcium/calmodulin dependent protein kinase IV
    Orthology source: HomoloGene, HGNC
  • Synonyms
    caMK, CaMK-GR, CaMK IV
  • Links
    NCBI Gene ID: 814
    neXtProt AC: NX_Q16566
    UniProt: Q16566

  • Chr Location
    5q22.1; chr5:111223653-111498503 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 5 alleles in 5 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for different targeted mutations show variable phenotypes, including reduced viability, male and/or female sterility, and mild to severe neurological and spatial memory disorders.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038128 Ensembl Gene Model | MGI Sequence Detail 256727 C57BL/6J ±  kb
    transcript ENSMUST00000042868 Ensembl | MGI Sequence Detail 12331 Not Applicable  
    polypeptide ENSMUSP00000046539 Ensembl | MGI Sequence Detail 469 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1736 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
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    • All nucleic 21
      Genomic 2
      cDNA 17
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1745, MGD-MRK-33961, MGI:106269, MGI:2147260, MGI:3026992
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 28
    • Earliest
      J:32614 Sikela JM, et al., Screening an expression library with a ligand probe: isolation and sequence of a cDNA corresponding to a brain calmodulin-binding protein. Proc Natl Acad Sci U S A. 1987 May;84(9):3038-42
    • Latest
      J:239523 Chen CM, et al., Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E619-E628

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory