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Anxa6
Gene Detail
Symbol

Name
ID
Anxa6
annexin A6
MGI:88255
Synonyms
Annexin VI, Anx6, AnxVI, Cabm, Camb
Feature Type
protein coding gene
Genetic Map
Chromosome 11
32.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr11:54979108-55033445 bp, - strand
From VEGA annotation of GRCm38

  54338 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55558  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ANXA6
Protein SuperFamily: annexin VI
Gene Tree: Anxa6

Human
homologs
ANXA6, annexin A6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 309
neXtProt AC: NX_P08133

Human Synonyms: ANX6, CBP68

Human Chr (Location): 5q33.1; chr5:151100706-151157882 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(31) Targeted(6) Transgenic(1)
Genomic Mutations involving Anxa6 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele have normal immunological development but exhibit altered cardiomyocyte mechanics and intracellular calcium signaling.
 
Interactions
Anxa6 interacts with 64 markers (Mir26a-1, Mir26a-2, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process calcium ion transport, ion transmembrane transport, ...
Component apical plasma membrane, cytoplasm, ...
Function calcium-dependent phospholipid binding, calcium-dependent protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(284)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ANXA6 ; Xenbase anxa6 ; ZFIN anxa6    NEW 
Molecular
reagents
All nucleic(288) Genomic(1) cDNA(287)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000006325 (Evidence)
Ensembl Gene Model ENSMUSG00000018340 (Evidence)
Entrez Gene 11749 (Evidence)
UniGene 265347
DFCI TC1573117, TC1585077, TC1598026, TC1766609
DoTS DT.101139178, DT.101392554, DT.101392560, DT.110502308, DT.55193012, DT.87072576, DT.91588093, DT.94411864
NIA Mouse Gene Index U032785
Consensus CDS Project CCDS24705.1, CCDS48799.1
International Mouse Phenotyping Consortium Status Anxa6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006325 VEGA Gene Model | MGI Sequence Detail 54338 C57BL/6J ±  kb
transcript OTTMUST00000014362 VEGA | MGI Sequence Detail 2489 Not Applicable 
polypeptide OTTMUSP00000006658 VEGA | MGI Sequence Detail 673 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(4) UniProt(8)
Polymorphisms
RFLP(1) : SNPs within 2kb(602 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001464 Annexin
InterPro IPR018502 Annexin repeat
InterPro IPR018252 Annexin repeat, conserved site
InterPro IPR002393 Annexin, type VI
Protein Ontology PR:000004079 annexin A6
References
(Earliest) J:14450 Moss SE, et al., Molecular cloning of murine p68, a Ca2+-binding protein of the lipocortin family. Eur J Biochem. 1988 Oct 15;177(1):21-7
(Latest) J:213432 Burns TA, et al., Imbalanced expression of Vcan mRNA splice form proteins alters heart morphology and cellular protein profiles. PLoS One. 2014;9(2):e89133
All references(57)
Other
accession IDs
MGD-MRK-1719, MGD-MRK-1742, MGI:2144494

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory