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S100a8
Gene Detail
 Symbol
Name
ID
S100a8
S100 calcium binding protein A8 (calgranulin A)
MGI:88244
Synonyms 60B8Ag, B8Ag, Caga, CFAg, CP-10, MRP8, p8
Feature Type protein coding gene
Genetic Map
Chromosome 3
39.90 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:90669071-90670034 bp, + strand
From NCBI annotation of GRCm38

  964 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2225  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: S-100 protein
Gene Tree: S100a8

Human
homologs
Human Homolog S100A8, S100 calcium binding protein A8
NCBI Gene ID 6279
neXtProt AC  NX_P05109
Human Synonyms  60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8
Human Chr (Location)  1q21; chr1:153390032-153391188 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous disruption of this gene results in complete embryonic lethality. The exact timing of lethality varies between alleles.
 
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component cytoplasm, cytoskeleton, ...
Function antioxidant activity, arachidonic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (3)    Tissues (3)   
Theiler Stages: 19, 21, 28
Assay TypeResults
RT-PCR 3
cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(22) Genomic(3) cDNA(18) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000056054 (Evidence)
Entrez Gene20201 (Evidence)
UniGene21567
DFCITC1580152
DoTSDT.530481
NIA Mouse Gene IndexU073492
Consensus CDS ProjectCCDS38507.1
International Mouse Knockout Project StatusS100a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20201 NCBI Gene Model | MGI Sequence Detail 964 C57BL/6J ±  kb
transcript NM_013650 RefSeq | MGI Sequence Detail 392 C57BL/6 
polypeptide P27005 UniProt | EBI | MGI Sequence Detail 89 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
InterPro IPR001751 S100/Calbindin-D9k, conserved site
Protein Ontology PR:000014417 protein S100-A8
Graphical View of Protein Domain Structure
References (Earliest) J:1255 Lagasse E, et al., Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Blood. 1992 Apr 15;79(8):1907-15
(Latest) J:199826 Kehl-Fie TE, et al., MntABC and MntH Contribute to Systemic Staphylococcus aureus Infection by Competing with Calprotectin for Nutrient Manganese. Infect Immun. 2013 Sep;81(9):3395-405
All references(54)
Other
accession IDs
MGD-MRK-1725, MGI:2139672

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory