S100a8
Gene Detail

Symbol Name ID

S100a8 S100 calcium binding protein A8 (calgranulin A) MGI:88244

Synonyms

60B8Ag, B8Ag, Caga, CFAg, CP-10, MRP8, p8

Feature Type

protein coding gene

Genetic Map

Chromosome 3

39.90 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr3:90669071-90670034 bp, + strand From NCBI annotation of GRCm38   964 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2225  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: S-100 protein
Gene Tree: S100a8

Human homologs

Human Homolog		S100A8, S100 calcium binding protein A8
NCBI Gene ID		6279
neXtProt AC		NX_P05109
Human Synonyms		60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8
Human Chr (Location)		1q21; chr1:153362508-153363664 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous disruption of this gene results in complete embryonic lethality. The exact timing of lethality varies between alleles.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	cytoplasm, cytoskeleton, ...
Function	antioxidant activity, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (3)    Tissues (3)   
Theiler Stages: 19, 21, 28

Assay Type	Results
RT-PCR	3

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(3) cDNA(18) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000056054 (Evidence)
Entrez Gene	20201 (Evidence)
UniGene	21567
DFCI	TC1580152
DoTS	DT.530481
NIA Mouse Gene Index	U073492
Consensus CDS Project	CCDS38507.1
International Mouse Knockout Project Status	S100a8

Sequences

Length	Strain/Species
genomic	20201	NCBI Gene Model | MGI Sequence Detail	964	C57BL/6J
transcript	NM_013650	RefSeq | MGI Sequence Detail	392	C57BL/6
polypeptide	P27005	UniProt | EBI | MGI Sequence Detail	89	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(26 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018248	EF-hand
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR018249	EF-HAND 2
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain
InterPro	IPR001751	S100/Calbindin-D9k, conserved site
Protein Ontology	PR:000014417	protein S100-A8

Graphical View of Protein Domain Structure

References

(Earliest) J:1255 Lagasse E, et al., Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Blood. 1992 Apr 15;79(8):1907-15
(Latest) J:193123 Petersen B, et al., The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis. EMBO J. 2013 Jan 9;32(1):100-11
All references(51)

Other accession IDs

MGD-MRK-1725, MGI:2139672