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C7
Gene Detail
 Symbol
Name
ID
C7
complement component 7
MGI:88235
Synonyms LOC383055
Feature Type protein coding gene
Genetic Map
Chromosome 15
1.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:4988762-5063773 bp, - strand
From NCBI annotation of GRCm38

  75012 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: C7

Human
homologs
Human Homolog C7, complement component 7
NCBI Gene ID 730
neXtProt AC  NX_P10643
Human Chr (Location)  5p13; chr5:40909497-40982939 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human C7
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(11)
Incidental mutations (data from Mutagenetix , APF )
Interactions
C7 interacts with 26 markers (Mir23a, Mir23b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (2 annotations)
Process cellular sodium ion homeostasis
Component extracellular vesicular exosome
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (2)   
Theiler Stages: 26, 28
Assay TypeResults
Northern blot 6
cDNA source data(1)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(2) cDNA(1) Other(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000079105 (Evidence)
Entrez Gene109828 (Evidence)
DFCITC1631194
DoTSDT.91333483
NIA Mouse Gene IndexU035976
Consensus CDS ProjectCCDS56974.1
International Mouse Knockout Project StatusC7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 109828 NCBI Gene Model | MGI Sequence Detail 75012 C57BL/6J ±  kb
transcript NM_001243837 RefSeq | MGI Sequence Detail 2709 C57BL/6 
polypeptide NP_001230766 RefSeq | MGI Sequence Detail 845 C57BL/6 

For the selected sequences
All sequences(11) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(293 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003884 Factor I / membrane attack complex
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR001862 Membrane attack complex component/perforin/complement C9
InterPro IPR020863 Membrane attack complex component/perforin domain, conserved site
InterPro IPR020864 Membrane attack complex component/perforin (MACPF) domain
InterPro IPR000436 Sushi/SCR/CCP
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000004907 complement component C7
References (Earliest) J:7901 Orren A, et al., Close linkage between mouse genes determining the two forms of complement component C6 and component C7, and cis action of a C6 regulatory gene. Immunogenetics. 1985;21(6):591-9
(Latest) J:210789 Welsh KJ, et al., Complement factor C7 contributes to lung immunopathology caused by Mycobacterium tuberculosis. Clin Dev Immunol. 2012;2012:429675
All references(23)
Other
accession IDs
MGD-MRK-1713, MGI:2686084

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory