About   Help   FAQ
C7 Gene Detail
Summary
  • Symbol
    C7
  • Name
    complement component 7
  • Synonyms
    LOC383055
  • Feature Type
    protein coding gene
  • IDs
    MGI:88235
    NCBI Gene: 109828
Location & Maps
more
  • Sequence Map
    Chr15:4988762-5063773 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      75012 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 1.98 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    C7, complement component 7
  • Vertebrate Orthologs
    11
  • Human Ortholog
    C7, complement component 7
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 730
    neXtProt AC: NX_P10643

  • Chr Location
    5p13; chr5:40909473-41016004 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 489
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: C7
  • Gene Tree
    C7
Human Diseases
more
  • Diseases
    1 with human C7 associations

Human Disease Mouse Models
       Complement Component 7 Deficiency; C7D   OMIM: 610102
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 109828 NCBI Gene Model | MGI Sequence Detail 75012 C57BL/6J ±  kb
transcript NM_001243837 RefSeq | MGI Sequence Detail 2709 C57BL/6  
polypeptide NP_001230766 RefSeq | MGI Sequence Detail 845 C57BL/6  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    293 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR003884 Factor I / membrane attack complex
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR001862 Membrane attack complex component/perforin/complement C9
    IPR020863 Membrane attack complex component/perforin domain, conserved site
    IPR020864 Membrane attack complex component/perforin (MACPF) domain
    IPR000436 Sushi/SCR/CCP domain
    IPR000884 Thrombospondin type-1 (TSP1) repeat
Molecular
Reagents
less
  • All nucleic 2
    cDNA 1
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-1713, MGI:2686084
References
more
  • Summaries
    All 17
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 1
  • Earliest
    J:7901 Orren A, et al., Close linkage between mouse genes determining the two forms of complement component C6 and component C7, and cis action of a C6 regulatory gene. Immunogenetics. 1985;21(6):591-9
  • Latest
    J:210789 Welsh KJ, et al., Complement factor C7 contributes to lung immunopathology caused by Mycobacterium tuberculosis. Clin Dev Immunol. 2012;2012:429675

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory