About   Help   FAQ
C6 Gene Detail
Summary
  • Symbol
    C6
  • Name
    complement component 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:88233
    NCBI Gene: 12274
  • Gene Overview
    MyGene.info: C6
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:4727067-4804045 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 1.97 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    341 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88233
protein coding gene Chr15:4727067-4814967 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021687
protein coding gene Chr15:1603668-1684158 (+)
A/J MGP_AJ_G0021647
protein coding gene Chr15:1627745-1712167 (+)
AKR/J MGP_AKRJ_G0021625
protein coding gene Chr15:1619445-1704603 (+)
BALB/cJ MGP_BALBcJ_G0021654
protein coding gene Chr15:1565762-1649640 (+)
C3H/HeJ MGP_C3HHeJ_G0021430
protein coding gene Chr15:1649850-1735650 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022093
protein coding gene Chr15:1699238-1774030 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019631
protein coding gene Chr15:1408794-1483952 (+)
CAST/EiJ MGP_CASTEiJ_G0020947
protein coding gene Chr15:1626227-1711847 (+)
CBA/J MGP_CBAJ_G0021399
protein coding gene Chr15:1735509-1816355 (+)
DBA/2J MGP_DBA2J_G0021523
protein coding gene Chr15:1576339-1660294 (+)
FVB/NJ MGP_FVBNJ_G0021501
protein coding gene Chr15:1528430-1609335 (+)
LP/J MGP_LPJ_G0021590
protein coding gene Chr15:1552340-1633583 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021527
protein coding gene Chr15:1847154-1952328 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022116
protein coding gene Chr15:1624306-1704901 (+)
PWK/PhJ MGP_PWKPhJ_G0020690
protein coding gene Chr15:1589402-1675328 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020528
protein coding gene Chr15:1624607-1692864 (+)
WSB/EiJ MGP_WSBEiJ_G0021002
protein coding gene Chr15:1580796-1663411 (+)



Homology
more
  • Human Ortholog
    C6, complement C6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    C6, complement C6
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 729
    neXtProt AC: NX_P13671
    UniProt: P13671

  • Chr Location
    5p13.1; chr5:41142116-41261486 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 47
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: C6
  • Gene Tree
    C6
Human Diseases
more
  • Diseases
    1 with human C6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation exhibit decreased susceptibility to ischemia reperfusion-induced renal injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12274 NCBI Gene Model | MGI Sequence Detail 76979 C57BL/6J ±  kb
transcript NM_016704 RefSeq | MGI Sequence Detail 2863 C57BL/6  
polypeptide NP_057913 RefSeq | MGI Sequence Detail 769 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR037563 Complement component C6
    IPR003884 Factor I / membrane attack complex
    IPR002350 Kazal domain
    IPR036055 LDL receptor-like superfamily
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR001862 Membrane attack complex component/perforin/complement C9
    IPR020863 Membrane attack complex component/perforin domain, conserved site
    IPR020864 Membrane attack complex component/perforin (MACPF) domain
    IPR000436 Sushi/SCR/CCP domain
    IPR035976 Sushi/SCR/CCP superfamily
    IPR000884 Thrombospondin type-1 (TSP1) repeat
    IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Molecular
Reagents
less
  • All nucleic 28
    cDNA 27
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1711, MGI:2146192
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:7685 Hayakawa JI, et al., Genetic polymorphism of the sixth component of complement (C6) in mice. Immunogenetics. 1984;20(6):633-8
  • Latest
    J:190597 Elvington A, et al., The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012 Nov 1;189(9):4640-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory