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C6
Gene Detail
 Symbol
Name
ID
C6
complement component 6
MGI:88233
Feature Type protein coding gene
Genetic Map
Chromosome 15
1.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:4727175-4815456 bp, + strand
From VEGA annotation of GRCm38

  88282 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Gene Tree: C6

Human
homologs
Human Homolog C6, complement component 6
NCBI Gene ID 729
neXtProt AC  NX_P13671
Human Chr (Location)  5p13; chr5:41142146-41261486 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human C6
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous mutation exhibit decreased susceptibility to ischemia reperfusion-induced renal injury.
 
Interactions
C6 interacts with 105 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process in utero embryonic development, positive regulation of activation of membrane attack complex, ...
Component extracellular space, extracellular vesicular exosome
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 11
Assay TypeResults
RT-PCR 1
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000032527 (Evidence)
Ensembl Gene ModelENSMUSG00000022181 (Evidence)
Entrez Gene12274 (Evidence)
UniGene20247
DFCITC1584239, TC1617474
DoTSDT.488119
NIA Mouse Gene IndexU016016
Consensus CDS ProjectCCDS37025.1
International Mouse Knockout Project StatusC6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032527 VEGA Gene Model | MGI Sequence Detail 88282 C57BL/6J ±  kb
transcript OTTMUST00000083365 VEGA | MGI Sequence Detail 3404 Not Applicable 
polypeptide OTTMUSP00000044780 VEGA | MGI Sequence Detail 931 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(417 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002350 Kazal domain
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR001862 Membrane attack complex component/perforin/complement C9
InterPro IPR020863 Membrane attack complex component/perforin domain, conserved site
InterPro IPR020864 Membrane attack complex component/perforin (MACPF) domain
InterPro IPR000436 Sushi/SCR/CCP
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000004905 complement component C6
References (Earliest) J:7685 Hayakawa JI, et al., Genetic polymorphism of the sixth component of complement (C6) in mice. Immunogenetics. 1984;20(6):633-8
(Latest) J:190597 Elvington A, et al., The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012 Nov 1;189(9):4640-7
All references(41)
Other
accession IDs
MGD-MRK-1711, MGI:2146192

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory