C6
Gene Detail

Symbol Name ID

C6 complement component 6 MGI:88233

Feature Type

protein coding gene

Genetic Map

Chromosome 15

1.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr15:4727175-4815456 bp, + strand From VEGA annotation of GRCm38   88282 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:47  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: C6

Human homologs

Human Homolog		C6, complement component 6
NCBI Gene ID		729
neXtProt AC		NX_P13671
Human Chr (Location)		5p13; chr5:41142336-41261540 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human C6

Alleles and phenotypes

All alleles(4) : Targeted(3) Spontaneous(1)
 

Mice homozygous for a spontaneous mutation exhibit decreased susceptibility to ischemia reperfusion-induced renal injury.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, induction of apoptosis, ...
Component	extracellular space

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 11

Assay Type	Results
RT-PCR	1

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000032527 (Evidence)
Ensembl Gene Model	ENSMUSG00000022181 (Evidence)
Entrez Gene	12274 (Evidence)
UniGene	20247
DFCI	TC1584239, TC1617474
DoTS	DT.488119
NIA Mouse Gene Index	U016016
Consensus CDS Project	CCDS37025.1
International Mouse Knockout Project Status	C6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032527	VEGA Gene Model | MGI Sequence Detail	88282	C57BL/6J
transcript	OTTMUST00000083365	VEGA | MGI Sequence Detail	3404	Not Applicable
polypeptide	OTTMUSP00000044780	VEGA | MGI Sequence Detail	931	Not Applicable

All sequences(40) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(240 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR002350	Kazal domain
InterPro	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR001862	Membrane attack complex component/perforin/complement C9
InterPro	IPR020863	Membrane attack complex component/perforin domain, conserved site
InterPro	IPR020864	Membrane attack complex component/perforin (MACPF) domain
InterPro	IPR000436	Sushi/SCR/CCP
InterPro	IPR000884	Thrombospondin, type 1 repeat
Protein Ontology	PR:000004905	complement component C6

References

(Earliest) J:7685 Hayakawa JI, et al., Genetic polymorphism of the sixth component of complement (C6) in mice. Immunogenetics. 1984;20(6):633-8
(Latest) J:190597 Elvington A, et al., The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012 Nov 1;189(9):4640-7
All references(40)

Other accession IDs

MGD-MRK-1711, MGI:2146192