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C6 Gene Detail
Summary
  • Symbol
    C6
  • Name
    complement component 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:88233
    NCBI Gene: 12274
  • Gene Overview
    MyGene.info: C6
Location & Maps
more
  • Sequence Map
    Chr15:4727175-4815456 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      88282 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 1.97 cM
  • Mapping Data
    6 experiments
Homology
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  • Human Ortholog
    C6, complement C6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    C6, complement C6
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 729
    neXtProt AC: NX_P13671

  • Chr Location
    5p13; chr5:41142146-41261486 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 47
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;2 frog, western clawed
  • HCOP
    human homology predictions: C6
  • Gene Tree
    C6
Human Diseases
more
  • Diseases
    1 with human C6 associations

Human Disease Mouse Models
       Complement Component 6 Deficiency; C6D   OMIM: 612446
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Spontaneous
    1
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a spontaneous mutation exhibit decreased susceptibility to ischemia reperfusion-induced renal injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032527 VEGA Gene Model | MGI Sequence Detail 88282 C57BL/6J ±  kb
transcript OTTMUST00000083365 VEGA | MGI Sequence Detail 3404 Not Applicable  
polypeptide OTTMUSP00000044780 VEGA | MGI Sequence Detail 931 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    401 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR003884 Factor I / membrane attack complex
    IPR002350 Kazal domain
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR001862 Membrane attack complex component/perforin/complement C9
    IPR020863 Membrane attack complex component/perforin domain, conserved site
    IPR020864 Membrane attack complex component/perforin (MACPF) domain
    IPR000436 Sushi/SCR/CCP domain
    IPR000884 Thrombospondin type-1 (TSP1) repeat
Molecular
Reagents
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  • All nucleic 27
    cDNA 26
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1711, MGI:2146192
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:7685 Hayakawa JI, et al., Genetic polymorphism of the sixth component of complement (C6) in mice. Immunogenetics. 1984;20(6):633-8
  • Latest
    J:190597 Elvington A, et al., The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012 Nov 1;189(9):4640-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory