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C5ar1 Gene Detail
Summary
  • Symbol
    C5ar1
  • Name
    complement component 5a receptor 1
  • Synonyms
    C5aR, C5r1, Cd88, D7Msu1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88232
    NCBI Gene: 12273
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:15980668-15993465 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 8.77 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    338 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88232
 protein coding gene Chr7:15980668-15993465 (-)
129S1/SvImJ ENSMUSG00200038323
 protein coding gene Chr7:9357532-9370453 (-)
A/J ENSMUSG00195049523
 protein coding gene Chr7:9818912-9831639 (-)
AKR/J ENSMUSG00220026498
 protein coding gene Chr7:8111179-8124099 (-)
BALB/cJ ENSMUSG00180049090
 protein coding gene Chr7:9734716-9747442 (-)
C3H/HeJ ENSMUSG00175039428
 protein coding gene Chr7:10222227-10234946 (-)
C57BL/6NJ ENSMUSG00215035234
 protein coding gene Chr7:9479347-9492142 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029228
 protein coding gene Chr7:15269356-15281551 (-)
CAST/EiJ ENSTCUG00005048125
 protein coding gene Chr7:10224548-10237148 (-)
CBA/J ENSMUSG00210035601
 protein coding gene Chr7:9449623-9462546 (-)
DBA/2J ENSMUSG00185052369
 protein coding gene Chr7:12964076-12976793 (-)
FVB/NJ ENSMUSG00205026323
 protein coding gene Chr7:9854508-9867410 (-)
JF1/MsJ ENSUMUG00000013638
 protein coding gene Chr7:16235317-16247873 (-)
LP/J ENSMUSG00230043009
 protein coding gene Chr7:17182451-17194784 (-)
NOD/ShiLtJ ENSMUSG00190035101
 protein coding gene Chr7:6281807-6294504 (-)
NZO/HlLtJ ENSMUSG00225052034
 protein coding gene Chr7:14416304-14429217 (-)
PWK/PhJ ENSLUMG00010049848
 protein coding gene Chr7:12540330-12552811 (-)
SPRET/EiJ ENSMSPG00010040950
 protein coding gene Chr7:9000500-9012275 (-)
WSB/EiJ ENSIUOG00005051284
 protein coding gene Chr7:16243062-16255768 (+)



Homology
more
  • Human Ortholog
    C5AR1, complement C5a receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C5AR1, complement C5a receptor 1
  • Synonyms
    C5A, C5AR, C5R1, CD88
  • Links
    NCBI Gene ID: 728
    UniProt: P21730

  • Chr Location
    19q13.32; chr19:47290023-47322066 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 6 genetic backgrounds
    15 phenotypes from multigenic genotypes
    204 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutants have impaired C5 responses that can show increased or decreased acute inflammation under different circumstances, and thus affect severity of disease or infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    641
  • Tissues
    29
  • cDNA Data
    10
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12273 NCBI Gene Model | MGI Sequence Detail 12798 C57BL/6J ±  kb
    transcript NM_001173550 RefSeq | MGI Sequence Detail 2540 ZRU/MplStud  
    polypeptide P30993 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 10
      Primer pair 4
      Other 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1710, MGI:2180152
    References
    more
    • Summaries
      All 284
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 204
    • Earliest
      J:2871 Gerard C, et al., Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J Immunol. 1992 Oct 15;149(8):2600-6
    • Latest
      J:391658 Suzuki S, et al., Tumor-Derived Complement C3 Overexpression in STK11-Mutant Lung Adenocarcinoma Drives Tumor Growth and Immune Checkpoint Inhibitor Resistance. Cancer Immunol Res. 2026 Jul 2;14(7):1172-1185
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory