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C5ar1
Gene Detail
Symbol

Name
ID
C5ar1
complement component 5a receptor 1
MGI:88232
Synonyms
C5aR, C5r1, Cd88, D7Msu1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
8.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:16246743-16259540 bp, - strand
From NCBI annotation of GRCm38

  12798 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20413  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: C5AR1
Protein SuperFamily: C5a anaphylatoxin chemotactic receptor
Gene Tree: C5ar1

Human
homologs
C5AR1, complement component 5a receptor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 728
neXtProt AC: NX_P21730

Human Synonyms: C5A, C5AR, C5R1, CD88

Human Chr (Location): 19q13.3-q13.4; chr19:47307745-47322070 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants have impaired C5 responses that can show increased or decreased acute inflammation under different circumstances, and thus affect severity of disease or infection.
 
Interactions
C5ar1 interacts with 152 markers (Mir7b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (29)    Tissues (16)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 22
RT-PCR 4
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase c5ar1    NEW 
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000049130 (Evidence)
Entrez Gene 12273 (Evidence)
UniGene 247623
DFCI TC1599440, TC1664072, TC1725370
DoTS DT.99849838
Consensus CDS Project CCDS20846.1
International Mouse Phenotyping Consortium Status C5ar1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12273 NCBI Gene Model | MGI Sequence Detail 12798 C57BL/6J ±  kb
transcript NM_001173550 RefSeq | MGI Sequence Detail 2540 C57BL/6 
polypeptide P30993 UniProt | EBI | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002234 Anaphylatoxin chemotactic receptor
InterPro IPR001274 C5A-anaphylatoxin receptor
InterPro IPR000826 Formyl peptide receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001173 C5a anaphylatoxin chemotactic receptor 1
Graphical View of Protein Domain Structure
References
(Earliest) J:2871 Gerard C, et al., Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J Immunol. 1992 Oct 15;149(8):2600-6
(Latest) J:221666 Brennan FH, et al., The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury. J Neurosci. 2015 Apr 22;35(16):6517-31
All references(142)
Other
accession IDs
MGD-MRK-1710, MGI:2180152

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory