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C5ar1
Gene Detail
 Symbol
Name
ID
C5ar1
complement component 5a receptor 1
MGI:88232
Synonyms C5aR, C5r1, Cd88, D7Msu1
Feature Type protein coding gene
Genetic Map
Chromosome 7
8.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:16246743-16259540 bp, - strand
From NCBI annotation of GRCm38

  12798 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20413  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: C5a anaphylatoxin chemotactic receptor
Gene Tree: C5ar1

Human
homologs
Human Homolog C5AR1, complement component 5a receptor 1
NCBI Gene ID 728
neXtProt AC  NX_P21730
Human Synonyms  C5A, C5AR, C5R1, CD88
Human Chr (Location)  19q13.3-q13.4; chr19:47309847-47322070 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants have impaired C5 responses that can show increased or decreased acute inflammation under different circumstances, and thus affect severity of disease or infection.
 
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process apoptotic process, cell proliferation in hindbrain, ...
Component apical part of cell, basolateral plasma membrane, ...
Function C5a anaphylatoxin receptor activity, complement component C5a binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(9) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000049130 (Evidence)
Entrez Gene12273 (Evidence)
UniGene247623
DFCITC1599440, TC1664072, TC1725370
DoTSDT.99849838
Consensus CDS ProjectCCDS20846.1
International Mouse Knockout Project StatusC5ar1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12273 NCBI Gene Model | MGI Sequence Detail 12798 C57BL/6J ±  kb
transcript NM_001173550 RefSeq | MGI Sequence Detail 2540 C57BL/6 
polypeptide NP_031603 RefSeq | MGI Sequence Detail 351 Not Specified 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002234 Anaphylatoxin chemotactic receptor
InterPro IPR001274 C5A-anaphylatoxin receptor
InterPro IPR000826 Formyl peptide receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001173 C5a anaphylatoxin chemotactic receptor
References (Earliest) J:2871 Gerard C, et al., Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J Immunol. 1992 Oct 15;149(8):2600-6
(Latest) J:206177 Kim H, et al., Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria. Infect Immun. 2014 Jan;82(1):371-9
All references(133)
Other
accession IDs
MGD-MRK-1710, MGI:2180152

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory