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C5ar1 Gene Detail
Summary
  • Symbol
    C5ar1
  • Name
    complement component 5a receptor 1
  • Synonyms
    C5aR, C5r1, Cd88, D7Msu1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88232
    NCBI Gene: 12273
  • Gene Overview
    MyGene.info: C5AR1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:16246743-16259540 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 8.77 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88232
protein coding gene Chr7:16246743-16259540 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031704
protein coding gene Chr7:13916240-13930319 (-)
A/J MGP_AJ_G0031676
protein coding gene Chr7:13712413-13726383 (-)
AKR/J MGP_AKRJ_G0031601
protein coding gene Chr7:14016157-14032421 (-)
BALB/cJ MGP_BALBcJ_G0031683
protein coding gene Chr7:13808273-13820954 (-)
C3H/HeJ MGP_C3HHeJ_G0031405
protein coding gene Chr7:14192874-14207594 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032149
protein coding gene Chr7:14667910-14681323 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029228
protein coding gene Chr7:15269356-15281551 (-)
CAST/EiJ MGP_CASTEiJ_G0030756
protein coding gene Chr7:10962570-10978013 (-)
CBA/J MGP_CBAJ_G0031364
protein coding gene Chr7:15136887-15152107 (-)
DBA/2J MGP_DBA2J_G0031520
protein coding gene Chr7:13595933-13609281 (-)
FVB/NJ MGP_FVBNJ_G0031476
protein coding gene Chr7:13488637-13503076 (-)
LP/J MGP_LPJ_G0031605
protein coding gene Chr7:14183413-14195689 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031511
protein coding gene Chr7:15104123-15118742 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032178
protein coding gene Chr7:13795488-13809606 (-)
PWK/PhJ MGP_PWKPhJ_G0030480
protein coding gene Chr7:11104457-11124531 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030307
protein coding gene Chr7:8726316-8738072 (-)
WSB/EiJ MGP_WSBEiJ_G0030853
protein coding gene Chr7:13849804-13866863 (-)



Homology
more
  • Human Ortholog
    C5AR1, complement C5a receptor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    C5AR1, complement C5a receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C5A, C5AR, C5R1, CD88
  • Links
    NCBI Gene ID: 728
    neXtProt AC: NX_P21730
    UniProt: P21730

  • Chr Location
    19q13.32; chr19:47309847-47322070 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 5 genetic backgrounds
    117 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous targeted mutants have impaired C5 responses that can show increased or decreased acute inflammation under different circumstances, and thus affect severity of disease or infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12273 NCBI Gene Model | MGI Sequence Detail 12798 C57BL/6J ±  kb
    transcript NM_001173550 RefSeq | MGI Sequence Detail 2540 C57BL/6  
    polypeptide P30993 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 10
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1710, MGI:2180152
    References
    more
    • Summaries
      All 173
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 117
    • Earliest
      J:2871 Gerard C, et al., Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J Immunol. 1992 Oct 15;149(8):2600-6
    • Latest
      J:266018 Medler TR, et al., Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy. Cancer Cell. 2018 Oct 8;34(4):561-578.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory