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C1qc Gene Detail
Summary
  • Symbol
    C1qc
  • Name
    complement component 1, q subcomponent, C chain
  • Synonyms
    C1qg
  • Feature Type
    protein coding gene
  • IDs
    MGI:88225
    NCBI Gene: 12262
Location & Maps
more
  • Sequence Map
    Chr4:136889804-136893065 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3262 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 69.05 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    C1QC, complement C1q C chain
  • Vertebrate Orthologs
    9
  • Human Ortholog
    C1QC, complement C1q C chain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1Q-C, C1QG
  • Links
    NCBI Gene ID: 714
    neXtProt AC: NX_P02747

  • Chr Location
    1p36.11; chr1:22643625-22648110 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human C1QC associations

Human Disease Mouse Models
       C1q Deficiency; C1QD   OMIM: 613652
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Targeted
    1
  • Genomic Mutations
    3 involving C1qc
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009764 VEGA Gene Model | MGI Sequence Detail 3262 C57BL/6J ±  kb
transcript OTTMUST00000022607 VEGA | MGI Sequence Detail 1203 Not Applicable  
polypeptide OTTMUSP00000010320 VEGA | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    85 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004878 complement C1q subcomponent subunit C
  • InterPro Domains
    IPR001073 C1q domain
    IPR008160 Collagen triple helix repeat
    IPR008983 Tumour necrosis factor-like domain
Molecular
Reagents
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  • All nucleic 45
    Genomic 3
    cDNA 42

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1698, MGI:2140252
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:3065 Petry F, et al., Isolation, sequence analysis and characterization of cDNA clones coding for the C chain of mouse C1q. Sequence similarity of complement subcomponent C1q, collagen type VIII and type X and precerebellin. Eur J Biochem. 1992 Oct 1;209(1):129-34
  • Latest
    J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory