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C1qb Gene Detail
Summary
  • Symbol
    C1qb
  • Name
    complement component 1, q subcomponent, beta polypeptide
  • Feature Type
    protein coding gene
  • IDs
    MGI:88224
    NCBI Gene: 12260
Location & Maps
more
  • Sequence Map
    Chr4:136880129-136886187 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6059 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    C1QB, complement component 1, q subcomponent, B chain
  • Vertebrate Orthologs
    7
  • Human Ortholog
    C1QB, complement component 1, q subcomponent, B chain
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 713
    neXtProt AC: NX_P02746

  • Chr Location
    1p36.12; chr1:22653179-22661552 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human C1QB associations

Human Disease Mouse Models
       C1q Deficiency; C1QD   OMIM: 613652
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving C1qb
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009766 VEGA Gene Model | MGI Sequence Detail 6059 C57BL/6J ±  kb
transcript OTTMUST00000022610 VEGA | MGI Sequence Detail 1088 Not Applicable  
polypeptide OTTMUSP00000010322 VEGA | MGI Sequence Detail 253 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    124 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004876 complement C1q subcomponent subunit B
  • InterPro Domains
    IPR001073 C1q domain
    IPR008160 Collagen triple helix repeat
    IPR008983 Tumour necrosis factor-like domain
Molecular
Reagents
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  • All nucleic 125
    Genomic 2
    cDNA 123

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-1697
References
more
  • Summaries
    All 35
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:10130 Petry F, et al., Molecular cloning and characterization of the complementary DNA coding for the B-chain of murine Clq. FEBS Lett. 1989 Nov 20;258(1):89-93
  • Latest
    J:174607 Lu CC, et al., Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci. 2011 Jul 27;31(30):10903-18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory