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C1qb
Gene Detail
Symbol

Name
ID
C1qb
complement component 1, q subcomponent, beta polypeptide
MGI:88224
Feature Type
protein coding gene
Genetic Map
Chromosome 4
69.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:136880129-136886187 bp, - strand
From VEGA annotation of GRCm38

  6059 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:418  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: C1QB
Protein SuperFamily: complement subcomponent C1q chain A
Gene Tree: C1qb

Human
homologs
C1QB, complement component 1, q subcomponent, B chain
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 713
neXtProt AC: NX_P02746

Human Chr (Location): 1p36.12; chr1:22653179-22661552 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human C1QB

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving C1qb (1)
Interactions
C1qb interacts with 26 markers (Mir34b, Mir34c, Mir139, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process complement activation, classical pathway, immune system process, ...
Component blood microparticle, collagen trimer, ...
Function protein homodimerization activity
External Resources: FuncBase
Expression
cDNA source data(122)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN c1qb    NEW 
Molecular
reagents
All nucleic(125) Genomic(2) cDNA(123)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000009766 (Evidence)
Ensembl Gene Model ENSMUSG00000036905 (Evidence)
Entrez Gene 12260 (Evidence)
UniGene 2570
DFCI TC1572610, TC1759693
DoTS DT.97405765
NIA Mouse Gene Index U025672
Consensus CDS Project CCDS18810.1
International Mouse Phenotyping Consortium Status C1qb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009766 VEGA Gene Model | MGI Sequence Detail 6059 C57BL/6J ±  kb
transcript OTTMUST00000022610 VEGA | MGI Sequence Detail 1088 Not Applicable 
polypeptide OTTMUSP00000010322 VEGA | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR001073 Complement C1q protein
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000004876 complement C1q subcomponent subunit B
References
(Earliest) J:10130 Petry F, et al., Molecular cloning and characterization of the complementary DNA coding for the B-chain of murine Clq. FEBS Lett. 1989 Nov 20;258(1):89-93
(Latest) J:174607 Lu CC, et al., Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci. 2011 Jul 27;31(30):10903-18
All references(38)
Other
accession IDs
MGD-MRK-1697

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory