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Tspo Gene Detail
Summary
  • Symbol
    Tspo
  • Name
    translocator protein
  • Synonyms
    Bzrp, PBR, Tspo1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88222
    NCBI Gene: 12257
  • Gene Overview
    MyGene.info: TSPO
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:83563592-83574203 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 39.40 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88222
protein coding gene Chr15:83563573-83574203 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022167
protein coding gene Chr15:84273466-84288799 (+)
A/J MGP_AJ_G0022126
protein coding gene Chr15:81187899-81198531 (+)
AKR/J MGP_AKRJ_G0022101
protein coding gene Chr15:83552212-83562848 (+)
BALB/cJ MGP_BALBcJ_G0022132
protein coding gene Chr15:81330691-81341100 (+)
C3H/HeJ MGP_C3HHeJ_G0021902
protein coding gene Chr15:83508823-83521272 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022577
protein coding gene Chr15:87524575-87536445 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020102
protein coding gene Chr15:77564702-77575412 (+)
CAST/EiJ MGP_CASTEiJ_G0021424
protein coding gene Chr15:84278812-84290869 (+)
CBA/J MGP_CBAJ_G0021869
protein coding gene Chr15:90289882-90303257 (+)
DBA/2J MGP_DBA2J_G0021996
protein coding gene Chr15:80672479-80683502 (+)
FVB/NJ MGP_FVBNJ_G0021975
protein coding gene Chr15:79716941-79728059 (+)
LP/J MGP_LPJ_G0022067
protein coding gene Chr15:84447865-84458443 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021995
protein coding gene Chr15:95189117-95202709 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022592
protein coding gene Chr15:83551725-83566134 (+)
PWK/PhJ MGP_PWKPhJ_G0021165
protein coding gene Chr15:80664650-80676153 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020999
protein coding gene Chr15:83284465-83297024 (+)
WSB/EiJ MGP_WSBEiJ_G0021473
protein coding gene Chr15:84053714-84066121 (+)



Homology
more
  • Human Ortholog
    TSPO, translocator protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TSPO, translocator protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BPBS, BZRP, DBI, IBP, MBR, mDRC, PBR, PBS, pk18, PKBS, PTBR
  • Links
    NCBI Gene ID: 706
    neXtProt AC: NX_P30536
    UniProt: P30536

  • Chr Location
    22q13.2; chr22:43151514-43163242 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 6 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Radiation induced
    2
  • Targeted
    7
  • Genomic Mutations
    3 involving Tspo
  • Find Mice (IMSR)
Mice homozygous for a conditional allele activated in the male reproductive system exhibit normal testicular development, reproduction and testosterone production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041736 Ensembl Gene Model | MGI Sequence Detail 10612 C57BL/6J ±  kb
transcript ENSMUST00000047419 Ensembl | MGI Sequence Detail 837 Not Applicable  
polypeptide ENSMUSP00000037039 Ensembl | MGI Sequence Detail 169 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 182
    cDNA 177
    Primer pair 3
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1694
References
more
  • Summaries
    All 90
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 7
    Phenotypes 37
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:255689 Barron AM, et al., Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male. Biochem J. 2018 Jan 2;475(1):75-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory