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Commd3 Gene Detail
Summary
  • Symbol
    Commd3
  • Name
    COMM domain containing 3
  • Synonyms
    Bup, D2Ertd542e
  • Feature Type
    protein coding gene
  • IDs
    MGI:88218
    NCBI Gene: 12238
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:18677246-18681042 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 12.90 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88218
 protein coding gene Chr2:18677234-18681042 (+)
129S1/SvImJ ENSMUSG00200041701
 protein coding gene Chr2:15631092-15634940 (+)
A/J ENSMUSG00195015994
 protein coding gene Chr2:15709168-15712983 (+)
AKR/J ENSMUSG00220013468
 protein coding gene Chr2:15702160-15706014 (+)
BALB/cJ ENSMUSG00180036160
 protein coding gene Chr2:15752496-15756305 (+)
C3H/HeJ ENSMUSG00175021309
 protein coding gene Chr2:15713681-15717488 (+)
C57BL/6NJ ENSMUSG00215030413
 protein coding gene Chr2:15802822-15806672 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023206
 protein coding gene Chr2:15115159-15119011 (+)
CAST/EiJ ENSTCUG00005004279
 protein coding gene Chr2:15562782-15566643 (+)
CBA/J ENSMUSG00210003543
 protein coding gene Chr2:15751637-15755483 (+)
DBA/2J ENSMUSG00185037607
 protein coding gene Chr2:15651311-15655125 (+)
FVB/NJ ENSMUSG00205011909
 protein coding gene Chr2:15705985-15709835 (+)
JF1/MsJ ENSUMUG00000002982
 protein coding gene Chr2:15628927-15632819 (+)
LP/J ENSMUSG00230015419
 protein coding gene Chr2:17589368-17593218 (+)
NOD/ShiLtJ ENSMUSG00190014428
 protein coding gene Chr2:15720853-15724668 (+)
NZO/HlLtJ ENSMUSG00225001286
 protein coding gene Chr2:25339938-25343786 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010014499
 protein coding gene Chr2:16177866-16181857 (+)
WSB/EiJ ENSIUOG00005015064
 protein coding gene Chr2:15796941-15800750 (+)



Homology
more
  • Human Ortholog
    COMMD3, COMM domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COMMD3, COMM domain containing 3
  • Synonyms
    BUP, C10orf8
  • Links
    NCBI Gene ID: 23412
    UniProt: Q9UBI1

  • Chr Location
    10p12.2; chr10:22315980-22320430 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in B cells exhibit impaired B cell migration and humoral immune responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    624
  • Tissues
    14
  • cDNA Data
    120
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12238 NCBI Gene Model | MGI Sequence Detail 3797 C57BL/6J ±  kb
    transcript NM_147778 RefSeq | MGI Sequence Detail 923 ZRU/MplStud  
    polypeptide Q63829 UniProt | EBI | MGI Sequence Detail 195 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 122
      cDNA 121
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1685, MGI:1261851, MGI:2139387
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:15805 Haupt Y, et al., Nucleotide sequence of bup, an upstream gene in the bmi-1 proviral insertion locus. Mol Biol Rep. 1992 Nov;17(1):17-20
    • Latest
      J:367422 Hancock JL, et al., COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis. J Exp Clin Cancer Res. 2023 Apr 18;42(1):90
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory