Bmyc MGI Mouse Gene Detail - MGI:88184 - brain expressed myelocytomatosis oncogene

Symbol

Bmyc
Name

brain expressed myelocytomatosis oncogene
Synonyms

2900002K07Rik

Feature Type

protein coding gene
IDs

MGI:88184
NCBI Gene: 107771
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:25596891-25597733 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 17.82 cM
Mapping Data

4 experiments

SNPs within 2kb

112 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88184	protein coding gene	Chr2:25596751-25597733 (+)
129S1/SvImJ	ENSMUSG00200048989	protein coding gene	Chr2:22580929-22581911 (+)
A/J	ENSMUSG00195041880	protein coding gene	Chr2:22671048-22672030 (+)
AKR/J	ENSMUSG00220049261	protein coding gene	Chr2:22788874-22789856 (+)
BALB/cJ	ENSMUSG00180054252	protein coding gene	Chr2:22682593-22683575 (+)
C3H/HeJ	ENSMUSG00175052916	protein coding gene	Chr2:22646746-22647728 (+)
C57BL/6NJ	ENSMUSG00215042986	protein coding gene	Chr2:22705484-22706466 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023295	protein coding gene	Chr2:21607821-21608805 (+)
CAST/EiJ	ENSTCUG00005051858	protein coding gene	Chr2:22427383-22428365 (+)
CBA/J	ENSMUSG00210016987	protein coding gene	Chr2:22685714-22686696 (+)
DBA/2J	ENSMUSG00185051606	protein coding gene	Chr2:22585224-22586206 (+)
FVB/NJ	ENSMUSG00205049539	protein coding gene	Chr2:22439554-22440536 (+)
JF1/MsJ	ENSUMUG00000043937	protein coding gene	Chr2:22503627-22504609 (+)
LP/J	ENSMUSG00230044879	protein coding gene	Chr2:24516912-24517894 (+)
NOD/ShiLtJ	ENSMUSG00190049776	protein coding gene	Chr2:22676088-22677070 (+)
NZO/HlLtJ	ENSMUSG00225009228	protein coding gene	Chr2:32267365-32268347 (+)
PWK/PhJ	ENSLUMG00010048779	protein coding gene	Chr2:22597360-22598342 (+)
SPRET/EiJ	ENSMSPG00010045675	protein coding gene	Chr2:23281877-23282859 (+)
WSB/EiJ	ENSIUOG00005052414	protein coding gene	Chr2:22543130-22544112 (+)

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MGI Vertebrate Homology

Bmyc stringent orthology
1 mouse;1 rat
Gene Tree

Bmyc

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
2 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Targeted

1
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit partial lethality, reduced body weight in male mice and abnormal male reproductive system morphology.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

667
Tissues

58
cDNA Data

43
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS15789.1

Ensembl

ENSMUSG00000049086 (Evidence)
NCBI Gene

107771

			Length	Strain/Species	Flank
genomic	107771	NCBI Gene Model \| MGI Sequence Detail	843	C57BL/6J	± kb
transcript	NM_023326	RefSeq \| MGI Sequence Detail	861	C57BL/6
polypeptide	Q6P8Z1	UniProt \| EBI \| MGI Sequence Detail	170	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010935 protein B-Myc

(term hierarchy)
InterPro Domains

IPR050433 Myc family transcription factors

IPR002418 Transcription regulator Myc

IPR012682 Transcription regulator Myc, N-terminal

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All nucleic 50

Genomic 4

cDNA 43

Primer pair 1

Other 2

Microarray probesets 3

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MGD-MRK-1606, MGI:1914503, MGI:2139289

Summaries

All 43

Developmental Gene Expression 9

Gene Ontology 5

Phenotypes 2
Earliest

J:4488 Ingvarsson S, et al., Chromosome localization and expression pattern of Lmyc and Bmyc in murine embryonal carcinoma cells. Oncogene. 1988 Dec;3(6):679-85
Latest

J:238877 Chen S, et al., Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium. Development. 2015 Mar 15;142(6):1180-92

TSS for Bmyc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16762	Chr2:25596733-25596742 (+)	-153 bp
Tssr16763	Chr2:25596755-25596806 (+)	-110 bp
Tssr16764	Chr2:25596807-25596836 (+)	-69 bp
Tssr16765	Chr2:25596838-25596925 (+)	-9 bp
Tssr16766	Chr2:25596944-25596953 (+)	58 bp
Tssr16767	Chr2:25596989-25597011 (+)	109 bp
Tssr16768	Chr2:25597133-25597136 (+)	244 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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