Bmp6
Gene Detail

Symbol Name ID

Bmp6 bone morphogenetic protein 6 MGI:88182

Synonyms

D13Wsu115e, Vgr1

Feature Type

protein coding gene

Genetic Map

Chromosome 13

18.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr13:38345716-38499728 bp, + strand From NCBI annotation of GRCm38   154013 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle    (Mammalian Orthology)
Comparative Map (Mouse/Human Bmp6 ± 2 cM)

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp6

Human ortholog

BMP6 bone morphogenetic protein 6 NCBI Gene ID 654
Human Synonyms: VGR, VGR1
Human Chr6:7727011-7881961 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

One homozygous null mutant showed delayed ossification in the developing sternum while females of a second null mutant were smaller than normal in size.

 

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	BMP signaling pathway, cartilage development, ...
Component	cytoplasm, extracellular region, ...
Function	BMP receptor binding, cytokine activity, ...

External Resources: FuncBase

Expression

Literature Summary: (76 records)
Data Summary: Results (277)    Tissues (169)    Images (67)
Theiler Stages: 1, 2, 3, 5, 9, 11, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	203
Northern blot	17
RT-PCR	53

cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(1) cDNA(19) Primer pair(8) Other(4)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000039004 (Evidence)
Entrez Gene	12161 (Evidence)
Consensus CDS Project	CCDS26462.1
International Mouse Knockout Project Status	Bmp6

Sequences

Length	Strain/Species
genomic	12161	NCBI Gene Model | MGI Sequence Detail	154013	C57BL/6J
transcript	NM_007556	RefSeq | MGI Sequence Detail	2410	C57BL/6
polypeptide	P20722	UniProt | EBI | MGI Sequence Detail	510	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(807 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002405	Inhibin, alpha subunit
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000000167	BMP6

Graphical View of Protein Domain Structure

References

(Earliest) J:9842 Lyons K, et al., Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4554-8
(Latest) J:190579 Pangas SA, Regulation of the ovarian reserve by members of the transforming growth factor beta family. Mol Reprod Dev. 2012 Oct;79(10):666-79
All references(149)

Other accession IDs

MGD-MRK-15388, MGD-MRK-15390, MGD-MRK-1604, MGD-MRK-34025, MGI:106333