About   Help   FAQ
Bmp6
Gene Detail
 Symbol
Name
ID
Bmp6
bone morphogenetic protein 6
MGI:88182
Synonyms D13Wsu115e, Vgr1
Feature Type protein coding gene
Genetic Map
Chromosome 13
18.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr13:38345716-38499728 bp, + strand
From NCBI annotation of GRCm38

  154013 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1300  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp6

Human
homologs
Human Homolog BMP6, bone morphogenetic protein 6
NCBI Gene ID 654
neXtProt AC  NX_P22004
Human Synonyms  VGR, VGR1
Human Chr (Location)  6p24-p23; chr6:7726778-7881728 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
One homozygous null mutant showed delayed ossification in the developing sternum while females of a second null mutant were smaller than normal in size.
 
Interactions
Bmp6 interacts with 88 markers (Mir17, Mir18, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process BMP signaling pathway, cartilage development, ...
Component cytoplasm, extracellular region, ...
Function BMP receptor binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (81 records)
Data Summary: Results (287)    Tissues (177)    Images (71)
Theiler Stages: 1, 2, 3, 5, 9, 11, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 209
Northern blot 17
RT-PCR 57
cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(1) cDNA(19) Primer pair(9) Other(6)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000039004 (Evidence)
Entrez Gene12161 (Evidence)
Consensus CDS ProjectCCDS26462.1
International Mouse Knockout Project StatusBmp6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12161 NCBI Gene Model | MGI Sequence Detail 154013 C57BL/6J ±  kb
transcript NM_007556 RefSeq | MGI Sequence Detail 2410 C57BL/6 
polypeptide P20722 UniProt | EBI | MGI Sequence Detail 510 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(877 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002405 Inhibin, alpha subunit
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000167 BMP6
Graphical View of Protein Domain Structure
References (Earliest) J:9842 Lyons K, et al., Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4554-8
(Latest) J:212194 Zhang Z, et al., Bmp6 expression can be regulated independently of liver iron in mice. PLoS One. 2014;9(1):e84906
All references(156)
Other
accession IDs
MGD-MRK-15388, MGD-MRK-15390, MGD-MRK-1604, MGD-MRK-34025, MGI:106333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory