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Bmp6 Gene Detail
Summary
  • Symbol
    Bmp6
  • Name
    bone morphogenetic protein 6
  • Synonyms
    D13Wsu115e, Vgr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88182
    NCBI Gene: 12161
  • Gene Overview
    MyGene.info: BMP6
Location & Maps
more
  • Sequence Map
    Chr13:38345716-38499728 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      154013 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    BMP6, bone morphogenetic protein 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BMP6, bone morphogenetic protein 6
    Orthology source: HomoloGene
  • Synonyms
    VGR, VGR1
  • Links
    NCBI Gene ID: 654
    neXtProt AC: NX_P22004

  • Chr Location
    6p24-p23; chr6:7726778-7881728 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    1 involving Bmp6
  • Incidental Mutations
    APF , CvDC
One homozygous null mutant showed delayed ossification in the developing sternum while females of a second null mutant were smaller than normal in size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12161 NCBI Gene Model | MGI Sequence Detail 154013 C57BL/6J ±  kb
transcript NM_007556 RefSeq | MGI Sequence Detail 2996 C57BL/6  
polypeptide P20722 UniProt | EBI | MGI Sequence Detail 510 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    873 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR002405 Inhibin, alpha subunit
    IPR017948 Transforming growth factor beta, conserved site
    IPR001839 Transforming growth factor-beta, C-terminal
    IPR001111 Transforming growth factor-beta, N-terminal
    IPR015615 Transforming growth factor-beta-related
Molecular
Reagents
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  • All nucleic 35
    Genomic 1
    cDNA 19
    Primer pair 9
    Other 6

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-15388, MGD-MRK-15390, MGD-MRK-1604, MGD-MRK-34025, MGI:106333
References
more
  • Summaries
    All 162
    Developmental Gene Expression 86
    Gene Ontology 19
    Phenotypes 21
  • Earliest
    J:9842 Lyons K, et al., Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4554-8
  • Latest
    J:225740 Snowball J, et al., Endodermal Wnt signaling is required for tracheal cartilage formation. Dev Biol. 2015 Sep 1;405(1):56-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory