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Bmp6 Gene Detail
Summary
  • Symbol
    Bmp6
  • Name
    bone morphogenetic protein 6
  • Synonyms
    D13Wsu115e, Vgr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88182
    NCBI Gene: 12161
  • Gene Overview
    MyGene.info: BMP6
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:38345716-38500314 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      154599 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 18.15 cM
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    BMP6, bone morphogenetic protein 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BMP6, bone morphogenetic protein 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    VGR, VGR1
  • Links
    NCBI Gene ID: 654
    neXtProt AC: NX_P22004
    UniProt: P22004

  • Chr Location
    6p24.3; chr6:7726778-7881728 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
One homozygous null mutant showed delayed ossification in the developing sternum while females of a second null mutant were smaller than normal in size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12161 NCBI Gene Model | MGI Sequence Detail 154599 C57BL/6J ±  kb
    transcript NM_007556 RefSeq | MGI Sequence Detail 2996 C57BL/6  
    polypeptide P20722 UniProt | EBI | MGI Sequence Detail 510 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      876 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 1
      cDNA 22
      Primer pair 10
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15388, MGD-MRK-15390, MGD-MRK-1604, MGD-MRK-34025, MGI:106333
    References
    more
    • Summaries
      All 186
      Developmental Gene Expression 94
      Gene Ontology 19
      Phenotypes 26
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:258267 Jovanovic VM, et al., BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells. J Neurosci. 2018 Feb 14;38(7):1662-1676

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory