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Bmp5
Gene Detail
Symbol

Name
ID
Bmp5
bone morphogenetic protein 5
MGI:88181
Feature Type
protein coding gene
Genetic Map
Chromosome 9
42.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(76)
Sequence Map
Chr9:75775364-75900310 bp, + strand
From VEGA annotation of GRCm38

  124947 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp5

Human
homologs
Human Homolog BMP5, bone morphogenetic protein 5
NCBI Gene ID 653
neXtProt AC  NX_P22003
Human Chr (Location)  6p12.1; chr6:55755438-55875590 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Chemically induced (ENU)(1) Chemically induced (other)(1) Radiation induced(15) Spontaneous(5) Targeted(4)
Genomic Mutations involving Bmp5 (1)
Incidental mutations (data from APF )
 
Homozygous recessive mutants have shortened, slightly ruffled external ears due to a defective cartilage framework affecting the whole skeleton; a series of genomic deletions of the region cause embryonic lethality.
 
Phenotype Images(1)
Interactions
Bmp5 interacts with 280 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process BMP signaling pathway, cartilage development, ...
Component extracellular region, extracellular space, ...
Function BMP receptor binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (50 records)
Data Summary: Results (296)    Tissues (158)    Images (81)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 256
Northern blot 27
RT-PCR 13
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) Genomic(5) cDNA(41) Primer pair(4) Other(4)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000021529 (Evidence)
Ensembl Gene ModelENSMUSG00000032179 (Evidence)
Entrez Gene12160 (Evidence)
UniGene428950
DFCITC1586362, TC1598553, TC1598888
DoTSDT.110614304, DT.91312064, DT.99849507
NIA Mouse Gene IndexU010757
Consensus CDS ProjectCCDS23348.1
International Mouse Knockout Project StatusBmp5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021529 VEGA Gene Model | MGI Sequence Detail 124947 C57BL/6J ±  kb
transcript OTTMUST00000051064 VEGA | MGI Sequence Detail 3822 Not Applicable 
polypeptide OTTMUSP00000023977 VEGA | MGI Sequence Detail 454 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(9)
Polymorphisms
SNPs within 2kb(689 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000166 BMP5
References
(Earliest) J:14849 Lynch CJ, Short ears, an autosomal mutation in the house mouse. Am Naturalist. 1921;55:421-426
(Latest) J:209580 Hashimoto M, et al., Molecular and cellular mechanisms of development underlying congenital diseases. Congenit Anom (Kyoto). 2014 Feb;54(1):1-7
All references(176)
Other
accession IDs
MGD-MRK-14349, MGD-MRK-1603, MGI:2143223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory