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Bmp5 Gene Detail
Summary
  • Symbol
    Bmp5
  • Name
    bone morphogenetic protein 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88181
    NCBI Gene: 12160
  • Gene Overview
    MyGene.info: BMP5
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:75775364-75900310 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 42.34 cM
  • Mapping Data
    75 experiments
Strain
Comparison
more
  • SNPs within 2kb
    662 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88181
protein coding gene Chr9:75775364-75900316 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035045
protein coding gene Chr9:76106133-76244345 (+)
A/J MGP_AJ_G0035026
protein coding gene Chr9:73456288-73584547 (+)
AKR/J MGP_AKRJ_G0034955
protein coding gene Chr9:75198294-75325515 (+)
BALB/cJ MGP_BALBcJ_G0035018
protein coding gene Chr9:73120452-73247193 (+)
C3H/HeJ MGP_C3HHeJ_G0034727
protein coding gene Chr9:75678180-75808910 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035536
protein coding gene Chr9:78125328-78262278 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032447
protein coding gene Chr9:72783950-72909714 (+)
CAST/EiJ MGP_CASTEiJ_G0034049
protein coding gene Chr9:76014132-76151349 (+)
CBA/J MGP_CBAJ_G0034699
protein coding gene Chr9:80808136-80956566 (+)
DBA/2J MGP_DBA2J_G0034859
protein coding gene Chr9:73117397-73247421 (+)
FVB/NJ MGP_FVBNJ_G0034801
protein coding gene Chr9:72414548-72539768 (+)
LP/J MGP_LPJ_G0034940
protein coding gene Chr9:76343876-76488793 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034842
protein coding gene Chr9:81896059-82038995 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035559
protein coding gene Chr9:75372878-75504476 (+)
PWK/PhJ MGP_PWKPhJ_G0033753
protein coding gene Chr9:73393552-73522903 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033586
protein coding gene Chr9:75593910-75728741 (+)
WSB/EiJ MGP_WSBEiJ_G0034161
protein coding gene Chr9:75284032-75424714 (+)



Homology
more
  • Human Ortholog
    BMP5, bone morphogenetic protein 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BMP5, bone morphogenetic protein 5
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 653
    neXtProt AC: NX_P22003
    UniProt: P22003

  • Chr Location
    6p12.1; chr6:55753653-55875625 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Bmp5 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    96 phenotypes from 21 alleles in 19 genetic backgrounds
    11 phenotypes from multigenic genotypes
    1 images
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous recessive mutants have shortened, slightly ruffled external ears due to a defective cartilage framework affecting the whole skeleton; a series of genomic deletions of the region cause embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032179 Ensembl Gene Model | MGI Sequence Detail 124947 C57BL/6J ±  kb
    transcript ENSMUST00000012281 Ensembl | MGI Sequence Detail 3822 Not Applicable  
    polypeptide ENSMUSP00000012281 Ensembl | MGI Sequence Detail 454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 5
      cDNA 42
      Primer pair 4
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14349, MGD-MRK-1603, MGI:2143223
    References
    more
    • Summaries
      All 193
      Developmental Gene Expression 63
      Diseases 1
      Gene Ontology 12
      Phenotypes 55
    • Earliest
      J:14849 Lynch CJ, Short ears, an autosomal mutation in the house mouse. Am Naturalist. 1921;55:421-426
    • Latest
      J:265181 Kim BJ, et al., RERE deficiency leads to decreased expression of GATA4 and the development of ventricular septal defects. Dis Model Mech. 2018 Aug 28;11(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory