Bmp5
Gene Detail

Symbol Name ID

Bmp5 bone morphogenetic protein 5 MGI:88181

Feature Type

protein coding gene

Genetic Map

Chromosome 9

42.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(76)

Sequence Map

Chr9:75775364-75900310 bp, + strand From VEGA annotation of GRCm38   124947 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp5

Human homologs

Human Homolog		BMP5, bone morphogenetic protein 5
NCBI Gene ID		653
neXtProt AC		NX_P22003
Human Chr (Location)		6p12.1; chr6:55620236-55740375 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(25) : Targeted(4) Spontaneous(5) Chemically induced(2) Radiation induced(14)
 

Homozygous recessive mutants have shortened, slightly ruffled external ears due to a defective cartilage framework affecting the whole skeleton; a series of genomic deletions of the region cause embryonic lethality.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	cartilage development, cell differentiation, ...
Component	extracellular region, extracellular space, ...
Function	BMP receptor binding, cytokine activity, ...

External Resources: FuncBase

Expression

Literature Summary: (45 records)
Data Summary: Results (242)    Tissues (127)    Images (67)
Theiler Stages: 9, 11, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	217
Northern blot	12
RT-PCR	13

cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(53) Genomic(5) cDNA(40) Primer pair(4) Other(4)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000021529 (Evidence)
Ensembl Gene Model	ENSMUSG00000032179 (Evidence)
Entrez Gene	12160 (Evidence)
UniGene	428950
DFCI	TC1586362, TC1598553, TC1598888
DoTS	DT.110614304, DT.91312064, DT.99849507
NIA Mouse Gene Index	U010757
Consensus CDS Project	CCDS23348.1
International Mouse Knockout Project Status	Bmp5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021529	VEGA Gene Model | MGI Sequence Detail	124947	C57BL/6J
transcript	OTTMUST00000051064	VEGA | MGI Sequence Detail	3822	Not Applicable
polypeptide	OTTMUSP00000023977	VEGA | MGI Sequence Detail	454	Not Applicable

All sequences(36) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(451 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000000166	BMP5

References

(Earliest) J:14849 Lynch CJ, Short ears, an autosomal mutation in the house mouse. Am Naturalist. 1921;55:421-426
(Latest) J:187117 Xu J, et al., Fstl1 antagonizes BMP signaling and regulates ureter development. PLoS One. 2012;7(4):e32554
All references(169)

Other accession IDs

MGD-MRK-14349, MGD-MRK-1603, MGI:2143223