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Bmp5 Gene Detail
Summary
  • Symbol
    Bmp5
  • Name
    bone morphogenetic protein 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88181
    NCBI Gene: 12160
  • Gene Overview
    MyGene.info: BMP5
Location & Maps
more
  • Sequence Map
    Chr9:75775364-75900310 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      124947 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 42.34 cM
  • Mapping Data
    75 experiments
Homology
more
  • Human Ortholog
    BMP5, bone morphogenetic protein 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BMP5, bone morphogenetic protein 5
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 653
    neXtProt AC: NX_P22003

  • Chr Location
    6p12.1; chr6:55753653-55875593 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    88 phenotypes from 21 alleles in 19 genetic backgrounds
    11 phenotypes from multigenic genotypes
    1 images
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Radiation induced
    15
  • Spontaneous
    5
  • Targeted
    4
  • Genomic Mutations
    7 involving Bmp5
  • Incidental Mutations
    APF
Homozygous recessive mutants have shortened, slightly ruffled external ears due to a defective cartilage framework affecting the whole skeleton; a series of genomic deletions of the region cause embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021529 VEGA Gene Model | MGI Sequence Detail 124947 C57BL/6J ±  kb
transcript OTTMUST00000051064 VEGA | MGI Sequence Detail 3822 Not Applicable  
polypeptide OTTMUSP00000023977 VEGA | MGI Sequence Detail 454 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    662 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 54
    Genomic 5
    cDNA 41
    Primer pair 4
    Other 4

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-14349, MGD-MRK-1603, MGI:2143223
References
more
  • Summaries
    All 175
    Developmental Gene Expression 55
    Gene Ontology 10
    Phenotypes 52
  • Earliest
    J:14849 Lynch CJ, Short ears, an autosomal mutation in the house mouse. Am Naturalist. 1921;55:421-426
  • Latest
    J:235682 Villacorte M, et al., Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly. Development. 2016 Jun 1;143(11):1958-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory