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Bmp3 Gene Detail
Summary
  • Symbol
    Bmp3
  • Name
    bone morphogenetic protein 3
  • Synonyms
    9530029I04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88179
    NCBI Gene: 110075
  • Gene Overview
    MyGene.info: BMP3
Location & Maps
more
  • Sequence Map
    Chr5:98854415-98884396 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29982 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 48.24 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    BMP3, bone morphogenetic protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BMP3, bone morphogenetic protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BMP-3A
  • Links
    NCBI Gene ID: 651
    neXtProt AC: NX_P12645

  • Chr Location
    4q21.21; chr4:81030622-81057531 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    3 involving Bmp3
  • Incidental Mutations
Homozygous mutation of this gene results in increased bone density.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053551 VEGA Gene Model | MGI Sequence Detail 29982 C57BL/6J ±  kb
transcript OTTMUST00000133520 VEGA | MGI Sequence Detail 6609 Not Applicable  
polypeptide OTTMUSP00000070953 VEGA | MGI Sequence Detail 470 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    304 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 17
    Primer pair 2
    Other 3

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-1601, MGI:2442431
References
more
  • Summaries
    All 58
    Developmental Gene Expression 27
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:10440 Dickinson ME, et al., Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. Genomics. 1990 Mar;6(3):505-20
  • Latest
    J:207903 Bialek P, et al., A myostatin and activin decoy receptor enhances bone formation in mice. Bone. 2014 Mar;60:162-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory