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Bmp1
Gene Detail
 Symbol
Name
ID
Bmp1
bone morphogenetic protein 1
MGI:88176
Feature Type protein coding gene
Genetic Map
Chromosome 14
36.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr14:70474557-70520260 bp, - strand
From Ensembl annotation of GRCm38

  45704 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55955  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: tolloid-like protein
Gene Tree: Bmp1

Human
homologs
Human Homolog BMP1, bone morphogenetic protein 1
NCBI Gene ID 649
neXtProt AC  NX_P13497
Human Synonyms  OI13, PCOLC, PCP, PCP2, TLD
Human Chr (Location)  8p21.3; chr8:22165140-22212326 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human BMP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutant embryos have reduced ossification of the skull, persistent herniation of the gut, abnormal collagen fibrils in the amnion, and die at birth.
 
Interactions
Bmp1 interacts with 93 markers (Mir18b, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cartilage development, cell differentiation, ...
Component extracellular region, extracellular space, ...
Function calcium ion binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (126)    Tissues (85)    Images (29)
Theiler Stages: 9, 11, 13, 15, 17, 18, 19, 20, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 111
Northern blot 2
RT-PCR 5
RNase protection 8
cDNA source data(143)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(149) Genomic(1) cDNA(145) Primer pair(1) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000022098 (Evidence)
Entrez Gene12153 (Evidence)
UniGene27757
DFCITC1576797, TC1602141, TC1607725, TC1615894
DoTSDT.101735951, DT.40163755, DT.534371, DT.87050504
NIA Mouse Gene IndexU035748
EC3.4.24.19
Consensus CDS ProjectCCDS36972.1
International Mouse Knockout Project StatusBmp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022098 Ensembl Gene Model | MGI Sequence Detail 45704 C57BL/6J ±  kb
transcript ENSMUST00000022693 Ensembl | MGI Sequence Detail 3757 Not Applicable 
polypeptide ENSMUSP00000022693 Ensembl | MGI Sequence Detail 991 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(22) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015446 Bone morphogenetic protein 1/tolloid-like protein
InterPro IPR000859 CUB domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001506 Peptidase M12A, astacin
InterPro IPR006026 Peptidase, metallopeptidase
Protein Ontology PR:000004771 bone morphogenetic protein 1
References (Earliest) J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
(Latest) J:201148 Lee YS, et al., Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):E3713-22
All references(63)
Other
accession IDs
MGD-MRK-1592

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory