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Bmp1
Gene Detail
Symbol

Name
ID
Bmp1
bone morphogenetic protein 1
MGI:88176
Feature Type
protein coding gene
Genetic Map
Chromosome 14
36.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr14:70474557-70520260 bp, - strand
From Ensembl annotation of GRCm38

  45704 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55955  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

HCOP human homology predictions: BMP1
Protein SuperFamily: tolloid-like protein
Gene Tree: Bmp1

Human
homologs
BMP1, bone morphogenetic protein 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 649
neXtProt AC: NX_P13497

Human Synonyms: OI13, PCOLC, PCP, PCP2, TLD

Human Chr (Location): 8p21.3; chr8:22165140-22212326 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human BMP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous targeted mutant embryos have reduced ossification of the skull, persistent herniation of the gut, abnormal collagen fibrils in the amnion, and die at birth.
 
Interactions
Bmp1 interacts with 93 markers (Mir18b, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cartilage development, cell differentiation, ...
Component extracellular region, extracellular space, ...
Function calcium ion binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (126)    Tissues (86)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 111
Northern blot 2
RT-PCR 5
RNase protection 8
cDNA source data(143)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase bmp1    NEW 
Molecular
reagents
All nucleic(149) Genomic(1) cDNA(145) Primer pair(1) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000022098 (Evidence)
Entrez Gene 12153 (Evidence)
UniGene 27757
DFCI TC1576797, TC1602141, TC1607725, TC1615894
DoTS DT.101735951, DT.40163755, DT.534371, DT.87050504
NIA Mouse Gene Index U035748
EC 3.4.24.-, 3.4.24.19
Consensus CDS Project CCDS36972.1
International Mouse Phenotyping Consortium Status Bmp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022098 Ensembl Gene Model | MGI Sequence Detail 45704 C57BL/6J ±  kb
transcript ENSMUST00000022693 Ensembl | MGI Sequence Detail 3757 Not Applicable 
polypeptide ENSMUSP00000022693 Ensembl | MGI Sequence Detail 991 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(17) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015446 Bone morphogenetic protein 1/tolloid-like protein
InterPro IPR000859 CUB domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001506 Peptidase M12A, astacin
InterPro IPR006026 Peptidase, metallopeptidase
Protein Ontology PR:000004771 bone morphogenetic protein 1
References
(Earliest) J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
(Latest) J:213829 Bard-Chapeau EA, et al., Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. PLoS One. 2014;9(2):e89397
All references(64)
Other
accession IDs
MGD-MRK-1592

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory