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Manba Gene Detail
Summary
  • Symbol
    Manba
  • Name
    mannosidase, beta A, lysosomal
  • Synonyms
    2410030O07Rik, B930014J03Rik, Bmn
  • Feature Type
    protein coding gene
  • IDs
    MGI:88175
    NCBI Gene: 110173
  • Gene Overview
    MyGene.info: MANBA
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:135485611-135571404 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 62.65 cM, cytoband H2
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    649 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88175
protein coding gene Chr3:135485594-135571404 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027908
protein coding gene Chr3:138373454-138478459 (+)
A/J MGP_AJ_G0027866
protein coding gene Chr3:133515562-133609687 (+)
AKR/J MGP_AKRJ_G0027831
protein coding gene Chr3:137045245-137146437 (+)
BALB/cJ MGP_BALBcJ_G0027879
protein coding gene Chr3:133365537-133459834 (+)
C3H/HeJ MGP_C3HHeJ_G0027608
protein coding gene Chr3:137382715-137488243 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028322
protein coding gene Chr3:143204745-143304476 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025660
protein coding gene Chr3:128751818-128830581 (+)
CAST/EiJ MGP_CASTEiJ_G0027064
protein coding gene Chr3:137128335-137213939 (+)
CBA/J MGP_CBAJ_G0027584
protein coding gene Chr3:148046309-148146000 (+)
DBA/2J MGP_DBA2J_G0027724
protein coding gene Chr3:132674484-132759014 (+)
FVB/NJ MGP_FVBNJ_G0027691
protein coding gene Chr3:130162909-130251425 (+)
LP/J MGP_LPJ_G0027834
protein coding gene Chr3:139813897-139904368 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027722
protein coding gene Chr3:156169587-156269816 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028380
protein coding gene Chr3:136587833-136678549 (+)
PWK/PhJ MGP_PWKPhJ_G0026788
protein coding gene Chr3:132392261-132479858 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026614
protein coding gene Chr3:134661040-134759976 (+)
WSB/EiJ MGP_WSBEiJ_G0027143
protein coding gene Chr3:137370960-137474404 (+)



Homology
more
  • Human Ortholog
    MANBA, mannosidase beta
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MANBA, mannosidase beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MANB1
  • Links
    NCBI Gene ID: 4126
    neXtProt AC: NX_O00462
    UniProt: O00462

  • Chr Location
    4q24; chr4:102631486-102760998 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4317
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MANBA
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Manba mouse models; 1 with human MANBA associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation results in no dysmorphology or overt neurological problems. Homozygotes show no beta-mannosidase activity and display consistent cytoplasmic vacuolation in the central nervous system and minimal vacuolation in most visceral organs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028164 Ensembl Gene Model | MGI Sequence Detail 85794 C57BL/6J ±  kb
    transcript ENSMUST00000029814 Ensembl | MGI Sequence Detail 3675 Not Applicable  
    polypeptide ENSMUSP00000029814 Ensembl | MGI Sequence Detail 879 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
    • InterPro Domains
      IPR036156 Beta-Galactosidase/glucuronidase domain superfamily
      IPR008979 Galactose-binding-like domain superfamily
      IPR006103 Glycoside hydrolase family 2, catalytic domain
      IPR017853 Glycoside hydrolase superfamily
      IPR006104 Glycosyl hydrolases family 2, sugar binding domain
      IPR013783 Immunoglobulin-like fold
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 66
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1591, MGI:1917263, MGI:2444642
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:9140 Lundin LG, A gene (Bmn) controlling beta-mannosidase activity in the mouse is located in the distal part of chromosome 3. Biochem Genet. 1987 Aug;25(7-8):603-10
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory