Manba
Gene Detail

Symbol Name ID

Manba mannosidase, beta A, lysosomal MGI:88175

Synonyms

2410030O07Rik, B930014J03Rik, Bmn

Feature Type

protein coding gene

Genetic Map

Chromosome 3

62.65 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr3:135485611-135571404 bp, + strand From VEGA annotation of GRCm38   85794 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Manba

Human homologs

Human Homolog		MANBA, mannosidase, beta A, lysosomal
NCBI Gene ID		4126
neXtProt AC		NX_O00462
Human Synonyms		MANB1
Human Chr (Location)		4q22-q25; chr4:103552643-103682151 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MANBA

Alleles and phenotypes

All alleles(253) : Targeted(2) Gene trapped(251)
 

Homozygous mutation results in no dysmorphology or overt neurological problems. Homozygotes show no beta-mannosidase activity and display consistent cytoplasmic vacuolation in the central nervous system and minimal vacuolation in most visceral organs.

 
Human Diseases Modeled Using Mouse Manba (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	carbohydrate metabolic process, glycoprotein catabolic process, ...
Component	lysosome
Function	beta-mannosidase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (130)    Tissues (96)    Images (12)
Theiler Stages: 2, 3, 22

Assay Type	Results
RNA in situ	94
RT-PCR	36

cDNA source data(65)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(68) cDNA(65) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000030307 (Evidence)
Ensembl Gene Model	ENSMUSG00000028164 (Evidence)
Entrez Gene	110173 (Evidence)
UniGene	280536
DFCI	TC1574704, TC1609824, TC1631751, TC1652640
DoTS	DT.101184567, DT.101389412, DT.101735961, DT.102537353, DT.530427, DT.94148992
NIA Mouse Gene Index	U003890
EC	3.2.1.25
Consensus CDS Project	CCDS17857.1
International Mouse Knockout Project Status	Manba

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030307	VEGA Gene Model | MGI Sequence Detail	85794	C57BL/6J
transcript	OTTMUST00000075040	VEGA | MGI Sequence Detail	3675	Not Applicable
polypeptide	OTTMUSP00000039270	VEGA | MGI Sequence Detail	879	Not Applicable

All sequences(61) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(495 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR013781	Glycoside hydrolase, catalytic domain
InterPro	IPR006104	Glycoside hydrolase, family 2, N-terminal
InterPro	IPR006103	Glycoside hydrolase, family 2, TIM barrel
InterPro	IPR017853	Glycoside hydrolase, superfamily
Protein Ontology	PR:000010110	beta-mannosidase

References

(Earliest) J:32783 Lundin LG, et al., A major locus controlling beta-mannosidase is located on Chromosome 3. Mouse News Lett. 1986;76:66
(Latest) J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
All references(44)

Other accession IDs

MGD-MRK-1591, MGI:1917263, MGI:2444642