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Manba
Gene Detail
 Symbol
Name
ID
Manba
mannosidase, beta A, lysosomal
MGI:88175
Synonyms 2410030O07Rik, B930014J03Rik, Bmn
Feature Type protein coding gene
Genetic Map
Chromosome 3
62.65 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr3:135485611-135571404 bp, + strand
From VEGA annotation of GRCm38

  85794 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Manba

Human
homologs
Human Homolog MANBA, mannosidase, beta A, lysosomal
NCBI Gene ID 4126
neXtProt AC  NX_O00462
Human Synonyms  MANB1
Human Chr (Location)  4q24; chr4:102631486-102760994 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MANBA
Alleles
and
phenotypes
All alleles(253) : Gene trapped(251) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation results in no dysmorphology or overt neurological problems. Homozygotes show no beta-mannosidase activity and display consistent cytoplasmic vacuolation in the central nervous system and minimal vacuolation in most visceral organs.
 
Human Diseases Modeled Using Mouse Manba (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process carbohydrate metabolic process, glycoprotein catabolic process, ...
Component intracellular membrane-bounded organelle, lysosome
Function beta-mannosidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (130)    Tissues (96)    Images (12)
Theiler Stages: 2, 3, 22
Assay TypeResults
RNA in situ 94
RT-PCR 36
cDNA source data(65)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(68) cDNA(65) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000030307 (Evidence)
Ensembl Gene ModelENSMUSG00000028164 (Evidence)
Entrez Gene110173 (Evidence)
UniGene280536
DFCITC1574704, TC1609824, TC1631751, TC1652640
DoTSDT.530427, DT.101184567, DT.101389412, DT.101735961, DT.102537353, DT.94148992
NIA Mouse Gene IndexU003890
EC3.2.1.25
Consensus CDS ProjectCCDS17857.1
International Mouse Knockout Project StatusManba
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030307 VEGA Gene Model | MGI Sequence Detail 85794 C57BL/6J ±  kb
transcript OTTMUST00000075040 VEGA | MGI Sequence Detail 3675 Not Applicable 
polypeptide OTTMUSP00000039270 VEGA | MGI Sequence Detail 879 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(4) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(652 from dbSNP Build 137)    SNPs within 2kb including multiple locations(654)
Protein-related
information
ResourceIDDescription
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain
InterPro IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich
InterPro IPR006104 Glycoside hydrolase, family 2, N-terminal
InterPro IPR006103 Glycoside hydrolase, family 2, TIM barrel
InterPro IPR017853 Glycoside hydrolase, superfamily
Protein Ontology PR:000010110 beta-mannosidase
References (Earliest) J:32783 Lundin LG, et al., A major locus controlling beta-mannosidase is located on Chromosome 3. Mouse News Lett. 1986;76:66
(Latest) J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
All references(46)
Other
accession IDs
MGD-MRK-1591, MGI:1917263, MGI:2444642

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory