About   Help   FAQ
Manba Gene Detail
Summary
  • Symbol
    Manba
  • Name
    mannosidase, beta A, lysosomal
  • Synonyms
    2410030O07Rik, B930014J03Rik, Bmn
  • Feature Type
    protein coding gene
  • IDs
    MGI:88175
    NCBI Gene: 110173
  • Gene Overview
    MyGene.info: MANBA
Location & Maps
more
  • Sequence Map
    Chr3:135485611-135571404 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      85794 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 62.65 cM, cytoband H2
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    MANBA, mannosidase beta
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MANBA, mannosidase beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MANB1
  • Links
    NCBI Gene ID: 4126
    neXtProt AC: NX_O00462

  • Chr Location
    4q24; chr4:102631486-102760994 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4317
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MANBA
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Manba mouse models; 1 with human MANBA associations

Human Disease Mouse Models
       Mannosidosis, Beta A, Lysosomal; MANSB   OMIM: 248510 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    255
  • Chemically induced (other)
    1
  • Gene trapped
    251
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Manba
  • Incidental Mutations
Homozygous mutation results in no dysmorphology or overt neurological problems. Homozygotes show no beta-mannosidase activity and display consistent cytoplasmic vacuolation in the central nervous system and minimal vacuolation in most visceral organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030307 VEGA Gene Model | MGI Sequence Detail 85794 C57BL/6J ±  kb
transcript OTTMUST00000075040 VEGA | MGI Sequence Detail 3675 Not Applicable  
polypeptide OTTMUSP00000039270 VEGA | MGI Sequence Detail 879 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    649 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR008979 Galactose-binding domain-like
    IPR013781 Glycoside hydrolase, catalytic domain
    IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain
    IPR006103 Glycoside hydrolase family 2, catalytic domain
    IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich
    IPR017853 Glycoside hydrolase superfamily
    IPR006104 Glycosyl hydrolases family 2, sugar binding domain
Molecular
Reagents
less
  • All nucleic 68
    cDNA 65
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1591, MGI:1917263, MGI:2444642
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:32783 Lundin LG, et al., A major locus controlling beta-mannosidase is located on Chromosome 3. Mouse News Lett. 1986;76:66
  • Latest
    J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory