Blvra
Gene Detail

Symbol Name ID

Blvra biliverdin reductase A MGI:88170

Synonyms

0610006A11Rik, 2500001N03Rik, Blvr

Feature Type

protein coding gene

Genetic Map

Chromosome 2

61.76 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr2:127070665-127097084 bp, + strand From VEGA annotation of GRCm38   26420 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:572  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: biliverdin reductase A
Gene Tree: Blvra

Human homologs

Human Homolog		BLVRA, biliverdin reductase A
NCBI Gene ID		644
neXtProt AC		NX_P53004
Human Synonyms		BLVR, BVR, BVRA
Human Chr (Location)		7p13; chr7:43798272-43846941 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human BLVRA

Alleles and phenotypes

All alleles(30) : Targeted(2) Gene trapped(28)
 

This locus controls electrophoretic mobility of biliverdin reductase. The a allele determines a slowly migrating band in C3H/He, C57BL/H and 101/H; the b allele determines a fast band in BALB/c, CBA/Ca, TFH/H and SM/J. Heterozygotes have both parental bands.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	heme catabolic process, oxidation-reduction process
Component	cytoplasm
Function	biliverdin reductase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (4)   
Theiler Stages: 22, 28

Assay Type	Results
Immunohistochemistry	8

cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) cDNA(43)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016013 (Evidence)
Ensembl Gene Model	ENSMUSG00000001999 (Evidence)
Entrez Gene	109778 (Evidence)
UniGene	22028
DFCI	TC1579026
DoTS	DT.101387958, DT.488039, DT.94132127
NIA Mouse Gene Index	U002428
EC	1.3.1.24
Consensus CDS Project	CCDS16692.1
International Mouse Knockout Project Status	Blvra

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016013	VEGA Gene Model | MGI Sequence Detail	26420	C57BL/6J
transcript	OTTMUST00000038153	VEGA | MGI Sequence Detail	1160	Not Applicable
polypeptide	OTTMUSP00000017108	VEGA | MGI Sequence Detail	295	Not Applicable

All sequences(47) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(142 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017094	Biliverdin reductase A
InterPro	IPR015249	Biliverdin reductase, catalytic
InterPro	IPR016040	NAD(P)-binding domain
InterPro	IPR000683	Oxidoreductase, N-terminal
Protein Ontology	PR:000004765	biliverdin reductase A

References

(Earliest) J:13963 von Deimling OH, et al., Linkage of biliverdin reductase, Blvr. Mouse News Lett. 1984;70:81
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(41)

Other accession IDs

MGD-MRK-1581, MGI:1915580, MGI:1917355