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Blk
Gene Detail
Symbol

Name
ID
Blk
B lymphoid kinase
MGI:88169
Feature Type
protein coding gene
Genetic Map
Chromosome 14
33.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr14:63372837-63417187 bp, - strand
From Ensembl annotation of GRCm38

  44351 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BLK
Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Blk

Human
homologs
BLK, BLK proto-oncogene, Src family tyrosine kinase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 640
neXtProt AC: NX_P51451

Human Synonyms: MODY11

Human Chr (Location): 8p23-p22; chr8:11493991-11564599 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human BLK

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene does not result in a phenotype.
 
Interactions
Blk interacts with 103 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (59)    Tissues (43)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 18
RNA in situ 41
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(5) cDNA(28)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000014453 (Evidence)
Entrez Gene 12143 (Evidence)
UniGene 3962
DFCI TC1579306, TC1711240
DoTS DT.101236685, DT.97373155
NIA Mouse Gene Index U035669
EC 2.7.10.2
PDB 1BLJ, 1BLK
Consensus CDS Project CCDS27200.1
International Mouse Phenotyping Consortium Status Blk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000014453 Ensembl Gene Model | MGI Sequence Detail 44351 C57BL/6J ±  kb
transcript ENSMUST00000014597 Ensembl | MGI Sequence Detail 2475 Not Applicable 
polypeptide ENSMUSP00000014597 Ensembl | MGI Sequence Detail 499 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(201 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 SH3 domain
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000004758 tyrosine-protein kinase BLK
References
(Earliest) J:10210 Dymecki SM, et al., Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science. 1990 Jan 19;247(4940):332-6
(Latest) J:215083 Samuelson EM, et al., Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice. PLoS One. 2014;9(3):e92054
All references(43)
Other
accession IDs
MGD-MRK-1577

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory