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Blk Gene Detail
Summary
  • Symbol
    Blk
  • Name
    B lymphoid kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88169
    NCBI Gene: 12143
  • Gene Overview
    MyGene.info: BLK
Location & Maps
more
  • Sequence Map
    Chr14:63372837-63417187 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44351 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    BLK, BLK proto-oncogene, Src family tyrosine kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BLK, BLK proto-oncogene, Src family tyrosine kinase
    Orthology source: HomoloGene
  • Synonyms
    MODY11
  • Links
    NCBI Gene ID: 640
    neXtProt AC: NX_P51451

  • Chr Location
    8p23-p22; chr8:11493991-11564599 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human BLK associations

Human Disease Mouse Models
       Maturity-Onset Diabetes of the Young, Type 11; MODY11   OMIM: 613375
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Blk
  • Incidental Mutations
Homozygous mutation of this gene does not result in a phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000014453 Ensembl Gene Model | MGI Sequence Detail 44351 C57BL/6J ±  kb
transcript ENSMUST00000014597 Ensembl | MGI Sequence Detail 2475 Not Applicable  
polypeptide ENSMUSP00000014597 Ensembl | MGI Sequence Detail 499 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    201 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    Genomic 5
    cDNA 28

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1577
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:10210 Dymecki SM, et al., Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science. 1990 Jan 19;247(4940):332-6
  • Latest
    J:215083 Samuelson EM, et al., Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice. PLoS One. 2014;9(3):e92054

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory