About   Help   FAQ
Blk
Gene Detail
 Symbol
Name
ID
Blk
B lymphoid kinase
MGI:88169
Feature Type protein coding gene
Genetic Map
Chromosome 14
33.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr14:63372837-63417187 bp, - strand
From NCBI annotation of GRCm38

  44351 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Blk

Human
homologs
Human Homolog BLK, BLK proto-oncogene, Src family tyrosine kinase
NCBI Gene ID 640
neXtProt AC  NX_P51451
Human Synonyms  MODY11
Human Chr (Location)  8p23-p22; chr8:11494012-11564599 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human BLK
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene does not result in a phenotype.
 
Interactions
Blk interacts with 103 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process B cell receptor signaling pathway, peptidyl-tyrosine phosphorylation, ...
Component membrane, plasma membrane
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (41)    Tissues (27)    Images (13)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 41
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(5) cDNA(28)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000014453 (Evidence)
Entrez Gene12143 (Evidence)
UniGene3962
DFCITC1579306, TC1711240
DoTSDT.101236685, DT.97373155
NIA Mouse Gene IndexU035669
EC2.7.10.2
PDB1BLJ, 1BLK
Consensus CDS ProjectCCDS27200.1
International Mouse Knockout Project StatusBlk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12143 NCBI Gene Model | MGI Sequence Detail 44351 C57BL/6J ±  kb
transcript NM_007549 RefSeq | MGI Sequence Detail 2475 NOD 
polypeptide P16277 UniProt | EBI | MGI Sequence Detail 499 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(201 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000004758 tyrosine-protein kinase BLK
Graphical View of Protein Domain Structure
References (Earliest) J:10210 Dymecki SM, et al., Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science. 1990 Jan 19;247(4940):332-6
(Latest) J:194960 Tai G, et al., FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using hierarchical screening technique. Biol Open. 2013;2:416-423
All references(44)
Other
accession IDs
MGD-MRK-1577

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory