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Bgn
Gene Detail
 Symbol
Name
ID
Bgn
biglycan
MGI:88158
Synonyms BG, SLRR1A
Feature Type protein coding gene
Genetic Map
Chromosome X
37.33 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
ChrX:73483602-73495933 bp, + strand
From VEGA annotation of GRCm38

  12332 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1293  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: class I small leucine-rich proteoglycan, decorin/asporin/byglycan types
Gene Tree: Bgn

Human
homologs
Human Homolog BGN, biglycan
NCBI Gene ID 633
neXtProt AC  NX_P21810
Human Synonyms  DSPG1, PGI, PG-S1, SLRR1A
Human Chr (Location)  Xq28; chrX:153494889-153509546 (+)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
 
Homozygous null mutants display reduced growth and develop age-dependent osteopenia. Age-related osteoporosis is associated with defects in bone marrow stromal cells, including increased apoptosis, reduced numbers of colony-forming units-fibroblastic (CFU-F), and decreased collagen production.
 
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
Component cell surface, extracellular matrix, ...
Function extracellular matrix binding, glycosaminoglycan binding
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (54)    Tissues (39)    Images (14)
Theiler Stages: 17, 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 29
Northern blot 21
RT-PCR 4
cDNA source data(326)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(341) Genomic(9) cDNA(328) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017659 (Evidence)
Ensembl Gene ModelENSMUSG00000031375 (Evidence)
Entrez Gene12111 (Evidence)
UniGene2608
DFCITC1573562, TC1592152, TC1617325
DoTSDT.101391919, DT.101391923, DT.87073537, DT.91592118, DT.99863658
NIA Mouse Gene IndexU019937
Consensus CDS ProjectCCDS30204.1
International Mouse Knockout Project StatusBgn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017659 VEGA Gene Model | MGI Sequence Detail 12332 C57BL/6J ±  kb
transcript OTTMUST00000042857 VEGA | MGI Sequence Detail 2419 Not Applicable 
polypeptide OTTMUSP00000019246 VEGA | MGI Sequence Detail 369 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(4) UniProt(6)
Polymorphisms All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR016352 Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
Protein Ontology PR:000004735 biglycan
References (Earliest) J:14605 Bianco P, et al., Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J Histochem Cytochem. 1990 Nov;38(11):1549-63
(Latest) J:203313 Liu CF, et al., A role for hedgehog signaling in the differentiation of the insertion site of the patellar tendon in the mouse. PLoS One. 2013;8(6):e65411
All references(98)
Other
accession IDs
MGD-MRK-1554

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory