About   Help   FAQ
Bgn
Gene Detail
Symbol

Name
ID
Bgn
biglycan
MGI:88158
Synonyms
BG, SLRR1A
Feature Type
protein coding gene
Genetic Map
Chromosome X
37.33 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
ChrX:73483602-73495933 bp, + strand
From VEGA annotation of GRCm38

  12332 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1293  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: class I small leucine-rich proteoglycan, decorin/asporin/byglycan types
Gene Tree: Bgn

Human
homologs
Human Homolog BGN, biglycan
NCBI Gene ID 633
neXtProt AC  NX_P21810
Human Synonyms  DSPG1, PGI, PG-S1, SLRR1A
Human Chr (Location)  Xq28; chrX:153494889-153509546 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Homozygous null mutants display reduced growth and develop age-dependent osteopenia. Age-related osteoporosis is associated with defects in bone marrow stromal cells, including increased apoptosis, reduced numbers of colony-forming units-fibroblastic (CFU-F), and decreased collagen production.
 
Interactions
Bgn interacts with 167 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (25 records)
Data Summary: Results (54)    Tissues (39)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
Northern blot 21
RT-PCR 4
cDNA source data(326)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(341) Genomic(9) cDNA(328) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017659 (Evidence)
Ensembl Gene ModelENSMUSG00000031375 (Evidence)
Entrez Gene12111 (Evidence)
UniGene2608
DFCITC1573562, TC1592152, TC1617325
DoTSDT.101391919, DT.101391923, DT.87073537, DT.91592118, DT.99863658
NIA Mouse Gene IndexU019937
Consensus CDS ProjectCCDS30204.1
International Mouse Knockout Project StatusBgn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017659 VEGA Gene Model | MGI Sequence Detail 12332 C57BL/6J ±  kb
transcript OTTMUST00000042857 VEGA | MGI Sequence Detail 2419 Not Applicable 
polypeptide OTTMUSP00000019246 VEGA | MGI Sequence Detail 369 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(4) UniProt(6)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR016352 Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
Protein Ontology PR:000004735 biglycan
References
(Earliest) J:14605 Bianco P, et al., Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J Histochem Cytochem. 1990 Nov;38(11):1549-63
(Latest) J:207829 Dupuis LE, et al., Small leucine-rich proteoglycans exhibit unique spatiotemporal expression profiles during cardiac valve development. Dev Dyn. 2014 Apr;243(4):601-11
All references(101)
Other
accession IDs
MGD-MRK-1554

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory