Bgn
Gene Detail

Symbol Name ID

Bgn biglycan MGI:88158

Synonyms

BG, SLRR1A

Feature Type

protein coding gene

Genetic Map

Chromosome X

37.33 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

ChrX:73483602-73495933 bp, + strand From VEGA annotation of GRCm38   12332 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1293  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: class I small leucine-rich proteoglycan, decorin/asporin/byglycan types
Gene Tree: Bgn

Human homologs

Human Homolog		BGN, biglycan
NCBI Gene ID		633
neXtProt AC		NX_P21810
Human Synonyms		DSPG1, PGI, PG-S1, SLRR1A
Human Chr (Location)		Xq28; chrX:152760347-152775004 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous null mutants display reduced growth and develop age-dependent osteopenia. Age-related osteoporosis is associated with defects in bone marrow stromal cells, including increased apoptosis, reduced numbers of colony-forming units-fibroblastic (CFU-F), and decreased collagen production.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
Component	cell surface, extracellular matrix, ...
Function	extracellular matrix binding, glycosaminoglycan binding

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (46)    Tissues (35)    Images (8)
Theiler Stages: 17, 20, 22, 25, 28

Assay Type	Results
RNA in situ	21
Northern blot	21
RT-PCR	4

cDNA source data(316)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(330) Genomic(9) cDNA(317) Primer pair(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000017659 (Evidence)
Ensembl Gene Model	ENSMUSG00000031375 (Evidence)
Entrez Gene	12111 (Evidence)
UniGene	2608
DFCI	TC1573562, TC1592152, TC1617325
DoTS	DT.101391919, DT.101391923, DT.87073537, DT.91592118, DT.99863658
NIA Mouse Gene Index	U019937
Consensus CDS Project	CCDS30204.1
International Mouse Knockout Project Status	Bgn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017659	VEGA Gene Model | MGI Sequence Detail	12332	C57BL/6J
transcript	OTTMUST00000042857	VEGA | MGI Sequence Detail	2377	Not Applicable
polypeptide	OTTMUSP00000019246	VEGA | MGI Sequence Detail	369	Not Applicable

All sequences(52) RefSeq(2) UniProt(6)

Polymorphisms

All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs(45 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
InterPro	IPR016352	Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
Protein Ontology	PR:000004735	biglycan

References

(Earliest) J:14605 Bianco P, et al., Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J Histochem Cytochem. 1990 Nov;38(11):1549-63
(Latest) J:194215 Dunkman AA, et al., Decorin expression is important for age-related changes in tendon structure and mechanical properties. Matrix Biol. 2013 Jan;32(1):3-13
All references(97)

Other accession IDs

MGD-MRK-1554