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Bgn
Gene Detail
Symbol

Name
ID
Bgn
biglycan
MGI:88158
Synonyms
BG, SLRR1A
Feature Type
protein coding gene
Genetic Map
Chromosome X
37.33 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
ChrX:73483602-73495933 bp, + strand
From VEGA annotation of GRCm38

  12332 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1293  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BGN
Protein SuperFamily: class I small leucine-rich proteoglycan, decorin/asporin/byglycan types
Gene Tree: Bgn

Human
homologs
BGN, biglycan
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 633
neXtProt AC: NX_P21810

Human Synonyms: DSPG1, PGI, PG-S1, SLRR1A

Human Chr (Location): Xq28; chrX:153494889-153509546 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Homozygous null mutants display reduced growth and develop age-dependent osteopenia. Age-related osteoporosis is associated with defects in bone marrow stromal cells, including increased apoptosis, reduced numbers of colony-forming units-fibroblastic (CFU-F), and decreased collagen production.
 
Interactions
Bgn interacts with 167 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (25 records)
Data Summary: Results (54)    Tissues (39)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
Northern blot 21
RT-PCR 4
cDNA source data(326)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bgn ; ZFIN bgna, bgnb    NEW 
Molecular
reagents
All nucleic(341) Genomic(9) cDNA(328) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000017659 (Evidence)
Ensembl Gene Model ENSMUSG00000031375 (Evidence)
Entrez Gene 12111 (Evidence)
UniGene 2608
DFCI TC1573562, TC1592152, TC1617325
DoTS DT.101391919, DT.101391923, DT.87073537, DT.91592118, DT.99863658
NIA Mouse Gene Index U019937
Consensus CDS Project CCDS30204.1
International Mouse Phenotyping Consortium Status Bgn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017659 VEGA Gene Model | MGI Sequence Detail 12332 C57BL/6J ±  kb
transcript OTTMUST00000042857 VEGA | MGI Sequence Detail 2419 Not Applicable 
polypeptide OTTMUSP00000019246 VEGA | MGI Sequence Detail 369 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(4) UniProt(6)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028547 Biglycan
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat N-terminal domain
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR016352 Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
Protein Ontology PR:000004735 biglycan
References
(Earliest) J:14605 Bianco P, et al., Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J Histochem Cytochem. 1990 Nov;38(11):1549-63
(Latest) J:215421 Dunkman AA, et al., The injury response of aged tendons in the absence of biglycan and decorin. Matrix Biol. 2014 Apr;35:232-8
All references(105)
Other
accession IDs
MGD-MRK-1554

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory