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Bgn Gene Detail
Summary
  • Symbol
    Bgn
  • Name
    biglycan
  • Synonyms
    BG, SLRR1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:88158
    NCBI Gene: 12111
  • Gene Overview
    MyGene.info: BGN
  • Alliance
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:73483602-73495933 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.33 cM, cytoband B
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88158
protein coding gene ChrX:73483601-73495936 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035811
protein coding gene ChrX:69233785-69247203 (+)
A/J MGP_AJ_G0035792
protein coding gene ChrX:69448634-69461612 (+)
AKR/J MGP_AKRJ_G0035717
protein coding gene ChrX:71254673-71270711 (+)
BALB/cJ MGP_BALBcJ_G0035777
protein coding gene ChrX:68481059-68493898 (+)
C3H/HeJ MGP_C3HHeJ_G0035482
protein coding gene ChrX:69712995-69728711 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036307
protein coding gene ChrX:71368584-71382173 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033151
protein coding gene ChrX:68489621-68501535 (+)
CAST/EiJ MGP_CASTEiJ_G0034773
protein coding gene ChrX:55060656-55074839 (+)
CBA/J MGP_CBAJ_G0035457
protein coding gene ChrX:73309573-73324689 (+)
DBA/2J MGP_DBA2J_G0035614
protein coding gene ChrX:68912269-68926499 (+)
FVB/NJ MGP_FVBNJ_G0035558
protein coding gene ChrX:68238386-68252395 (+)
LP/J MGP_LPJ_G0035699
protein coding gene ChrX:70036021-70048157 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035596
protein coding gene ChrX:75910250-75922790 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036329
protein coding gene ChrX:69065114-69081035 (+)
PWK/PhJ MGP_PWKPhJ_G0034472
protein coding gene ChrX:53082834-53095181 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034306
protein coding gene ChrX:55978583-55992385 (+)
WSB/EiJ MGP_WSBEiJ_G0034914
protein coding gene ChrX:68338577-68353337 (+)



Homology
more
  • Human Ortholog
    BGN, biglycan
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BGN, biglycan
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DSPG1, MRLS, PGI, PG-S1, SEMDX, SLRR1A
  • Links
    NCBI Gene ID: 633
    neXtProt AC: NX_P21810
    UniProt: P21810

  • Chr Location
    Xq28; chrX:153494889-153509554 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 3 genetic backgrounds
    34 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants display reduced growth and develop age-dependent osteopenia. Age-related osteoporosis is associated with defects in bone marrow stromal cells, including increased apoptosis, reduced numbers of colony-forming units-fibroblastic (CFU-F), and decreased collagen production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031375 Ensembl Gene Model | MGI Sequence Detail 12332 C57BL/6J ±  kb
    transcript ENSMUST00000033741 Ensembl | MGI Sequence Detail 2419 Not Applicable  
    polypeptide ENSMUSP00000033741 Ensembl | MGI Sequence Detail 369 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 342
      Genomic 9
      cDNA 329
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1554
    References
    more
    • Summaries
      All 131
      Developmental Gene Expression 35
      Diseases 4
      Gene Ontology 9
      Phenotypes 54
    • Earliest
      J:14605 Bianco P, et al., Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J Histochem Cytochem. 1990 Nov;38(11):1549-63
    • Latest
      J:264602 Gamer LW, et al., The Role of Bmp2 in the Maturation and Maintenance of the Murine Knee Joint. J Bone Miner Res. 2018 Sep;33(9):1708-1717

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory