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Bdkrb1 Gene Detail
Summary
  • Symbol
    Bdkrb1
  • Name
    bradykinin receptor, beta 1
  • Synonyms
    B1R, kinin B1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88144
    NCBI Gene: 12061
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr12:105570350-105571770 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 55.81 cM, cytoband F1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    63 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88144
protein coding gene Chr12:105569344-105571770 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020092
protein coding gene Chr12:107484180-107486523 (+)
A/J MGP_AJ_G0020046
protein coding gene Chr12:103468965-103471308 (+)
AKR/J MGP_AKRJ_G0020022
protein coding gene Chr12:106472416-106474548 (+)
BALB/cJ MGP_BALBcJ_G0020032
protein coding gene Chr12:103886987-103889326 (+)
C3H/HeJ MGP_C3HHeJ_G0019834
protein coding gene Chr12:106901577-106903920 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020477
protein coding gene Chr12:110795946-110798301 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018089
protein coding gene Chr12:100079016-100081353 (+)
CAST/EiJ MGP_CASTEiJ_G0019376
protein coding gene Chr12:101704769-101707152 (+)
CBA/J MGP_CBAJ_G0019801
protein coding gene Chr12:115185920-115188052 (+)
DBA/2J MGP_DBA2J_G0019918
protein coding gene Chr12:102995072-102997407 (+)
FVB/NJ MGP_FVBNJ_G0019903
protein coding gene Chr12:101782382-101786184 (+)
LP/J MGP_LPJ_G0019993
protein coding gene Chr12:107381867-107384200 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019941
protein coding gene Chr12:118589540-118591869 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020506
protein coding gene Chr12:105854139-105856484 (+)
PWK/PhJ MGP_PWKPhJ_G0019135
protein coding gene Chr12:97588009-97590381 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018939
protein coding gene Chr12:100090334-100092678 (+)
WSB/EiJ MGP_WSBEiJ_G0019433
protein coding gene Chr12:106818090-106820436 (+)



Homology
more
  • Human Ortholog
    BDKRB1, bradykinin receptor B1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BDKRB1, bradykinin receptor B1
  • Synonyms
    B1BKR, B1R, BKB1R, BKR1, BRADYB1
  • Links
    NCBI Gene ID: 623
    neXtProt AC: NX_P46663
    UniProt: P46663

  • Chr Location
    14q32.2; chr14:96256210-96268967 (+)  GRCh38

Human Diseases
more
  • Diseases
    3 with human BDKRB1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display hypoalgesia and altered inflammatory responses while those homozygous for another are reported to have a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12061 NCBI Gene Model | MGI Sequence Detail 1421 C57BL/6J ±  kb
    transcript NM_007539 RefSeq | MGI Sequence Detail 1421 C57BL/6  
    polypeptide Q61125 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 2
      cDNA 4
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1533
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 55
    • Earliest
      J:16469 McIntyre P, et al., Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity [published erratum appears in Mol Pharmacol 1994 Mar;45(3):561]. Mol Pharmacol. 1993 Aug;44(2):346-55
    • Latest
      J:343298 Alves-Silva T, et al., Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain. iScience. 2023 Dec 15;26(12):108409

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory