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Bdkrb1 Gene Detail
Summary
  • Symbol
    Bdkrb1
  • Name
    bradykinin receptor, beta 1
  • Synonyms
    B1R, kinin B1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88144
    NCBI Gene: 12061
  • Gene Overview
    MyGene.info: BDKRB1
Location & Maps
more
  • Sequence Map
    Chr12:105603085-105605339 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2255 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 55.81 cM, cytoband F1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    BDKRB1, bradykinin receptor B1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    BDKRB1, bradykinin receptor B1
    Orthology source: HomoloGene
  • Synonyms
    B1BKR, B1R, BDKRB2, BKB1R, BKR1, BRADYB1
  • Links
    NCBI Gene ID: 623
    neXtProt AC: NX_P46663

  • Chr Location
    14q32.1-q32.2; chr14:96256210-96264763 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Bdkrb1
  • Incidental Mutations
Mice homozygous for one null allele display hypoalgesia and altered inflammatory responses while those homozygous for another are reported to have a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043609 VEGA Gene Model | MGI Sequence Detail 2255 C57BL/6J ±  kb
transcript OTTMUST00000114502 VEGA | MGI Sequence Detail 1313 Not Applicable  
polypeptide OTTMUSP00000063894 VEGA | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    67 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001171 B1 bradykinin receptor
  • InterPro Domains
    IPR001186 Bradykinin receptor B1
    IPR000496 Bradykinin receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 6
    Genomic 2
    cDNA 3
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1533
References
more
  • Summaries
    All 59
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 32
  • Earliest
    J:16469 McIntyre P, et al., Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity [published erratum appears in Mol Pharmacol 1994 Mar;45(3):561]. Mol Pharmacol. 1993 Aug;44(2):346-55
  • Latest
    J:207053 Rodi D, et al., Bradykinin B receptors increase hippocampal excitability and susceptibility to seizures in mice. Neuroscience. 2013 Jun 27;248C:392-402

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory