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Bdkrb1
Gene Detail
 Symbol
Name
ID
Bdkrb1
bradykinin receptor, beta 1
MGI:88144
Synonyms B1R, kinin B1
Feature Type protein coding gene
Genetic Map
Chromosome 12
55.81 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:105603085-105605339 bp, + strand
From VEGA annotation of GRCm38

  2255 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:570  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: bradykinin receptor
Gene Tree: Bdkrb1

Human
homologs
Human Homolog BDKRB1, bradykinin receptor B1
NCBI Gene ID 623
neXtProt AC  NX_P46663
Human Synonyms  B1BKR, B1R, BKB1R, BKR1, BRADYB1
Human Chr (Location)  14q32.1-q32.2; chr14:96256210-96264763 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null allele display hypoalgesia and altered inflammatory responses while those homozygous for another are reported to have a normal phenotype.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell migration, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function bradykinin receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (35)    Tissues (35)    Images (1)
Theiler Stages: 28
Assay TypeResults
RT-PCR 35
cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(6) Genomic(2) cDNA(3) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000043609 (Evidence)
Ensembl Gene ModelENSMUSG00000041347 (Evidence)
Entrez Gene12061 (Evidence)
UniGene377078
DFCITC1599572
DoTSDT.91594807
Consensus CDS ProjectCCDS26155.1
International Mouse Knockout Project StatusBdkrb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043609 VEGA Gene Model | MGI Sequence Detail 2255 C57BL/6J ±  kb
transcript OTTMUST00000114502 VEGA | MGI Sequence Detail 1313 Not Applicable 
polypeptide OTTMUSP00000063894 VEGA | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001186 Bradykinin receptor B1
InterPro IPR000496 Bradykinin receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001171 B1 bradykinin receptor
References (Earliest) J:16469 McIntyre P, et al., Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity [published erratum appears in Mol Pharmacol 1994 Mar;45(3):561]. Mol Pharmacol. 1993 Aug;44(2):346-55
(Latest) J:207053 Rodi D, et al., Bradykinin B receptors increase hippocampal excitability and susceptibility to seizures in mice. Neuroscience. 2013 Jun 27;248C:392-402
All references(63)
Other
accession IDs
MGD-MRK-1533

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory