Bdkrb1
Gene Detail

Symbol Name ID

Bdkrb1 bradykinin receptor, beta 1 MGI:88144

Synonyms

B1R, kinin B1

Feature Type

protein coding gene

Genetic Map

Chromosome 12

55.81 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr12:105604091-105605428 bp, + strand From NCBI annotation of GRCm38   1338 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; rabbit, European    (Mammalian Orthology)
Comparative Map (Mouse/Human Bdkrb1 ± 2 cM)

Protein SuperFamily: bradykinin receptor
Gene Tree: Bdkrb1

Human ortholog

BDKRB1 bradykinin receptor B1 NCBI Gene ID 623
Human Synonyms: B1BKR, B1R, BKB1R, BKR1, BRADYB1
Human Chr14:96722559-96731100 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for one null allele display hypoalgesia and altered inflammatory responses while those homozygous for another are reported to have a normal phenotype.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	cell migration, elevation of cytosolic calcium ion concentration, ...
Component	integral to membrane, membrane, ...
Function	bradykinin receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (35)    Tissues (35)    Images (1)
Theiler Stages: 28

Assay Type	Results
RT-PCR	35

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) Genomic(2) cDNA(3) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000041347 (Evidence)
Entrez Gene	12061 (Evidence)
UniGene	377078
DFCI	TC1599572
DoTS	DT.91594807
Consensus CDS Project	CCDS26155.1
International Mouse Knockout Project Status	Bdkrb1

Sequences

Length	Strain/Species
genomic	12061	NCBI Gene Model | MGI Sequence Detail	1338	C57BL/6J
transcript	NM_007539	RefSeq | MGI Sequence Detail	1338	129X1/SvJ
polypeptide	Q61125	UniProt | EBI | MGI Sequence Detail	334	Not Applicable

All sequences(12) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(42 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001186	B1 bradykinin receptor
InterPro	IPR000496	Bradykinin receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001171	B1 bradykinin receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:16469 McIntyre P, et al., Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity [published erratum appears in Mol Pharmacol 1994 Mar;45(3):561]. Mol Pharmacol. 1993 Aug;44(2):346-55
(Latest) J:192051 Mori MA, et al., Kinin B1 receptor in adipocytes regulates glucose tolerance and predisposition to obesity. PLoS One. 2012;7(9):e44782
All references(57)

Other accession IDs

MGD-MRK-1533