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Tff1 Gene Detail
Summary
  • Symbol
    Tff1
  • Name
    trefoil factor 1
  • Synonyms
    Bcei, PS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88135
    NCBI Gene: 21784
  • Gene Overview
    MyGene.info: TFF1
Location & Maps
more
  • Sequence Map
    Chr17:31161396-31165053 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3658 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.80 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    TFF1, trefoil factor 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TFF1, trefoil factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2
  • Links
    NCBI Gene ID: 7031
    neXtProt AC: NX_P04155

  • Chr Location
    21q22.3; chr21:42362282-42366535 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Tff1 mouse models

Human Disease Mouse Models
       Gastric Cancer   OMIM: 613659 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    8
  • Genomic Mutations
    4 involving Tff1
  • Incidental Mutations
    APF
Mice homozygous for a knockout allele exhibit small intestine and gastric mucosa abnormalities and develop antropyloric adenomas with full penetrance; one-third of homozygotes develop multifocal intraepithelial or intramucosal carcinomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020096 VEGA Gene Model | MGI Sequence Detail 3658 C57BL/6J ±  kb
transcript OTTMUST00000047791 VEGA | MGI Sequence Detail 478 Not Applicable  
polypeptide OTTMUSP00000021725 VEGA | MGI Sequence Detail 87 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    84 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 16
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1519
References
more
  • Summaries
    All 51
    Developmental Gene Expression 9
    Diseases 4
    Gene Ontology 6
    Phenotypes 25
  • Earliest
    J:12836 Lefebvre O, et al., The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression. J Cell Biol. 1993 Jul;122(1):191-8
  • Latest
    J:223581 Judd LM, et al., TFF2 deficiency exacerbates weight loss and alters immune cell and cytokine profiles in DSS colitis, and this cannot be rescued by wild-type bone marrow. Am J Physiol Gastrointest Liver Physiol. 2015 Jan 1;308(1):G12-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory