About   Help   FAQ
Tff1
Gene Detail
Symbol

Name
ID
Tff1
trefoil factor 1
MGI:88135
Synonyms
Bcei, PS2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
15.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:31161396-31165053 bp, - strand
From VEGA annotation of GRCm38

  3658 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

HCOP human homology predictions: TFF1
Protein SuperFamily: trefoil factor, types 1 and 3
Gene Tree: Tff1

Human
homologs
TFF1, trefoil factor 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7031
neXtProt AC: NX_P04155

Human Synonyms: BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2

Human Chr (Location): 21q22.3; chr21:42362282-42366535 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Genomic Mutations involving Tff1 (4)
Incidental mutations (data from APF )
 
Mice homozygous for a knockout allele exhibit small intestine and gastric mucosa abnormalities and develop antropyloric adenomas with full penetrance; one-third of homozygotes develop multifocal intraepithelial or intramucosal carcinomas.
 
Human Diseases Modeled in Mice Using Tff1 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Tff1 interacts with 35 markers (Mir92-2, Mir130a, Mir130b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell differentiation, negative regulation of cell proliferation, ...
Component cytoplasm, extracellular region, ...
Function growth factor activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (156)    Tissues (130)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 140
RT-PCR 16
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tff1    NEW 
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000020096 (Evidence)
Ensembl Gene Model ENSMUSG00000024032 (Evidence)
Entrez Gene 21784 (Evidence)
UniGene 2854
DFCI TC1653314, TC1577210
DoTS DT.527209
Consensus CDS Project CCDS37546.1
International Mouse Phenotyping Consortium Status Tff1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020096 VEGA Gene Model | MGI Sequence Detail 3658 C57BL/6J ±  kb
transcript OTTMUST00000047791 VEGA | MGI Sequence Detail 478 Not Applicable 
polypeptide OTTMUSP00000021725 VEGA | MGI Sequence Detail 87 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000519 P-type trefoil
InterPro IPR017994 P-type trefoil, chordata
InterPro IPR017957 P-type trefoil, conserved site
Protein Ontology PR:000016274 trefoil factor 1
References
(Earliest) J:12836 Lefebvre O, et al., The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression. J Cell Biol. 1993 Jul;122(1):191-8
(Latest) J:186161 Hu B, et al., Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
All references(51)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1519

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory