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Tff1
Gene Detail
 Symbol
Name
ID
Tff1
trefoil factor 1
MGI:88135
Synonyms Bcei, PS2
Feature Type protein coding gene
Genetic Map
Chromosome 17
15.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:31161396-31165053 bp, - strand
From VEGA annotation of GRCm38

  3658 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: trefoil factor, types 1 and 3
Gene Tree: Tff1

Human
homologs
Human Homolog TFF1, trefoil factor 1
NCBI Gene ID 7031
neXtProt AC  NX_P04155
Human Synonyms  BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2
Human Chr (Location)  21q22.3; chr21:42362282-42366535 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a knockout allele exhibit small intestine and gastric mucosa abnormalities and develop antropyloric adenomas with full penetrance; one-third of homozygotes develop multifocal intraepithelial or intramucosal carcinomas.
 
Human Diseases Modeled Using Mouse Tff1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell differentiation, negative regulation of cell proliferation, ...
Component cytoplasm, extracellular region, ...
Function growth factor activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (156)    Tissues (130)    Images (8)
Theiler Stages: 13, 15, 17, 20, 22, 26, 28
Assay TypeResults
RNA in situ 140
RT-PCR 16
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020096 (Evidence)
Ensembl Gene ModelENSMUSG00000024032 (Evidence)
Entrez Gene21784 (Evidence)
UniGene2854
DFCITC1577210, TC1653314
DoTSDT.527209
Consensus CDS ProjectCCDS37546.1
International Mouse Knockout Project StatusTff1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020096 VEGA Gene Model | MGI Sequence Detail 3658 C57BL/6J ±  kb
transcript OTTMUST00000047791 VEGA | MGI Sequence Detail 478 Not Applicable 
polypeptide OTTMUSP00000021725 VEGA | MGI Sequence Detail 87 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000519 P-type trefoil
InterPro IPR017994 P-type trefoil, chordata
InterPro IPR017957 P-type trefoil, conserved site
Protein Ontology PR:000016274 trefoil factor 1
References (Earliest) J:12836 Lefebvre O, et al., The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression. J Cell Biol. 1993 Jul;122(1):191-8
(Latest) J:186161 Hu B, et al., Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
All references(50)
Other
accession IDs
MGD-MRK-1519

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory