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Tff1 Gene Detail
Summary
  • Symbol
    Tff1
  • Name
    trefoil factor 1
  • Synonyms
    Bcei, PS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88135
    NCBI Gene: 21784
  • Gene Overview
    MyGene.info: TFF1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:31161396-31165053 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.80 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88135
protein coding gene Chr17:31161395-31165062 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023483
protein coding gene Chr17:30901100-30904762 (-)
A/J MGP_AJ_G0023441
protein coding gene Chr17:29891963-29895620 (-)
AKR/J MGP_AKRJ_G0023406
protein coding gene Chr17:30136245-30139902 (-)
BALB/cJ MGP_BALBcJ_G0023446
protein coding gene Chr17:29999338-30003000 (-)
C3H/HeJ MGP_C3HHeJ_G0023207
protein coding gene Chr17:30522024-30525681 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023888
protein coding gene Chr17:31967973-31971630 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021362
protein coding gene Chr17:27032518-27036175 (-)
CAST/EiJ MGP_CASTEiJ_G0022708
protein coding gene Chr17:30550057-30553714 (-)
CBA/J MGP_CBAJ_G0023182
protein coding gene Chr17:33393794-33397451 (-)
DBA/2J MGP_DBA2J_G0023312
protein coding gene Chr17:29309796-29313458 (-)
FVB/NJ MGP_FVBNJ_G0023282
protein coding gene Chr17:29092768-29096421 (-)
LP/J MGP_LPJ_G0023390
protein coding gene Chr17:31120423-31124085 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023300
protein coding gene Chr17:32454838-32458490 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023930
protein coding gene Chr17:30511787-30515444 (-)
PWK/PhJ MGP_PWKPhJ_G0022458
protein coding gene Chr17:28125366-28129018 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022276
protein coding gene Chr17:28496897-28500550 (-)
WSB/EiJ MGP_WSBEiJ_G0022770
protein coding gene Chr17:30469675-30473332 (-)



Homology
more
  • Human Ortholog
    TFF1, trefoil factor 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TFF1, trefoil factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2
  • Links
    NCBI Gene ID: 7031
    neXtProt AC: NX_P04155
    UniProt: P04155

  • Chr Location
    21q22.3; chr21:42362282-42366535 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tff1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit small intestine and gastric mucosa abnormalities and develop antropyloric adenomas with full penetrance; one-third of homozygotes develop multifocal intraepithelial or intramucosal carcinomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024032 Ensembl Gene Model | MGI Sequence Detail 3658 C57BL/6J ±  kb
    transcript ENSMUST00000024831 Ensembl | MGI Sequence Detail 478 Not Applicable  
    polypeptide ENSMUSP00000024831 Ensembl | MGI Sequence Detail 87 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1519
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 9
      Diseases 4
      Gene Ontology 7
      Phenotypes 32
    • Earliest
      J:12836 Lefebvre O, et al., The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression. J Cell Biol. 1993 Jul;122(1):191-8
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory