Slc7a1
Gene Detail

Symbol Name ID

Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 MGI:88117

Synonyms

4831426K01Rik, Atrc1, Atrc-1, Cat1, mCAT-1, Rec-1, Rev-1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

88.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)

Sequence Map

Chr5:148327410-148399904 bp, - strand From VEGA annotation of GRCm38   72495 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20658  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a1

Human homologs

Human Homolog		SLC7A1, solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
NCBI Gene ID		6541
neXtProt AC		NX_P30825
Human Synonyms		ATRC1, CAT-1, ERR, HCAT1, REC1L
Human Chr (Location)		13q12.3; chr13:30083551-30169825 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(94) : Targeted(3) Gene trapped(91)
 

Homozygous mutants die on the first day of birth and are very anemic. Peripheral blood contains 50% fewer red blood cells, reduced hemoglobin levels, and a defect in erythroid maturation.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	amino acid transmembrane transport, amino acid transport, ...
Component	integral to membrane, membrane, ...
Function	amino acid transmembrane transporter activity, arginine transmembrane transporter activity

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (288)    Tissues (59)    Images (25)
Theiler Stages: 10, 12, 21, 23, 28

Assay Type	Results
RNA in situ	273
RT-PCR	15

cDNA source data(80)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(82) cDNA(80) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000025707 (Evidence)
Ensembl Gene Model	ENSMUSG00000041313 (Evidence)
Entrez Gene	11987 (Evidence)
UniGene	275489
DFCI	TC1581284, TC1614210, TC1622880, TC1649199, TC1717194
DoTS	DT.101253405, DT.101354968, DT.91333486, DT.91390842
NIA Mouse Gene Index	U099444
Consensus CDS Project	CCDS19882.1
International Mouse Knockout Project Status	Slc7a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025707	VEGA Gene Model | MGI Sequence Detail	72495	C57BL/6J
transcript	OTTMUST00000063315	VEGA | MGI Sequence Detail	7179	Not Applicable
polypeptide	OTTMUSP00000031291	VEGA | MGI Sequence Detail	622	Not Applicable

All sequences(55) RefSeq(2) UniProt(8)

Polymorphisms

RFLP(3) : SNPs(487 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002293	Amino acid/polyamine transporter I
InterPro	IPR015606	Cationic amino acid transporter
InterPro	IPR004755	Cationic amino acid transport permease
Protein Ontology	PR:000015194	high affinity cationic amino acid transporter 1

References

(Earliest) J:5854 Gazdar AF, et al., Identification of mouse chromosomes required for murine leukemia virus replication. Cell. 1977 Aug;11(4):949-56
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(63)

Other accession IDs

MGD-MRK-13821, MGD-MRK-13847, MGD-MRK-1478, MGD-MRK-1479, MGI:2140881