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Slc7a1
Gene Detail
Symbol

Name
ID
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
MGI:88117
Synonyms
4831426K01Rik, Atrc1, Atrc-1, Cat1, mCAT-1, Rec-1, Rev-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
88.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr5:148327410-148399904 bp, - strand
From VEGA annotation of GRCm38

  72495 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20658  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a1

Human
homologs
Human Homolog SLC7A1, solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
NCBI Gene ID 6541
neXtProt AC  NX_P30825
Human Synonyms  ATRC1, CAT-1, ERR, HCAT1, REC1L
Human Chr (Location)  13q12.3; chr13:29509414-29595688 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(94) : Gene trapped(91) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants die on the first day of birth and are very anemic. Peripheral blood contains 50% fewer red blood cells, reduced hemoglobin levels, and a defect in erythroid maturation.
 
Interactions
Slc7a1 interacts with 399 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (288)    Tissues (59)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 273
RT-PCR 15
cDNA source data(84)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(86) cDNA(84) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025707 (Evidence)
Ensembl Gene ModelENSMUSG00000041313 (Evidence)
Entrez Gene11987 (Evidence)
UniGene275489
DFCITC1581284, TC1614210, TC1622880, TC1649199, TC1717194
DoTSDT.101253405, DT.101354968, DT.91333486, DT.91390842
NIA Mouse Gene IndexU099444
Consensus CDS ProjectCCDS19882.1
International Mouse Knockout Project StatusSlc7a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025707 VEGA Gene Model | MGI Sequence Detail 72495 C57BL/6J ±  kb
transcript OTTMUST00000063315 VEGA | MGI Sequence Detail 7179 Not Applicable 
polypeptide OTTMUSP00000031291 VEGA | MGI Sequence Detail 622 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(8) UniProt(15)
Polymorphisms
RFLP(3) : SNPs within 2kb(640 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002293 Amino acid/polyamine transporter I
InterPro IPR004755 Cationic amino acid transport permease
Protein Ontology PR:000015194 high affinity cationic amino acid transporter 1
References
(Earliest) J:5854 Gazdar AF, et al., Identification of mouse chromosomes required for murine leukemia virus replication. Cell. 1977 Aug;11(4):949-56
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(64)
Other
accession IDs
MGD-MRK-13821, MGD-MRK-13847, MGD-MRK-1478, MGD-MRK-1479, MGI:2140881

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory