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Atp6v0c Gene Detail
Summary
  • Symbol
    Atp6v0c
  • Name
    ATPase, H+ transporting, lysosomal V0 subunit C
  • Synonyms
    Atp6c2, Atp6l, Atpl, Atpl-rs1, H(+)-ATPase (mvp), PL16, proteolipid
  • Feature Type
    protein coding gene
  • IDs
    MGI:88116
    NCBI Gene: 11984
  • Gene Overview
    MyGene.info: ATP6V0C
Location & Maps
more
  • Sequence Map
    Chr17:24163866-24169702 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5837 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.29 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ATP6V0C, ATPase H+ transporting V0 subunit c
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ATP6V0C, ATPase H+ transporting V0 subunit c
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATP6C, ATP6L, ATPL, VATL, Vma3, VPPC
  • Links
    NCBI Gene ID: 527
    neXtProt AC: NX_P27449

  • Chr Location
    16p13.3; chr16:2513726-2520223 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    1
  • Targeted
    1
Homozygous mutation of this gene results in embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023843 VEGA Gene Model | MGI Sequence Detail 5837 C57BL/6J ±  kb
transcript OTTMUST00000058234 VEGA | MGI Sequence Detail 1183 Not Applicable  
polypeptide OTTMUSP00000028185 VEGA | MGI Sequence Detail 155 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    66 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000004475 V-type proton ATPase 16 kDa proteolipid subunit
  • InterPro Domains
    IPR000245 V-ATPase proteolipid subunit
    IPR011555 V-ATPase proteolipid subunit C, eukaryotic
    IPR002379 V-ATPase proteolipid subunit C-like domain
Molecular
Reagents
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  • All nucleic 31
    cDNA 28
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1476, MGD-MRK-36190, MGD-MRK-36468, MGI:107616
References
more
  • Summaries
    All 43
    Developmental Gene Expression 8
    Gene Ontology 7
    Phenotypes 2
  • Earliest
    J:20078 Hanada H, et al., Molecular cloning of cDNA encoding the 16 KDa subunit of vacuolar H(+)-ATPase from mouse cerebellum. Biochem Biophys Res Commun. 1991 May 15;176(3):1062-7
  • Latest
    J:213512 Werber M, et al., The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development. 2014 Jun;141(11):2325-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory