Atp4a
Gene Detail

Symbol Name ID

Atp4a ATPase, H+/K+ exchanging, gastric, alpha polypeptide MGI:88113

Synonyms

H+/K+-ATPase alpha, H+K+-transporting alpha 1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

19.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:30712209-30725535 bp, + strand From VEGA annotation of GRCm38   13327 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68081  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp4a

Human homologs

Human Homolog		ATP4A, ATPase, H+/K+ exchanging, alpha polypeptide
NCBI Gene ID		495
neXtProt AC		NX_P20648
Human Synonyms		ATP6A
Human Chr (Location)		19q13.1; chr19:36041095-36054560 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Chemically induced(1)
 

Homozygous mutation of this gene results in achlorhydria, hypergastrinemia, and abnormalities of the parietal cells. Mice homozygous for an ENU-induced allele exhibit iron-deficiency anemia.

 
Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	ATP biosynthetic process, ATP catabolic process, ...
Component	apical plasma membrane, integral to membrane, ...
Function	ATP binding, cation-transporting ATPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(10)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000036851 (Evidence)
Ensembl Gene Model	ENSMUSG00000005553 (Evidence)
Entrez Gene	11944 (Evidence)
UniGene	12821
DFCI	TC1584824, TC1596632
DoTS	DT.101366544, DT.60103722, DT.94328281
NIA Mouse Gene Index	U007940
EC	3.6.3.10
Consensus CDS Project	CCDS52182.1
International Mouse Knockout Project Status	Atp4a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036851	VEGA Gene Model | MGI Sequence Detail	13327	C57BL/6J
transcript	OTTMUST00000094638	VEGA | MGI Sequence Detail	3498	Not Applicable
polypeptide	OTTMUSP00000052677	VEGA | MGI Sequence Detail	1034	Not Applicable

All sequences(35) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(3) : SNPs(171 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023306	ATPase, cation-transporting, domain N
InterPro	IPR008250	ATPase, P-type, ATPase-associated domain
InterPro	IPR006069	ATPase, P-type cation exchange, alpha subunit
InterPro	IPR005775	ATPase, P-type cation exchange, alpha subunit, eukaryotic
InterPro	IPR006068	ATPase, P-type cation-transporter, C-terminal
InterPro	IPR004014	ATPase, P-type cation-transporter, N-terminal
InterPro	IPR023299	ATPase, P-type, cytoplasmic domain N
InterPro	IPR023300	ATPase, P-type, cytoplasmic transduction domain A
InterPro	IPR015127	ATPase, P-type, gastric H+/K+-transporter, N-terminal
InterPro	IPR001757	ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
InterPro	IPR018303	ATPase, P-type phosphorylation site
InterPro	IPR023298	ATPase, P-type, transmembrane domain
InterPro	IPR023214	HAD-like domain
InterPro	IPR005834	Haloacid dehalogenase-like hydrolase
Protein Ontology	PR:000004451	potassium-transporting ATPase alpha chain 1

References

(Earliest) J:12937 Sayed AK, et al., <64>Cu uptake by cultured fibroblasts from Mo
/Y mice. Fed Proc. 1978;37:746
(Latest) J:188007 Tu E, et al., Both IFN-gamma and IL-17 are required for the development of severe autoimmune gastritis. Eur J Immunol. 2012 Oct;42(10):2574-83
All references(56)

Other accession IDs

MGD-MRK-1466