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Atp4a
Gene Detail
 Symbol
Name
ID
Atp4a
ATPase, H+/K+ exchanging, gastric, alpha polypeptide
MGI:88113
Synonyms H+/K+-ATPase alpha, H+K+-transporting alpha 1
Feature Type protein coding gene
Genetic Map
Chromosome 7
19.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:30712209-30725535 bp, + strand
From VEGA annotation of GRCm38

  13327 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68081  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp4a

Human
homologs
Human Homolog ATP4A, ATPase, H+/K+ exchanging, alpha polypeptide
NCBI Gene ID 495
neXtProt AC  NX_P20648
Human Synonyms  ATP6A
Human Chr (Location)  19q13.1; chr19:35550193-35563658 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in achlorhydria, hypergastrinemia, and abnormalities of the parietal cells. Mice homozygous for an ENU-induced allele exhibit iron-deficiency anemia.
 
Phenotype Images(5)
Interactions
Atp4a interacts with 90 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process ATP biosynthetic process, ATP catabolic process, ...
Component apical plasma membrane, extracellular space, ...
Function ATP binding, cation-transporting ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036851 (Evidence)
Ensembl Gene ModelENSMUSG00000005553 (Evidence)
Entrez Gene11944 (Evidence)
UniGene12821
DFCITC1584824, TC1596632
DoTSDT.101366544, DT.60103722, DT.94328281
NIA Mouse Gene IndexU007940
EC3.6.3.10
Consensus CDS ProjectCCDS52182.1, CCDS71932.1
International Mouse Knockout Project StatusAtp4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036851 VEGA Gene Model | MGI Sequence Detail 13327 C57BL/6J ±  kb
transcript OTTMUST00000094638 VEGA | MGI Sequence Detail 3498 Not Applicable 
polypeptide OTTMUSP00000052677 VEGA | MGI Sequence Detail 1034 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(5) UniProt(4)
Polymorphisms RFLP(3) : SNPs within 2kb(260 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR015127 Gastric H+/K+-transporter P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
InterPro IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
Protein Ontology PR:000004451 potassium-transporting ATPase alpha chain 1
References (Earliest) J:12937 Sayed AK, et al., <64>Cu uptake by cultured fibroblasts from Mo
/Y mice. Fed Proc. 1978;37:746
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(59)
Other
accession IDs
MGD-MRK-1466

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory