Atp2b4
Gene Detail

Symbol Name ID

Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 MGI:88111

Synonyms

PMCA4

Feature Type

protein coding gene

Genetic Map

Chromosome 1

57.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:133702678-133801041 bp, - strand From VEGA annotation of GRCm38   98364 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48034  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2b4

Human homologs

Human Homolog		ATP2B4, ATPase, Ca++ transporting, plasma membrane 4
NCBI Gene ID		493
neXtProt AC		NX_P23634
Human Synonyms		ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x
Human Chr (Location)		1q32.1; chr1:203595915-203713209 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(4) Gene trapped(4)
 

Homozygous null mice display male infertility with impaired sperm motility.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	calcium ion export, calcium ion transmembrane transport, ...
Component	basolateral plasma membrane, integral to membrane, ...
Function	ATP binding, calcium-transporting ATPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (127)    Tissues (97)    Images (23)
Theiler Stages: 15, 22, 23

Assay Type	Results
RNA in situ	122
Western blot	5

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(7)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016442 (Evidence)
Ensembl Gene Model	ENSMUSG00000026463 (Evidence)
Entrez Gene	381290 (Evidence)
DFCI	TC1649119, TC1674234, TC1690327
DoTS	DT.101368752, DT.40142197, DT.87028127, DT.94130139
NIA Mouse Gene Index	U134130
Consensus CDS Project	CCDS15298.1, CCDS48365.1
International Mouse Knockout Project Status	Atp2b4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016442	VEGA Gene Model | MGI Sequence Detail	98364	C57BL/6J
transcript	OTTMUST00000039594	VEGA | MGI Sequence Detail	8504	Not Applicable
polypeptide	OTTMUSP00000017683	VEGA | MGI Sequence Detail	1205	Not Applicable

All sequences(57) RefSeq(4) UniProt(9)

Polymorphisms

SNPs(140 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008250	ATPase, P-type, ATPase-associated domain
InterPro	IPR006408	ATPase, P-type, calcium-transporting, PMCA-type
InterPro	IPR006069	ATPase, P-type cation exchange, alpha subunit
InterPro	IPR006068	ATPase, P-type cation-transporter, C-terminal
InterPro	IPR004014	ATPase, P-type cation-transporter, N-terminal
InterPro	IPR023299	ATPase, P-type, cytoplasmic domain N
InterPro	IPR023300	ATPase, P-type, cytoplasmic transduction domain A
InterPro	IPR001757	ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
InterPro	IPR018303	ATPase, P-type phosphorylation site
InterPro	IPR023298	ATPase, P-type, transmembrane domain
InterPro	IPR023214	HAD-like domain
InterPro	IPR005834	Haloacid dehalogenase-like hydrolase
InterPro	IPR022141	Plasma membrane calcium transporter ATPase C-terminal
Protein Ontology	PR:000004448	plasma membrane calcium-transporting ATPase 4

References

(Earliest) J:16146 Hunter KW, et al., Single-strand conformational polymorphism (SSCP) mapping of the mouse genome: integration of the SSCP, microsatellite, and gene maps of mouse chromosome 1. Genomics. 1993 Dec;18(3):510-9
(Latest) J:194387 Kim HJ, et al., Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival. J Cell Biol. 2012 Dec 24;199(7):1145-58
All references(45)

Other accession IDs

MGD-MRK-1464