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Atp1b2
Gene Detail
Symbol

Name
ID
Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
MGI:88109
STS
Synonyms
Amog, Atpb-2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr11:69599736-69605942 bp, - strand
From VEGA annotation of GRCm38

  6207 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ATP1B2
Gene Tree: Atp1b2

Human
homologs
ATP1B2, ATPase, Na+/K+ transporting, beta 2 polypeptide
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 482
neXtProt AC: NX_P14415

Human Synonyms: AMOG

Human Chr (Location): 17p13.1; chr17:7646627-7657771 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Genomic Mutations involving Atp1b2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a null mutation exhibit lack of motor coordination, tremors, limb paralysis, enlarged ventricles, photoreceptor degeneration, vacuoles adjoining capillaries of brain stem, thalamus, striatum, and spinal cord, and death at 17-18 days of age.
 
Interactions
Atp1b2 interacts with 256 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell adhesion, cellular potassium ion homeostasis, ...
Component apical plasma membrane, cytoplasm, ...
Function ATPase activator activity, ATPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (214)    Tissues (128)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 177
Northern blot 10
Western blot 14
RT-PCR 9
cDNA source data(66)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase atp1b2 ; ZFIN atp1b2a    NEW 
Molecular
reagents
All nucleic(80) Genomic(6) cDNA(69) Primer pair(4) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000005985 (Evidence)
Ensembl Gene Model ENSMUSG00000041329 (Evidence)
Entrez Gene 11932 (Evidence)
UniGene 235204
DFCI TC1579232, TC1603662, TC1693501
DoTS DT.101191262, DT.529847
NIA Mouse Gene Index U032969
Consensus CDS Project CCDS24898.1
International Mouse Phenotyping Consortium Status Atp1b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005985 VEGA Gene Model | MGI Sequence Detail 6207 C57BL/6J ±  kb
transcript OTTMUST00000013391 VEGA | MGI Sequence Detail 2842 Not Applicable 
polypeptide OTTMUSP00000006200 VEGA | MGI Sequence Detail 290 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(5) : PCR(3) RFLP(2) SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000402 Sodium/potassium-transporting ATPase subunit beta
Protein Ontology PR:000004440 sodium/potassium-transporting ATPase subunit beta-2
References
(Earliest) J:9735 Pagliusi S, et al., Identification of a cDNA clone specific for the neural cell adhesion molecule AMOG [published erratum appears in J Neurosci Res 1989 Dec;24(4):567]. J Neurosci Res. 1989 Feb;22(2):113-9
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(65)
Other
accession IDs
MGD-MRK-1306, MGD-MRK-1461, MGD-MRK-1475

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory