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Atp1a1 Gene Detail
Summary
  • Symbol
    Atp1a1
  • Name
    ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Synonyms
    Atpa-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88105
    NCBI Gene: 11928
Location & Maps
more
  • Sequence Map
    Chr3:101576219-101604684 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28466 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ATP1A1, ATPase Na+/K+ transporting subunit alpha 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    ATP1A1, ATPase Na+/K+ transporting subunit alpha 1
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 476
    neXtProt AC: NX_P05023

  • Chr Location
    1p21; chr1:116372185-116404774 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Chemically induced (other)
    1
  • Gene trapped
    19
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Atp1a1
  • Incidental Mutations
Mice homozygous for disruptions in this gene have a lethal phenotype. Heterozygotes display increased anxiety and decreased exploratory behavior in a new environment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016447 VEGA Gene Model | MGI Sequence Detail 28466 C57BL/6J ±  kb
transcript OTTMUST00000039619 VEGA | MGI Sequence Detail 3679 Not Applicable  
polypeptide OTTMUSP00000017686 VEGA | MGI Sequence Detail 1023 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    175 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 744
    Genomic 4
    cDNA 738
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-1457, MGD-MRK-1470, MGI:2387620
References
more
  • Summaries
    All 121
    Developmental Gene Expression 40
    Gene Ontology 21
    Phenotypes 29
  • Earliest
    J:7397 Levenson R, et al., Molecular cloning of the mouse ouabain-resistance gene. Proc Natl Acad Sci U S A. 1984 Mar;81(5):1489-93
  • Latest
    J:227218 Sharma P, et al., Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun. 2015;6:8391

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory