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Atp1a1
Gene Detail
 Symbol
Name
ID
Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
MGI:88105
Synonyms Atpa-1
Feature Type protein coding gene
Genetic Map
Chromosome 3
44.30 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr3:101576219-101604603 bp, - strand
From VEGA annotation of GRCm38

  28385 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:564  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp1a1

Human
homologs
Human Homolog ATP1A1, ATPase, Na+/K+ transporting, alpha 1 polypeptide
NCBI Gene ID 476
neXtProt AC  NX_P05023
Human Chr (Location)  1p21; chr1:116372180-116404774 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(21) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have a lethal phenotype. Heterozygotes display increased anxiety and decreased exploratory behavior in a new environment.
 
Interactions
Atp1a1 interacts with 94 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process ATP biosynthetic process, ATP catabolic process, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function ADP binding, ankyrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (200)    Tissues (157)    Images (31)
Theiler Stages: 3, 4, 16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 139
Northern blot 28
Western blot 19
RT-PCR 2
cDNA source data(732)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(744) Genomic(4) cDNA(738) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016447 (Evidence)
Ensembl Gene ModelENSMUSG00000033161 (Evidence)
Entrez Gene11928 (Evidence)
UniGene280103
DFCITC1573729, TC1706001, TC1751293
DoTSDT.101183734, DT.101239863, DT.101368510, DT.496244, DT.94145409, DT.94145416, DT.94146579, DT.94202066, DT.99872006
NIA Mouse Gene IndexU024436
EC3.6.1.37, 3.6.3.9
Consensus CDS ProjectCCDS17683.1
International Mouse Knockout Project StatusAtp1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016447 VEGA Gene Model | MGI Sequence Detail 28385 C57BL/6J ±  kb
transcript OTTMUST00000039619 VEGA | MGI Sequence Detail 3598 Not Applicable 
polypeptide OTTMUSP00000017686 VEGA | MGI Sequence Detail 1023 Not Applicable 

For the selected sequences
All sequences(149) RefSeq(2) UniProt(6)
Polymorphisms RFLP(3) : SNPs within 2kb(175 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
InterPro IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
Protein Ontology PR:000004435 sodium/potassium-transporting ATPase subunit alpha-1
References (Earliest) J:7397 Levenson R, et al., Molecular cloning of the mouse ouabain-resistance gene. Proc Natl Acad Sci U S A. 1984 Mar;81(5):1489-93
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(117)
Other
accession IDs
MGD-MRK-1457, MGD-MRK-1470, MGI:2387620

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory