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Atp1a1
Gene Detail
Symbol

Name
ID
Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
MGI:88105
Synonyms
Atpa-1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
44.30 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr3:101576219-101604603 bp, - strand
From VEGA annotation of GRCm38

  28385 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:564  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: ATP1A1
Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp1a1

Human
homologs
ATP1A1, ATPase, Na+/K+ transporting, alpha 1 polypeptide
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 476
neXtProt AC: NX_P05023

Human Chr (Location): 1p21; chr1:116372185-116404774 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(21) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene have a lethal phenotype. Heterozygotes display increased anxiety and decreased exploratory behavior in a new environment.
 
Interactions
Atp1a1 interacts with 93 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (79 annotations)
Process cellular potassium ion homeostasis, cellular response to mechanical stimulus, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function ADP binding, ankyrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (208)    Tissues (165)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 20
RNA in situ 139
Northern blot 28
Western blot 19
RT-PCR 2
cDNA source data(732)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA ATP1A1 ; Xenbase atp1a1 ; ZFIN atp1a1a.1, atp1a1a.2, atp1a1a.3, atp1a1a.4, atp1a1a.5, atp1a1b    NEW 
Molecular
reagents
All nucleic(744) Genomic(4) cDNA(738) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016447 (Evidence)
Ensembl Gene Model ENSMUSG00000033161 (Evidence)
Entrez Gene 11928 (Evidence)
UniGene 280103
DFCI TC1573729, TC1706001, TC1751293
DoTS DT.101183734, DT.101239863, DT.101368510, DT.496244, DT.94145409, DT.94145416, DT.94146579, DT.94202066, DT.99872006
NIA Mouse Gene Index U024436
EC 3.6.1.37, 3.6.3.9
Consensus CDS Project CCDS17683.1
International Mouse Phenotyping Consortium Status Atp1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016447 VEGA Gene Model | MGI Sequence Detail 28385 C57BL/6J ±  kb
transcript OTTMUST00000039619 VEGA | MGI Sequence Detail 3598 Not Applicable 
polypeptide OTTMUSP00000017686 VEGA | MGI Sequence Detail 1023 Not Applicable 

For the selected sequences
All sequences(155) RefSeq(2) UniProt(6)
Polymorphisms
RFLP(3) : SNPs within 2kb(175 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
InterPro IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
Protein Ontology PR:000004435 sodium/potassium-transporting ATPase subunit alpha-1
References
(Earliest) J:7397 Levenson R, et al., Molecular cloning of the mouse ouabain-resistance gene. Proc Natl Acad Sci U S A. 1984 Mar;81(5):1489-93
(Latest) J:214760 Moreau JL, et al., Cited2 is required in trophoblasts for correct placental capillary patterning. Dev Biol. 2014 Aug 1;392(1):62-79
All references(119)
Other
accession IDs
MGD-MRK-1457, MGD-MRK-1470, MGI:2387620

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory