Atp1a1
Gene Detail

Symbol Name ID

Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide MGI:88105

Synonyms

Atpa-1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

44.30 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr3:101576219-101604603 bp, - strand From VEGA annotation of GRCm38   28385 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; pig, domestic; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Atp1a1 ± 2 cM)

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp1a1

Human ortholog

ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide NCBI Gene ID 476
Human Chr1:116915795-116947396 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(24) : Targeted(3) Gene trapped(21)
 

Mice homozygous for disruptions in this gene have a lethal phenotype. Heterozygotes display increased anxiety and decreased exploratory behavior in a new environment.

 

Gene Ontology (GO) classifications

All GO classifications: (60 annotations)

Process	ATP biosynthetic process, ATP catabolic process, ...
Component	basolateral plasma membrane, caveola, ...
Function	4-nitrophenylphosphatase activity, ADP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (30 records)
Data Summary: Results (188)    Tissues (145)    Images (30)
Theiler Stages: 3, 4, 5, 16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	127
Northern blot	28
Western blot	19
RT-PCR	2

cDNA source data(734)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(746) Genomic(4) cDNA(740) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016447 (Evidence)
Ensembl Gene Model	ENSMUSG00000033161 (Evidence)
Entrez Gene	11928 (Evidence)
UniGene	280103
DFCI	TC1573729, TC1706001, TC1751293
DoTS	DT.101183734, DT.101239863, DT.101368510, DT.496244, DT.94145409, DT.94145416, DT.94146579, DT.94202066, DT.99872006
NIA Mouse Gene Index	U024436
EC	3.6.1.37, 3.6.3.9
Consensus CDS Project	CCDS17683.1
International Mouse Knockout Project Status	Atp1a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016447	VEGA Gene Model | MGI Sequence Detail	28385	C57BL/6J
transcript	OTTMUST00000039619	VEGA | MGI Sequence Detail	3598	Not Applicable
polypeptide	OTTMUSP00000017686	VEGA | MGI Sequence Detail	1023	Not Applicable

All sequences(149) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(3) : SNPs(141 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023306	ATPase, cation-transporting, domain N
InterPro	IPR008250	ATPase, P-type, ATPase-associated domain
InterPro	IPR006069	ATPase, P-type cation exchange, alpha subunit
InterPro	IPR005775	ATPase, P-type cation exchange, alpha subunit, eukaryotic
InterPro	IPR006068	ATPase, P-type cation-transporter, C-terminal
InterPro	IPR004014	ATPase, P-type cation-transporter, N-terminal
InterPro	IPR023299	ATPase, P-type, cytoplasmic domain N
InterPro	IPR023300	ATPase, P-type, cytoplasmic transduction domain A
InterPro	IPR001757	ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
InterPro	IPR018303	ATPase, P-type phosphorylation site
InterPro	IPR023298	ATPase, P-type, transmembrane domain
InterPro	IPR023214	HAD-like domain
InterPro	IPR005834	Haloacid dehalogenase-like hydrolase
Protein Ontology	PR:000004435	sodium/potassium-transporting ATPase subunit alpha-1

References

(Earliest) J:7397 Levenson R, et al., Molecular cloning of the mouse ouabain-resistance gene. Proc Natl Acad Sci U S A. 1984 Mar;81(5):1489-93
(Latest) J:192981 Tokhtaeva E, et al., Subunit isoform selectivity in assembly of Na,K-ATPase alpha-beta heterodimers. J Biol Chem. 2012 Jul 27;287(31):26115-25
All references(108)

Other accession IDs

MGD-MRK-1457, MGD-MRK-1470, MGI:2387620