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Atp1a1 Gene Detail
Summary
  • Symbol
    Atp1a1
  • Name
    ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Synonyms
    Atpa-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88105
    NCBI Gene: 11928
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:101576219-101604684 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28466 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 44.30 cM, cytoband F3
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    ATP1A1, ATPase Na+/K+ transporting subunit alpha 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    ATP1A1, ATPase Na+/K+ transporting subunit alpha 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMT2DD
  • Links
    NCBI Gene ID: 476
    neXtProt AC: NX_P05023
    UniProt: P05023

  • Chr Location
    1p13.1; chr1:116373173-116404774 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a lethal phenotype. Heterozygotes display increased anxiety and decreased exploratory behavior in a new environment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016447 VEGA Gene Model | MGI Sequence Detail 28466 C57BL/6J ±  kb
    transcript OTTMUST00000039619 VEGA | MGI Sequence Detail 3679 Not Applicable  
    polypeptide OTTMUSP00000017686 VEGA | MGI Sequence Detail 1023 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      175 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 746
      Genomic 4
      cDNA 739
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1457, MGD-MRK-1470, MGI:2387620
    References
    more
    • Summaries
      All 143
      Developmental Gene Expression 48
      Diseases 1
      Gene Ontology 21
      Phenotypes 31
    • Earliest
      J:7397 Levenson R, et al., Molecular cloning of the mouse ouabain-resistance gene. Proc Natl Acad Sci U S A. 1984 Mar;81(5):1489-93
    • Latest
      J:251823 Takagishi M, et al., Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus. Cell Rep. 2017 Jul 25;20(4):960-972

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory