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Serpinc1
Gene Detail
 Symbol
Name
ID
Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
MGI:88095
Synonyms antithrombin, At3, At-3, ATIII
Feature Type protein coding gene
Genetic Map
Chromosome 1
69.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
Chr1:160978606-161003010 bp, + strand
From Ensembl annotation of GRCm38

  24405 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpinc1

Human
homologs
Human Homolog SERPINC1, serpin peptidase inhibitor, clade C (antithrombin), member 1
NCBI Gene ID 462
neXtProt AC  NX_P01008
Human Synonyms  AT3, AT3D, ATIII, THPH7
Human Chr (Location)  1q25.1; chr1:173903800-173917378 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SERPINC1
Alleles
and
phenotypes
All alleles(12) : Targeted(4) Gene trapped(8)
 
Homozygotes for a targeted null mutation exhibit extensive subcutaneous hemorrhage, fibrin deposits in the myocardium and liver, and lethality by embryonic day 16.5. Heterozygotes challenged with lipopolysaccharide show increased fibrin deposits.
 
Human Diseases Modeled Using Mouse Serpinc1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process blood coagulation, hemostasis, ...
Component blood microparticle, extracellular region, ...
Function heparin binding, peptidase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (36)    Tissues (13)    Images (23)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 22
Western blot 2
RT-PCR 12
cDNA source data(220)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(223) cDNA(221) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026715 (Evidence)
Entrez Gene11905 (Evidence)
UniGene260770
DFCITC1574302
DoTSDT.101246135, DT.40138328
NIA Mouse Gene IndexU000990
Consensus CDS ProjectCCDS15411.1
International Mouse Knockout Project StatusSerpinc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026715 Ensembl Gene Model | MGI Sequence Detail 24405 C57BL/6J ±  kb
transcript ENSMUST00000064725 Ensembl | MGI Sequence Detail 2157 Not Applicable 
polypeptide ENSMUSP00000068971 Ensembl | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(2)
Polymorphisms RFLP(3) : SNPs within 2kb(255 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015555 Antithrombin-III
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000003252 antithrombin-III
References (Earliest) J:9067 Seldin MF, et al., Genetic analysis of autoimmune gld mice. I. Identification of a restriction fragment length polymorphism closely linked to the gld mutation within a conserved linkage group. J Exp Med. 1988 Feb 1;167(2):688-93
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(77)
Other
accession IDs
MGD-MRK-1442, MGD-MRK-1443, MGI:2138155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory