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Serpinc1
Gene Detail
Symbol

Name
ID
Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
MGI:88095
Synonyms
antithrombin, At3, At-3, ATIII
Feature Type
protein coding gene
Genetic Map
Chromosome 1
69.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
Chr1:160978585-161005863 bp, + strand
From VEGA annotation of GRCm38

  27279 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SERPINC1
Protein SuperFamily: serpin
Gene Tree: Serpinc1

Human
homologs
SERPINC1, serpin peptidase inhibitor, clade C (antithrombin), member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 462
neXtProt AC: NX_P01008

Human Synonyms: AT3, AT3D, ATIII, THPH7

Human Chr (Location): 1q25.1; chr1:173903800-173917378 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SERPINC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(9) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit extensive subcutaneous hemorrhage, fibrin deposits in the myocardium and liver, and lethality by embryonic day 16.5. Heterozygotes challenged with lipopolysaccharide show increased fibrin deposits.
 
Human Diseases Modeled in Mice Using Serpinc1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Serpinc1 interacts with 95 markers (Mir26a-1, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process blood coagulation, hemostasis, ...
Component blood microparticle, extracellular exosome, ...
Function heparin binding, peptidase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (36)    Tissues (13)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 22
Western blot 2
RT-PCR 12
cDNA source data(220)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase serpinc1 ; ZFIN serpinc1    NEW 
Molecular
reagents
All nucleic(223) cDNA(221) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000050830 (Evidence)
Ensembl Gene Model ENSMUSG00000026715 (Evidence)
Entrez Gene 11905 (Evidence)
UniGene 260770
DFCI TC1574302
DoTS DT.101246135, DT.40138328
NIA Mouse Gene Index U000990
Consensus CDS Project CCDS15411.1
International Mouse Phenotyping Consortium Status Serpinc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050830 VEGA Gene Model | MGI Sequence Detail 27279 C57BL/6J ±  kb
transcript OTTMUST00000128793 VEGA | MGI Sequence Detail 4970 Not Applicable 
polypeptide OTTMUSP00000069264 VEGA | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(6) UniProt(7)
Polymorphisms
RFLP(3) : SNPs within 2kb(271 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015555 Antithrombin-III
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000003252 antithrombin-III
References
(Earliest) J:9067 Seldin MF, et al., Genetic analysis of autoimmune gld mice. I. Identification of a restriction fragment length polymorphism closely linked to the gld mutation within a conserved linkage group. J Exp Med. 1988 Feb 1;167(2):688-93
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(71)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1442, MGD-MRK-1443, MGI:2138155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory