Serpinc1
Gene Detail

Symbol Name ID

Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 MGI:88095

Synonyms

antithrombin, At3, At-3, ATIII

Feature Type

protein coding gene

Genetic Map

Chromosome 1

69.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)

Sequence Map

Chr1:160978606-161003010 bp, + strand From Ensembl annotation of GRCm38   24405 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; hamster, golden; horse    (Mammalian Orthology)
Comparative Map (Mouse/Human Serpinc1 ± 2 cM)

Protein SuperFamily: serpin
Gene Tree: Serpinc1

Human ortholog

SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 NCBI Gene ID 462
Human Synonyms: AT3, AT3D, ATIII, THPH7
Human Chr1:173872942-173886516 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human SERPINC1 (1)

Alleles and phenotypes

All alleles(12) : Targeted(4) Gene trapped(8)
 

Homozygotes for a targeted null mutation exhibit extensive subcutaneous hemorrhage, fibrin deposits in the myocardium and liver, and lethality by embryonic day 16.5. Heterozygotes challenged with lipopolysaccharide show increased fibrin deposits.

 
Human Diseases Modeled Using Mouse Serpinc1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	blood coagulation, hemostasis, ...
Component	extracellular region, extracellular space
Function	heparin binding, peptidase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (36)    Tissues (13)    Images (23)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	22
Western blot	2
RT-PCR	12

cDNA source data(220)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(223) cDNA(221) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000026715 (Evidence)
Entrez Gene	11905 (Evidence)
UniGene	260770
DFCI	TC1574302
DoTS	DT.101246135, DT.40138328
NIA Mouse Gene Index	U000990
Consensus CDS Project	CCDS15411.1
International Mouse Knockout Project Status	Serpinc1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000026715	Ensembl Gene Model | MGI Sequence Detail	24405	C57BL/6J
transcript	ENSMUST00000064725	Ensembl | MGI Sequence Detail	2157	Not Applicable
polypeptide	ENSMUSP00000068971	Ensembl | MGI Sequence Detail	465	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(3) : SNPs(71 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015555	Antithrombin-III
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000003252	antithrombin-III

References

(Earliest) J:9067 Seldin MF, et al., Genetic analysis of autoimmune gld mice. I. Identification of a restriction fragment length polymorphism closely linked to the gld mutation within a conserved linkage group. J Exp Med. 1988 Feb 1;167(2):688-93
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(76)

Other accession IDs

MGD-MRK-1442, MGD-MRK-1443, MGI:2138155