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Asgr2
Gene Detail
Symbol

Name
ID
Asgr2
asialoglycoprotein receptor 2
MGI:88082
Synonyms
ASGPR2, Asgr, Asgr-2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:70092644-70106187 bp, + strand
From VEGA annotation of GRCm38

  13544 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:912  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: ASGR2
Protein SuperFamily: asialoglycoprotein receptor 1-like protein
Gene Tree: Asgr2

Human
homologs
ASGR2, asialoglycoprotein receptor 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 433
neXtProt AC: NX_P07307

Human Synonyms: ASGPR2, ASGP-R2, CLEC4H2, HBXBP, HL-2

Human Chr (Location): 17p; chr17:7101322-7115522 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Genomic Mutations involving Asgr2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in reduced ASGR1 protein expression and deficiency in clearance of asialoorsomucoid.
 
Interactions
Asgr2 interacts with 46 markers (Mir26a-1, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process endocytosis, glycoprotein metabolic process, ...
Component integral component of membrane, membrane
Function carbohydrate binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006018 (Evidence)
Ensembl Gene Model ENSMUSG00000040963 (Evidence)
Entrez Gene 11890 (Evidence)
UniGene 1357
DFCI TC1587285
DoTS DT.60102075
NIA Mouse Gene Index U012844
Consensus CDS Project CCDS24934.1
International Mouse Phenotyping Consortium Status Asgr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006018 VEGA Gene Model | MGI Sequence Detail 13544 C57BL/6J ±  kb
transcript OTTMUST00000013491 VEGA | MGI Sequence Detail 1373 Not Applicable 
polypeptide OTTMUSP00000006251 VEGA | MGI Sequence Detail 301 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(196 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR005640 Hepatic lectin, N-terminal
Protein Ontology PR:000004370 asialoglycoprotein receptor 2
References
(Earliest) J:9658 Sanford JP, et al., Asialoglycoprotein receptor genes are linked on chromosome 11 in the mouse. DNA. 1988 Dec;7(10):721-8
(Latest) J:181586 Hald J, et al., Pancreatic islet and progenitor cell surface markers with cell sorting potential. Diabetologia. 2012 Jan;55(1):154-65
All references(35)
Other
accession IDs
MGD-MRK-1414, MGD-MRK-1416, MGD-MRK-1418

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory