Asgr2 MGI Mouse Gene Detail - MGI:88082 - asialoglycoprotein receptor 2

Symbol

Asgr2
Name

asialoglycoprotein receptor 2
Synonyms

ASGPR2, Asgr, Asgr-2

Feature Type

protein coding gene
IDs

MGI:88082
NCBI Gene: 11890
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:69983470-69997013 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.99 cM
Mapping Data

5 experiments

SNPs within 2kb

211 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88082	protein coding gene	Chr11:69983470-69997013 (+)
129S1/SvImJ	ENSMUSG00200041808	protein coding gene	Chr11:66930452-66943983 (+)
A/J	ENSMUSG00195051462	protein coding gene	Chr11:66956949-66970492 (+)
AKR/J	ENSMUSG00220054120	protein coding gene	Chr11:67065895-67079422 (+)
BALB/cJ	ENSMUSG00180037372	protein coding gene	Chr11:67025492-67039023 (+)
C3H/HeJ	ENSMUSG00175053177	protein coding gene	Chr11:66975707-66989238 (+)
C57BL/6NJ	ENSMUSG00215053031	protein coding gene	Chr11:66752854-66766399 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016617	protein coding gene	Chr11:64849558-64864563 (+)
CAST/EiJ	ENSTCUG00005047976	protein coding gene	Chr11:66519008-66532960 (+)
CBA/J	ENSMUSG00210054300	protein coding gene	Chr11:66829747-66843278 (+)
DBA/2J	ENSMUSG00185053740	protein coding gene	Chr11:67032018-67045964 (+)
FVB/NJ	ENSMUSG00205030194	protein coding gene	Chr11:66928151-66941696 (+)
JF1/MsJ	ENSUMUG00000056610	protein coding gene	Chr11:67430499-67444448 (+)
LP/J	ENSMUSG00230053235	protein coding gene	Chr11:68140788-68154319 (+)
NOD/ShiLtJ	ENSMUSG00190030105	protein coding gene	Chr11:67059683-67073214 (+)
NZO/HlLtJ	ENSMUSG00225043951	protein coding gene	Chr11:70322236-70335767 (+)
PWK/PhJ	ENSLUMG00010053397	protein coding gene	Chr11:66945629-66959154 (+)
SPRET/EiJ	ENSMSPG00010048656	protein coding gene	Chr11:67670716-67684465 (+)
WSB/EiJ	ENSIUOG00005048528	protein coding gene	Chr11:66960931-66974495 (+)

Human Ortholog

ASGR2, asialoglycoprotein receptor 2

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASGR2, asialoglycoprotein receptor 2
Synonyms

ASGP-R2, ASGPR2, CLEC4H2, HBXBP, HL-2
Links

HGNC:743

NCBI Gene ID: 433

UniProt: P07307
Chr Location

17p13.1; chr17:7100166-7116603 (-) GRCh38

MGI Vertebrate Homology

Asgr2 stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: ASGR2
Gene Tree

Asgr2

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Phenotype Summary

4 phenotypes from 1 allele in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

3
Transgenic

1
Genomic Mutations

3 involving Asgr2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in reduced ASGR1 protein expression and deficiency in clearance of asialoorsomucoid.

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

599
Tissues

2
cDNA Data

26
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN asgr1a

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All Sequences

42
RefSeq

8
UniProt

3
CCDS

CCDS24934.1

Ensembl

ENSMUSG00000040963 (Evidence)
NCBI Gene

11890

			Length	Strain/Species	Flank
genomic	11890	NCBI Gene Model \| MGI Sequence Detail	13544	C57BL/6J	± kb
transcript	NM_001313925	RefSeq \| MGI Sequence Detail	1446	ZRU/MplStud
polypeptide	P24721	UniProt \| EBI \| MGI Sequence Detail	301	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004370 asialoglycoprotein receptor 2

(term hierarchy)
InterPro Domains

IPR033989 CD209-like, C-type lectin-like domain

IPR050828 C-type lectin and matrix domain-containing protein

IPR050111 C-type lectin and snaclec domain-containing protein

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily
GlyGen

P24721 3 sites

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All nucleic 28

cDNA 27

Primer pair 1

Microarray probesets 3

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MGD-MRK-1414, MGD-MRK-1416, MGD-MRK-1418

Summaries

All 56

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 25
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Asgr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102652	Chr11:69983460-69983469 (+)	-5 bp
Tssr102653	Chr11:69983472-69983477 (+)	5 bp
Tssr102654	Chr11:69983479-69983524 (+)	32 bp
Tssr102655	Chr11:69983531-69983575 (+)	83 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24