Asgr1 MGI Mouse Gene Detail - MGI:88081 - asialoglycoprotein receptor 1

Symbol

Asgr1
Name

asialoglycoprotein receptor 1
Synonyms

ASGPR1, Asgr, Asgr-1

Feature Type

protein coding gene
IDs

MGI:88081
NCBI Gene: 11889
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:69944911-69948720 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.98 cM
Mapping Data

10 experiments

SNPs within 2kb

41 from dbSNP Build 142
Strain Annotations

19
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88081	protein coding gene	Chr11:69939735-69948721 (+)
129S1/SvImJ	ENSMUSG00200049336	protein coding gene	Chr11:66891899-66895707 (+)
A/J	ENSMUSG00195050795	protein coding gene	Chr11:66918373-66922183 (+)
AKR/J	ENSMUSG00220054109	protein coding gene	Chr11:67027370-67031177 (+)
BALB/cJ	ENSMUSG00180044213	protein coding gene	Chr11:66986929-66990739 (+)
C3H/HeJ	ENSMUSG00175054347	protein coding gene	Chr11:66937135-66940945 (+)
C57BL/6NJ	ENSMUSG00215052514	protein coding gene	Chr11:66714286-66718096 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016616	protein coding gene	Chr11:64802990-64806778 (+)
CAST/EiJ	ENSTCUG00005053262	protein coding gene	Chr11:66479774-66483603 (+)
CBA/J	ENSMUSG00210054294	protein coding gene	Chr11:66791194-66795002 (+)
DBA/2J	ENSMUSG00185053238	protein coding gene	Chr11:66993209-66997014 (+)
FVB/NJ	ENSMUSG00205027079	protein coding gene	Chr11:66884832-66888652 (+)
JF1/MsJ	ENSUMUG00000051591	protein coding gene	Chr11:67391652-67395457 (+)
LP/J	ENSMUSG00230052975	protein coding gene	Chr11:68102237-68106045 (+)
NOD/ShiLtJ	ENSMUSG00190029482	protein coding gene	Chr11:67021123-67024932 (+)
NZO/HlLtJ	ENSMUSG00225042658	protein coding gene	Chr11:70283684-70287492 (+)
PWK/PhJ	ENSLUMG00010053317	protein coding gene	Chr11:66907024-66910835 (+)
SPRET/EiJ	ENSMSPG00010048233	protein coding gene	Chr11:67635467-67639215 (+)
WSB/EiJ	ENSIUOG00005047359	protein coding gene	Chr11:66922372-66926196 (+)

Human Ortholog

ASGR1, asialoglycoprotein receptor 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASGR1, asialoglycoprotein receptor 1
Synonyms

ASGPR, ASGPR1, CLEC4H1, HL-1
Links

HGNC:742

NCBI Gene ID: 432

UniProt: P07306
Chr Location

17p13.1; chr17:7172535-7179648 (-) GRCh38

MGI Vertebrate Homology

Asgr1 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: ASGR1
Gene Tree

Asgr1

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

6
Transgenic

1
Genomic Mutations

3 involving Asgr1
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in impaired hepatic clearance of asialoglycoproteins.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

614
Tissues

11
cDNA Data

49
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase asgr1

ZFIN asgr1a

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All Sequences

52
RefSeq

10
UniProt

3
CCDS

CCDS24933.1, CCDS70224.1

Ensembl

ENSMUSG00000020884 (Evidence)
NCBI Gene

11889

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020884	Ensembl Gene Model \| MGI Sequence Detail	3810	C57BL/6J	± kb
transcript	ENSMUST00000146411	Ensembl \| MGI Sequence Detail	1188	Not Applicable
polypeptide	ENSMUSP00000121842	Ensembl \| MGI Sequence Detail	284	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004369 asialoglycoprotein receptor 1

(term hierarchy)
InterPro Domains

IPR033989 CD209-like, C-type lectin-like domain

IPR050111 C-type lectin and snaclec domain-containing protein

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily
GlyGen

P34927 4 sites

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All nucleic 52

cDNA 50

Primer pair 2

Microarray probesets 3

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MGD-MRK-1414, MGD-MRK-1415, MGD-MRK-1417

Summaries

All 81

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 32
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:364328 Zhang Y, et al., ASGR1 Deficiency Inhibits Atherosclerosis in Western Diet-Fed ApoE(-/-) Mice by Regulating Lipoprotein Metabolism and Promoting Cholesterol Efflux. Arterioscler Thromb Vasc Biol. 2024 Dec;44(12):2428-2449

TSS for Asgr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102647	Chr11:69945160-69945186 (+)	262 bp
Tssr102648	Chr11:69945188-69945203 (+)	285 bp
Tssr102649	Chr11:69945211-69945292 (+)	341 bp
Tssr102650	Chr11:69946894-69946910 (+)	1,991 bp
Tssr102651	Chr11:69947680-69947721 (+)	2,790 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29