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Asgr1
Gene Detail
 Symbol
Name
ID
Asgr1
asialoglycoprotein receptor 1
MGI:88081
Synonyms ASGPR1, Asgr, Asgr-1
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr11:70054085-70057894 bp, + strand
From VEGA annotation of GRCm38

  3810 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1263  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: asialoglycoprotein receptor 1-like protein
Gene Tree: Asgr1

Human
homologs
Human Homolog ASGR1, asialoglycoprotein receptor 1
NCBI Gene ID 432
neXtProt AC  NX_P07306
Human Synonyms  ASGPR, ASGPR1, CLEC4H1, HL-1
Human Chr (Location)  17p13.2; chr17:7173431-7179564 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
 
Homozygous mutation of this gene results in impaired hepatic clearance of asialoglycoproteins.
 
Interactions
Asgr1 interacts with 35 markers (Mir22, Mir29a, Mir29c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cellular response to extracellular stimulus, endocytosis, ...
Component integral component of membrane, membrane
Function asialoglycoprotein receptor activity, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (8)    Images (1)
Theiler Stages: 28
Assay TypeResults
RT-PCR 8
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) cDNA(49) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006017 (Evidence)
Ensembl Gene ModelENSMUSG00000020884 (Evidence)
Entrez Gene11889 (Evidence)
UniGene6559
DFCITC1583074, TC1686070
DoTSDT.101375056, DT.60198219, DT.94271487
NIA Mouse Gene IndexU043968
Consensus CDS ProjectCCDS24933.1, CCDS70224.1
International Mouse Knockout Project StatusAsgr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006017 VEGA Gene Model | MGI Sequence Detail 3810 C57BL/6J ±  kb
transcript OTTMUST00000013490 VEGA | MGI Sequence Detail 1188 Not Applicable 
polypeptide OTTMUSP00000006250 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(3)
Polymorphisms RFLP(3) : SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR005640 Hepatic lectin, N-terminal
Protein Ontology PR:000004369 asialoglycoprotein receptor 1
References (Earliest) J:9558 Reddy NS, et al., Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells. Gene. 1988 Oct 30;70(2):231-43
(Latest) J:183993 Sabrautzki S, et al., New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis. Mamm Genome. 2012 Aug;23(7-8):416-30
All references(53)
Other
accession IDs
MGD-MRK-1414, MGD-MRK-1415, MGD-MRK-1417

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory