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Arsa
Gene Detail
Symbol

Name
ID
Arsa
arylsulfatase A
MGI:88077
Synonyms
As2, As-2, ASA, AS-A
Feature Type
protein coding gene
Genetic Map
Chromosome 15
44.94 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:89472476-89477425 bp, - strand
From VEGA annotation of GRCm38

  4950 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20138  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: arylsulfatase-like protein
Gene Tree: Arsa

Human
homologs
Human Homolog ARSA, arylsulfatase A
NCBI Gene ID 410
neXtProt AC  NX_P15289
Human Synonyms  MLD
Human Chr (Location)  22q13.33; chr22:50622754-50628173 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ARSA
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Radiation induced(1) Targeted(1)
Genomic Mutations involving Arsa (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice exhibit impaired balance and spatial learning ability. Sulfatide accumulates in the white matter of the brain and a reduced myelin sheath thickness in the corpus callosum and optic nerves is seen. A low frequency of head tremor develops after 2 years of age.
 
Human Diseases Modeled Using Mouse Arsa (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Arsa interacts with 87 markers (Mir23a, Mir23b, Mir29a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process autophagy, binding of sperm to zona pellucida, ...
Component acrosomal vesicle, cytoplasm, ...
Function arylsulfatase activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (127)    Tissues (117)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 120
RT-PCR 7
cDNA source data(73)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(80) Genomic(4) cDNA(74) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000035225 (Evidence)
Ensembl Gene ModelENSMUSG00000022620 (Evidence)
Entrez Gene11883 (Evidence)
UniGene620
DFCITC1575636, TC1774678
DoTSDT.110836741, DT.534316
NIA Mouse Gene IndexU016566
EC3.1.6.8
Consensus CDS ProjectCCDS27753.1
International Mouse Knockout Project StatusArsa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035225 VEGA Gene Model | MGI Sequence Detail 4950 C57BL/6J ±  kb
transcript OTTMUST00000089775 VEGA | MGI Sequence Detail 3492 Not Applicable 
polypeptide OTTMUSP00000049092 VEGA | MGI Sequence Detail 506 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR000917 Sulfatase
InterPro IPR024607 Sulfatase, conserved site
Protein Ontology PR:000004321 arylsulfatase A
References
(Earliest) J:6651 Francke U, et al., Conserved autosomal syntenic group on mouse (MMU) chromosome 15 and human (HSA) chromosome 22: assignment of a gene for arylsulfatase A to MMU 15 and regional mapping of DIA1, ARSA, and ACO2 on HSA 22. Cytogenet Cell Genet. 1981;31(2):58-69
(Latest) J:191694 Xu H, et al., Sperm arylsulfatase A binds to mZP2 and mZP3 glycoproteins in a nonenzymatic manner. Reproduction. 2012 Aug;144(2):209-19
All references(68)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1396, MGD-MRK-1402, MGD-MRK-1407, MGI:2146209

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory