About   Help   FAQ
Arsa
Gene Detail
Symbol

Name
ID
Arsa
arylsulfatase A
MGI:88077
Synonyms
As2, As-2, ASA, AS-A
Feature Type
protein coding gene
Genetic Map
Chromosome 15
44.94 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:89472476-89477425 bp, - strand
From VEGA annotation of GRCm38

  4950 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20138  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: ARSA
Protein SuperFamily: arylsulfatase-like protein
Gene Tree: Arsa

Human
homologs
ARSA, arylsulfatase A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 410
neXtProt AC: NX_P15289

Human Synonyms: MLD

Human Chr (Location): 22q13.33; chr22:50622754-50628173 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ARSA

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Radiation induced(1) Targeted(1)
Genomic Mutations involving Arsa (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice exhibit impaired balance and spatial learning ability. Sulfatide accumulates in the white matter of the brain and a reduced myelin sheath thickness in the corpus callosum and optic nerves is seen. A low frequency of head tremor develops after 2 years of age.
 
Human Diseases Modeled in Mice Using Arsa (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Arsa interacts with 86 markers (Mir23a, Mir23b, Mir29a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process autophagy, binding of sperm to zona pellucida, ...
Component acrosomal vesicle, cytoplasm, ...
Function arylsulfatase activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (127)    Tissues (117)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 120
RT-PCR 7
cDNA source data(73)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase arsa, LOC100486429 ; ZFIN arsa    NEW 
Molecular
reagents
All nucleic(80) Genomic(4) cDNA(74) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000035225 (Evidence)
Ensembl Gene Model ENSMUSG00000022620 (Evidence)
Entrez Gene 11883 (Evidence)
UniGene 620
DFCI TC1575636, TC1774678
DoTS DT.110836741, DT.534316
NIA Mouse Gene Index U016566
EC 3.1.6.8
Consensus CDS Project CCDS27753.1
International Mouse Phenotyping Consortium Status Arsa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035225 VEGA Gene Model | MGI Sequence Detail 4950 C57BL/6J ±  kb
transcript OTTMUST00000089775 VEGA | MGI Sequence Detail 3492 Not Applicable 
polypeptide OTTMUSP00000049092 VEGA | MGI Sequence Detail 506 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR000917 Sulfatase
InterPro IPR024607 Sulfatase, conserved site
Protein Ontology PR:000004321 arylsulfatase A
References
(Earliest) J:6651 Francke U, et al., Conserved autosomal syntenic group on mouse (MMU) chromosome 15 and human (HSA) chromosome 22: assignment of a gene for arylsulfatase A to MMU 15 and regional mapping of DIA1, ARSA, and ACO2 on HSA 22. Cytogenet Cell Genet. 1981;31(2):58-69
(Latest) J:221166 Mirzaian M, et al., Quantification of sulfatides and lysosulfatides in tissues and body fluids by liquid chromatography-tandem mass spectrometry. J Lipid Res. 2015 Apr;56(4):936-43
All references(69)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1396, MGD-MRK-1402, MGD-MRK-1407, MGI:2146209

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory