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Arsb Gene Detail
Summary
  • Symbol
    Arsb
  • Name
    arylsulfatase B
  • Synonyms
    1110007C02Rik, As1, As-1, As-1r, As1-r, As-1s, As1-s, As-1t, As1-t, Asr-1, Ast-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88075
    NCBI Gene: 11881
Location & Maps
more
  • Sequence Map
    Chr13:93771679-93943016 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      171338 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 47.88 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    28 experiments
Homology
more
  • Human Ortholog
    ARSB, arylsulfatase B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARSB, arylsulfatase B
    Orthology source: HomoloGene
  • Synonyms
    ASB, G4S, MPS6
  • Links
    NCBI Gene ID: 411
    neXtProt AC: NX_P15848

  • Chr Location
    5q14.1; chr5:78777209-78986534 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Arsb mouse models; 1 with human ARSB associations

Human Disease Mouse Models
       Mucopolysaccharidosis Type VI; MPS6   OMIM: 253200 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 2 alleles in 3 genetic backgrounds
    7 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Arsb
  • Incidental Mutations
Homozygous mutation of this gene results in development of shortened limbs and snout and a broadened head after 4 weeks of age. Mutant animals have elevated concentrations of glucosaminoglycans in the urine and irregular cartilage structure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042082 Ensembl Gene Model | MGI Sequence Detail 171338 C57BL/6J ±  kb
transcript ENSMUST00000091403 Ensembl | MGI Sequence Detail 3989 Not Applicable  
polypeptide ENSMUSP00000088964 Ensembl | MGI Sequence Detail 534 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1478 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 20
    Genomic 2
    cDNA 16
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-1398, MGD-MRK-1399, MGD-MRK-1400, MGD-MRK-1401, MGD-MRK-1403, MGD-MRK-1404, MGD-MRK-1405, MGD-MRK-1406, MGD-MRK-1429, MGD-MRK-1434, MGI:1919034, MGI:2145257, MGI:88073, MGI:88074, MGI:88076
References
more
  • Summaries
    All 52
    Developmental Gene Expression 3
    Diseases 3
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:5769 Daniel WL, Genetic control of heat sensitivity and activity level of murine arylsulfatase B. Biochem Genet. 1976 Dec;14(11-12):1003-18
  • Latest
    J:223062 Palmer K, et al., Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. Dev Biol. 2015 Jul 30;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory