Arsb
Gene Detail

Symbol Name ID

Arsb arylsulfatase B MGI:88075

Synonyms

1110007C02Rik, As1, As-1, As-1r, As1-r, As-1s, As1-s, As-1t, As1-t, Asr-1, Ast-1

Feature Type

protein coding gene

Genetic Map

Chromosome 13

47.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)

Sequence Map

Chr13:93771679-93943016 bp, + strand From NCBI annotation of GRCm38   171338 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:73870  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: arylsulfatase-like protein
Gene Tree: Arsb

Human homologs

Human Homolog		ARSB, arylsulfatase B
NCBI Gene ID		411
neXtProt AC		NX_P15848
Human Synonyms		ASB, G4S, MPS6
Human Chr (Location)		5q14.1; chr5:78073032-78282357 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ARSB

Alleles and phenotypes

All alleles(2) : Targeted(1) Chemically induced(1)
 

Homozygous mutation of this gene results in development of shortened limbs and snout and a broadened head after 4 weeks of age. Mutant animals have elevated concentrations of glucosaminoglycans in the urine and irregular cartilage structure.

 
Human Diseases Modeled Using Mouse Arsb (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	autophagy, central nervous system development, ...
Component	Golgi apparatus, lysosome, ...
Function	arylsulfatase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (144)    Tissues (103)    Images (27)
Theiler Stages: 20, 22, 23, 24

Assay Type	Results
RNA in situ	144

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(2) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000042082 (Evidence)
Entrez Gene	11881 (Evidence)
DFCI	TC1582264, TC1584055, TC1592884, TC1599138
DoTS	DT.101166835, DT.101366071, DT.91327783
NIA Mouse Gene Index	U015123
EC	3.1.6.12
Consensus CDS Project	CCDS36749.1
International Mouse Knockout Project Status	Arsb

Sequences

Length	Strain/Species
genomic	11881	NCBI Gene Model | MGI Sequence Detail	171338	C57BL/6J
transcript	NM_009712	RefSeq | MGI Sequence Detail	3989	C57BL/6
polypeptide	P50429	UniProt | EBI | MGI Sequence Detail	534	Not Applicable

All sequences(43) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(3) : SNPs(1057 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017849	Alkaline phosphatase-like, alpha/beta/alpha
InterPro	IPR017850	Alkaline-phosphatase-like, core domain
InterPro	IPR000917	Sulfatase
InterPro	IPR024607	Sulfatase, conserved site
Protein Ontology	PR:000004322	arylsulfatase B

Graphical View of Protein Domain Structure

References

(Earliest) J:5769 Daniel WL, Genetic control of heat sensitivity and activity level of murine arylsulfatase B. Biochem Genet. 1976 Dec;14(11-12):1003-18
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(56)

Other accession IDs

MGD-MRK-1398, MGD-MRK-1399, MGD-MRK-1400, MGD-MRK-1401, MGD-MRK-1403, MGD-MRK-1404, MGD-MRK-1405, MGD-MRK-1406, MGD-MRK-1429, MGD-MRK-1434, MGI:1919034, MGI:2145257, MGI:88073, MGI:88074, MGI:88076