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Arsb
Gene Detail
Symbol

Name
ID
Arsb
arylsulfatase B
MGI:88075
Synonyms
1110007C02Rik, As1, As-1, As-1r, As1-r, As-1s, As1-s, As-1t, As1-t, Asr-1, Ast-1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
47.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr13:93771679-93943016 bp, + strand
From NCBI annotation of GRCm38

  171338 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:73870  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: arylsulfatase-like protein
Gene Tree: Arsb

Human
homologs
Human Homolog ARSB, arylsulfatase B
NCBI Gene ID 411
neXtProt AC  NX_P15848
Human Synonyms  ASB, G4S, MPS6
Human Chr (Location)  5q14.1; chr5:78777209-78986534 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ARSB
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Chemically induced (ENU)(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in development of shortened limbs and snout and a broadened head after 4 weeks of age. Mutant animals have elevated concentrations of glucosaminoglycans in the urine and irregular cartilage structure.
 
Human Diseases Modeled Using Mouse Arsb (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(5)
Interactions
Arsb interacts with 252 markers (Mir7-1, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process autophagy, central nervous system development, ...
Component extracellular vesicular exosome, Golgi apparatus, ...
Function arylsulfatase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (144)    Tissues (103)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 144
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(2) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000042082 (Evidence)
Entrez Gene11881 (Evidence)
DFCITC1582264, TC1584055, TC1592884, TC1599138
DoTSDT.101166835, DT.101366071, DT.91327783
NIA Mouse Gene IndexU015123
EC3.1.6.12
Consensus CDS ProjectCCDS36749.1
International Mouse Knockout Project StatusArsb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11881 NCBI Gene Model | MGI Sequence Detail 171338 C57BL/6J ±  kb
transcript NM_009712 RefSeq | MGI Sequence Detail 3989 C57BL/6 
polypeptide P50429 UniProt | EBI | MGI Sequence Detail 534 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(1496 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1498)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR000917 Sulfatase
InterPro IPR024607 Sulfatase, conserved site
Protein Ontology PR:000004322 arylsulfatase B
Graphical View of Protein Domain Structure
References
(Earliest) J:5769 Daniel WL, Genetic control of heat sensitivity and activity level of murine arylsulfatase B. Biochem Genet. 1976 Dec;14(11-12):1003-18
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(57)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-1398, MGD-MRK-1399, MGD-MRK-1400, MGD-MRK-1401, MGD-MRK-1403, MGD-MRK-1404, MGD-MRK-1405, MGD-MRK-1406, MGD-MRK-1429, MGD-MRK-1434, MGI:1919034, MGI:2145257, MGI:88073, MGI:88074, MGI:88076

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory