About   Help   FAQ
Arnt
Gene Detail
Symbol

Name
ID
Arnt
aryl hydrocarbon receptor nuclear translocator
MGI:88071
Synonyms
bHLHe2, D3Ertd557e, ESTM42, Hif1b
Feature Type
protein coding gene
Genetic Map
Chromosome 3
40.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr3:95434388-95497237 bp, + strand
From VEGA annotation of GRCm38

  62850 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1261  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: aryl hydrocarbon receptor nuclear translocator
Gene Tree: Arnt

Human
homologs
Human Homolog ARNT, aryl hydrocarbon receptor nuclear translocator
NCBI Gene ID 405
neXtProt AC  NX_P27540
Human Synonyms  bHLHe2, HIF1B, HIF-1beta, HIF-1-beta, HIF1-beta, HIF1BETA, TANGO
Human Chr (Location)  1q21; chr1:150809705-150876768 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(30) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit loss of aryl hydrocarbon receptor and hypoxia-inducible factor 1 alpha gene induction, defective angiogenesis of the yolk sac and branchial arches, placental defects, and lethality by embryonic day 10.5.
 
Interactions
Arnt interacts with 308 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process cell differentiation, embryonic placenta development, ...
Component cytoplasm, nucleus, ...
Function aryl hydrocarbon receptor activity, aryl hydrocarbon receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (438)    Tissues (296)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 32
RNA in situ 345
Northern blot 30
Western blot 9
RT-PCR 22
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) Genomic(9) cDNA(31) Primer pair(7) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000016472 (Evidence)
Ensembl Gene ModelENSMUSG00000015522 (Evidence)
Entrez Gene11863 (Evidence)
DFCITC1578057, TC1584160, TC1629502
DoTSDT.101234753, DT.101358789, DT.101706191, DT.101737879, DT.110469459, DT.110469474, DT.91339091, DT.91363125, DT.94147490
NIA Mouse Gene IndexU003569
Consensus CDS ProjectCCDS17614.1, CCDS38546.1
International Mouse Knockout Project StatusArnt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016472 VEGA Gene Model | MGI Sequence Detail 62850 C57BL/6J ±  kb
transcript OTTMUST00000039717 VEGA | MGI Sequence Detail 2699 Not Applicable 
polypeptide OTTMUSP00000017720 VEGA | MGI Sequence Detail 791 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(12) UniProt(17)
Polymorphisms
RFLP(1) : SNPs within 2kb(695 from dbSNP Build 137)    SNPs within 2kb including multiple locations(699)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR001067 Nuclear translocator
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
Protein Ontology PR:000004303 aryl hydrocarbon receptor nuclear translocator
References
(Earliest) J:12121 Brooks B, et al., Localization of a gene required for the nuclear translocation of the dioxin receptor to human chromosome 1 and mouse chromosome 3 and a human RFLP with MspI. Am J Hum Genet. 1989;45:A132 (Abstr.)
(Latest) J:213532 Ramakrishnan SK, et al., Loss of von Hippel-Lindau protein (VHL) increases systemic cholesterol levels through targeting hypoxia-inducible factor 2alpha and regulation of bile acid homeostasis. Mol Cell Biol. 2014 Apr;34(7):1208-20
All references(169)
Other
accession IDs
MGD-MRK-1394, MGD-MRK-8902, MGI:1261868, MGI:1334432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory