Arc
Gene Detail

Symbol Name ID

Arc activity regulated cytoskeletal-associated protein MGI:88067

Synonyms

Arc3.1, arg 3.1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

34.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:74669083-74672570 bp, - strand From VEGA annotation of GRCm38   3488 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9056  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken

Gene Tree: Arc

Human homologs

Human Homolog		ARC, activity-regulated cytoskeleton-associated protein
NCBI Gene ID		23237
neXtProt AC		NX_Q7LC44
Human Synonyms		Arg3.1
Human Chr (Location)		8q24.3; chr8:143692405-143695833 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous deletion of this gene results in embryonic lethality around E6.5.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	anterior/posterior pattern specification, cell migration, ...
Component	actin cytoskeleton, cell junction, ...
Function	actin binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (42)    Tissues (34)    Images (15)
Theiler Stages: 9, 11, 13, 19, 22, 23, 28

Assay Type	Results
RNA in situ	42

cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(6) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016386 (Evidence)
Ensembl Gene Model	ENSMUSG00000022602 (Evidence)
Entrez Gene	11838 (Evidence)
DFCI	TC1581396
DoTS	DT.40177849
NIA Mouse Gene Index	U036283
Consensus CDS Project	CCDS37102.1
International Mouse Knockout Project Status	Arc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016386	VEGA Gene Model | MGI Sequence Detail	3488	C57BL/6J
transcript	OTTMUST00000047955	VEGA | MGI Sequence Detail	3039	Not Applicable
polypeptide	OTTMUSP00000021864	VEGA | MGI Sequence Detail	396	Not Applicable

All sequences(27) RefSeq(4) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(30 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023263	Activity-regulated cytoskeleton-associated protein
Protein Ontology	PR:000004196	activity-regulated cytoskeleton-associated protein

References

(Earliest) J:38767 Letts VA, et al., Genetic and physical maps of the stargazer locus on mouse chromosome 15. Genomics. 1997 Jul 1;43(1):62-8
(Latest) J:186178 Okuno H, et al., Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIbeta. Cell. 2012 May 11;149(4):886-98
All references(45)

Other accession IDs

MGD-MRK-1387, MGI:2146313