About   Help   FAQ
Arc
Gene Detail
Symbol

Name
ID
Arc
activity regulated cytoskeletal-associated protein
MGI:88067
Synonyms
Arc3.1, arg 3.1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
34.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:74669083-74672570 bp, - strand
From VEGA annotation of GRCm38

  3488 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9056  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog

HCOP human homology predictions: ARC
Gene Tree: Arc

Human
homologs
ARC, activity-regulated cytoskeleton-associated protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23237
neXtProt AC: NX_Q7LC44

Human Synonyms: Arg3.1

Human Chr (Location): 8q24.3; chr8:142611044-142614472 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Arc (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous deletion of this gene results in embryonic lethality around E6.5.
 
Phenotype Images(2)
Interactions
Arc interacts with 228 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process anterior/posterior pattern specification, cell migration, ...
Component actin cytoskeleton, cell junction, ...
Function actin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (90)    Tissues (82)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 90
cDNA source data(6)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase arc    NEW 
Molecular
reagents
All nucleic(8) cDNA(6) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016386 (Evidence)
Ensembl Gene Model ENSMUSG00000022602 (Evidence)
Entrez Gene 11838 (Evidence)
DFCI TC1581396
DoTS DT.40177849
NIA Mouse Gene Index U036283
Consensus CDS Project CCDS37102.1
International Mouse Phenotyping Consortium Status Arc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016386 VEGA Gene Model | MGI Sequence Detail 3488 C57BL/6J ±  kb
transcript OTTMUST00000047955 VEGA | MGI Sequence Detail 3055 Not Applicable 
polypeptide OTTMUSP00000021864 VEGA | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023263 Activity-regulated cytoskeleton-associated protein
Protein Ontology PR:000004196 activity-regulated cytoskeleton-associated protein
References
(Earliest) J:38767 Letts VA, et al., Genetic and physical maps of the stargazer locus on mouse chromosome 15. Genomics. 1997 Jul 1;43(1):62-8
(Latest) J:215456 Denny CA, et al., Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. Neuron. 2014 Jul 2;83(1):189-201
All references(52)
Other
accession IDs
MGD-MRK-1387, MGI:2146313

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory