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Arc
Gene Detail
 Symbol
Name
ID
Arc
activity regulated cytoskeletal-associated protein
MGI:88067
Synonyms Arc3.1, arg 3.1
Feature Type protein coding gene
Genetic Map
Chromosome 15
34.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:74669083-74672570 bp, - strand
From VEGA annotation of GRCm38

  3488 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9056  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken

Gene Tree: Arc

Human
homologs
Human Homolog ARC, activity-regulated cytoskeleton-associated protein
NCBI Gene ID 23237
neXtProt AC  NX_Q7LC44
Human Synonyms  Arg3.1
Human Chr (Location)  8q24.3; chr8:142611044-142614472 (-)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous deletion of this gene results in embryonic lethality around E6.5.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process anterior/posterior pattern specification, cell migration, ...
Component actin cytoskeleton, cell junction, ...
Function actin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (90)    Tissues (82)    Images (17)
Theiler Stages: 9, 11, 13, 19, 22, 23, 26, 28
Assay TypeResults
RNA in situ 90
cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(8) cDNA(6) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016386 (Evidence)
Ensembl Gene ModelENSMUSG00000022602 (Evidence)
Entrez Gene11838 (Evidence)
DFCITC1581396
DoTSDT.40177849
NIA Mouse Gene IndexU036283
Consensus CDS ProjectCCDS37102.1
International Mouse Knockout Project StatusArc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016386 VEGA Gene Model | MGI Sequence Detail 3488 C57BL/6J ±  kb
transcript OTTMUST00000047955 VEGA | MGI Sequence Detail 3055 Not Applicable 
polypeptide OTTMUSP00000021864 VEGA | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023263 Activity-regulated cytoskeleton-associated protein
Protein Ontology PR:000004196 activity-regulated cytoskeleton-associated protein
References (Earliest) J:38767 Letts VA, et al., Genetic and physical maps of the stargazer locus on mouse chromosome 15. Genomics. 1997 Jul 1;43(1):62-8
(Latest) J:203747 Korb E, et al., Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity. Nat Neurosci. 2013 Jul;16(7):874-83
All references(50)
Other
accession IDs
MGD-MRK-1387, MGI:2146313

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory